Pharmacokinetics and Pharmacodynamics of Abused Drugs, Karch, MD FFFLM Steven B.
Автор: Rosenbaum Sara E. Название: Basic Pharmacokinetics and Pharmacodynamics ISBN: 1119143152 ISBN-13(EAN): 9781119143154 Издательство: Wiley Рейтинг: Цена: 72810.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book provides a comprehensive foundation for the contemporary application of pharmacokinetics and pharmacodynamics. The second edition updates and strengthens existing chapters and adds new topics to address current needs including physiologically based pharmacokinetic modeling, pharmacogenomics and predicting drug-drug interactions.
Автор: Alexander A. Vinks; Hartmut Derendorf; Johan W. Mo Название: Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics ISBN: 1493950819 ISBN-13(EAN): 9781493950812 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. The book will be designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader will be introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, and the translation of in vitro and animal model data to basic research and clinical situations in humans.
Автор: Michelle A. Rudek; Cindy H. Chau; William D. Figg; Название: Handbook of Anticancer Pharmacokinetics and Pharmacodynamics ISBN: 1493938983 ISBN-13(EAN): 9781493938988 Издательство: Springer Рейтинг: Цена: 232910.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. * Road map to anticancer drug development from discovery to NDA submission * Discussion of molecular targets and preclinical screening * Development and validation of bioanalytical methods * Chapters on clinical trial design and phase 0, I, II, III clinical trials * Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents * Review of the drug development process from both laboratory and clinical perspectives * New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development
Автор: Macheras Panos, Iliadis Athanassios Название: Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics / Homogeneous and Heterogeneous Approaches ISBN: 0387281789 ISBN-13(EAN): 9780387281780 Издательство: Springer Рейтинг: Цена: 55850.00 T Наличие на складе: Поставка под заказ. Описание: The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with empirical, compartmental, and stochastic pharmacokinetic models, and the fourth mainly with nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods. The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with empirical, compartmental, and stochastic pharmacokinetic models, and the fourth mainly with nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods. www.springeronline.com
Автор: A. Yacobi; J.P. Skelly; Vinod P. Shah; L.Z. Benet Название: Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development ISBN: 1475715226 ISBN-13(EAN): 9781475715224 Издательство: Springer Рейтинг: Цена: 104480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of a conference sponsored by the American Association of Pharmaceutical Scientists, the U.S. Food and Drug Administration, and the American Society for Clinical Pharmacology and Therapeutics, held in Arlington, Virginia, April 24-26, 1991
Автор: Younggil Kwon Название: Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists ISBN: 147578693X ISBN-13(EAN): 9781475786934 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization.
Автор: Hedaya, Mohsen A. , Puri, Basant K. Название: Making Sense of Pharmacokinetics and Pharmacodynamics ISBN: 0367140918 ISBN-13(EAN): 9780367140915 Издательство: Taylor&Francis Рейтинг: Цена: 22450.00 T Наличие на складе: Нет в наличии. Описание: Making Sense of Pharmacokinetics and Pharmacodynamics has been written as a practical and accessible guide to help the student and more experienced practitioner navigate these complex areas in order to understand better how drugs work and how, in turn, this knowledge underpins appropriate prescribing decisions.
Автор: Macheras Panos, Iliadis Athanassios Название: Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics: Homogeneous and Heterogeneous Approaches ISBN: 3319801813 ISBN-13(EAN): 9783319801810 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this new second edition book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with epirical, compartmental, and stochastic pharmacokinetic models, with two new chapters, one on fractional pharmacokinetics and one on bioequivalence; and the fourth mainly with classical and nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. This second edition has new information on reaction limited models of dissolution, non binary biopharmaceutic classification system, time varying models, and interface models. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods. This book will appeal to graduate students and researchers in pharmacology, pharmaceutical sciences, bioengineering, and physiology. Reviews of the first edition: "This book presents a novel modelling approach to biopharmaceutics, pharmacokinetics and pharmacodynamic phenomena. This state-of-the-art volume will be helpful to students and researchers in pharmacology, bioengineering, and physiology. This book is a must for pharmaceutical researchers to keep up with recent developments in this field." (P. R. Parthasarathy, Zentralblatt MATH, Vol. 1103 (5), 2007) "These authors are the unique (or sole) contributors in this area that are working on these questions and bring a special expertise to the field that is now being recognized as essential to understanding biological system and kinetic/dynamic characteristics in drug development...This text is an essential primer for those who would envision the incorporation of heterogeneous approaches to systems where homogeneous approaches are not sufficient to describe the system." (Robert R. Bies, Journal of Clinical Pharmacology, Vol. 46, 2006)
Автор: Patel Jayvadan, Pathak Yashwant V. Название: Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems ISBN: 3030833941 ISBN-13(EAN): 9783030833947 Издательство: Springer Рейтинг: Цена: 260870.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: A reference is needed that addresses the recent progress in aspects of PK/PD methods and developments of nanoparticles for novel drug delivery systems. No other consolidated published reference discusses the PK/PD study of nanoparticle drug delivery systems. This book discusses the advantages of nanoparticle drug delivery systems (NPDDS) in enhancing the pharmacokinetics of many drugs that are not easily metabolized or that obtain the desired therapeutic effect with minimum toxicity. The authors provide an overview of biodistribution with a focus on polymer and lipid nanoparticles. This thorough reference is divided into three parts: Modelling, Specific carries and their potential to treat specific diseases.
Автор: Derendorf Название: Rowland and Tozer`s Clinical Pharmacokinetics and Pharmacodynamics: ISBN: 1496385047 ISBN-13(EAN): 9781496385048 Издательство: Lippincott Williams & Wilkins Рейтинг: Цена: 97240.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Updated with the latest clinical advances, Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition, explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.
Key updates reflect advances in PK/PD as related to clinical decision making and drug research and development.
An emphasis on the clinical relevance of drugs makes the book especially applicable to pharmacy students preparing for a career in clinical practice.
Hundreds of graphs and tables provide visual representations of key pharmacokinetic/pharmacodynamic principles and effects.
More than 200 carefully written study questions, with answers and in-depth explanations, help readers enhance their conceptual understanding and learn and retain key information.
New and updated examples connect chapter content to real-world settings.
Interactive online simulations give students practice using different pharmacokinetic/pharmacodynamic models and parameters.
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Автор: Panos Macheras; Athanassios Iliadis Название: Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics ISBN: 3319275968 ISBN-13(EAN): 9783319275963 Издательство: Springer Рейтинг: Цена: 111790.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this new second edition book. This second edition has new information on reaction limited models of dissolution, non binary biopharmaceutic classification system, time varying models, and interface models.
