Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, Michelle A. Rudek; Cindy H. Chau; William D. Figg;

Автор: Michelle A. Rudek; Cindy H. Chau; William D. Figg;
Название: Handbook of Anticancer Pharmacokinetics and Pharmacodynamics
ISBN: 1461491347 ISBN-13(EAN): 9781461491347
Издательство: Springer
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Цена: 243800.00 T
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Описание: This book offers a detailed, step-by-step guide to the successful design and approval of anticancer drugs. It covers all steps, from the identification of cancer-specific molecular targets to clinical trial design and all the phases of clinical trials.

Автор: Rowland
Название: Clinical Pharmacokinetics and Pharmacodynamics, 4e
ISBN: 0781750091 ISBN-13(EAN): 9780781750097
Издательство: Lippincott Williams & Wilkins
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Цена: 80080.00 T
Наличие на складе: Невозможна поставка.
Описание: Reflects the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This title also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs.

Автор: Younggil Kwon
Название: Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists
ISBN: 147578693X ISBN-13(EAN): 9781475786934
Издательство: Springer
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Цена: 149060.00 T
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Описание: In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization.

Автор: A. Yacobi; J.P. Skelly; Vinod P. Shah; L.Z. Benet
Название: Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development
ISBN: 1475715226 ISBN-13(EAN): 9781475715224
Издательство: Springer
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Цена: 104480.00 T
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Описание: Proceedings of a conference sponsored by the American Association of Pharmaceutical Scientists, the U.S. Food and Drug Administration, and the American Society for Clinical Pharmacology and Therapeutics, held in Arlington, Virginia, April 24-26, 1991

Автор: Bobbe L. Ferraiolo; Marjorie A. Mohler; Carol A. G
Название: Protein Pharmacokinetics and Metabolism
ISBN: 1489923314 ISBN-13(EAN): 9781489923318
Издательство: Springer
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Цена: 174150.00 T
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Описание: Investigation of the pharmacokinetics and metabolism of human proteins has escalated over the last two decades because of the use of recombinant human proteins as therapeutic agents.

Автор: Rescigno Aldo
Название: Foundations of Pharmacokinetics
ISBN: 0306477041 ISBN-13(EAN): 9780306477041
Издательство: Springer
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Цена: 174150.00 T
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Описание: This book is divided into two parts; in the first part the principles and the methods of pharmacokinetics are described in detail, while in the second the main pharmacokinetic parameters are described, giving for each of them the definition, the principal properties, and the methods of determination. An appendix contains the important mathematical instruments used in the main part of the book, namely the operational calculus and the convolution integral. In the second part there is a careful distinction among pharmacokinetic parameters, i.e., parameters that represent a true pharmacokinetic property, model parameters, i.e., parameters that represent a property of a specific model, and incidental parameters, i.e., parameters that represent only the result of a particular experiment. Special care is taken to distinguish between the definition of a parameter, and the properties that derive from that definition; a considerable emphasis is also given to the fact that each method for the determination of a parameter is dependent on the specific model it is based on.

Автор: John K. Buolamwini; Alex A. Adjei
Название: Novel Anticancer Drug Protocols
ISBN: 1489938397 ISBN-13(EAN): 9781489938398
Издательство: Springer
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Цена: 111790.00 T
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Описание: We are in an exciting era in the war against cancer, with real prospects for novel anticancer drugs that are cancer cell-specific without the toxicities that have been the hallmark of conventional cytotoxic cancer chemotherapy.

Автор: Bauer
Название: Applied Clinical Pharmacokinetics
ISBN: 0071794581 ISBN-13(EAN): 9780071794589
Издательство: McGraw-Hill
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Цена: 84650.00 T
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Описание: Helps you learn the clinical application of pharmacokinetics. This book delivers clear and clinically relevant coverage of drug dosing and drug monitoring that no other text can match. It offers the standardized techniques and approaches to patient-specific dosing, and information on pharmacokinetically monitored drugs.

Автор: Winter
Название: Basic Clinical Pharmacokinetics
ISBN: 0781741475 ISBN-13(EAN): 9780781741477
Издательство: Lippincott Williams & Wilkins
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Цена: 41750.00 T
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Описание: Basic Clinical Pharmacokinetics was designed to simplify pharmacokinetics to help busy practitioners understand and visualize basic principles. An easy-to-read, case-study format has made the text a favorite among clinical professors, students, and practitioners. The text provides an introduction to the principles of monitoring drug therapy for those involved in the interpretation of drug levels in a patient care setting. Part One provides a basic review of pharmacokinetic principles. Extensive explanations, graphic illustrations, and detailed algorithms teach the principles of bioavailability, volume of distribution, clearance, elimination rate constant, and half-life. Part Two explains the clinical applications of these principles. Solutions to problems commonly encountered in the practice setting are discussed for specific drugs. Appendices provide commonly used equations and a glossary of pharmacokinetic terms and abbreviations. New to this edition are chapters on tricyclic antidepressants and cyclosporine, an expanded chapter on dialysis, and updated information on choosing equations and interpreting plasma drug concentrations.

Автор: Aldo Rescigno
Название: Foundations of Pharmacokinetics
ISBN: 1475787391 ISBN-13(EAN): 9781475787399
Издательство: Springer
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Цена: 149060.00 T
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Описание: This book has its origin in my experience as a teacher of pharmacokinetics in many universities in four different continents. Chapters 13 to 17 show how different parameters of importance in pharmacokinetics can be exactly defined and measured.

Автор: Peter L. Bonate; Danny R. Howard
Название: Pharmacokinetics in Drug Development
ISBN: 1489977996 ISBN-13(EAN): 9781489977991
Издательство: Springer
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Цена: 186330.00 T
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Описание: The topics chosen for this volume were selected because they are some of the current development or technological issues facing drug development project teams. They regard the practical considerations for assessment of selected special development populations. For example, they include characterization of drug disposition in pregnant subjects, for measuring arrhythmic potential, for analysis tumor growth modeling, and for disease progression modeling. Practical considerations for metabolite safety testing, transporter assessments, Phase 0 testing, and development and execution of drug interaction programs reflect current regulatory topics meant to address enhancement of both safety assessment and early decision-making during new candidate selection. Important technologies like whole body autoradiography, digital imaging and dried blood spot sample collection methods are introduced, as both have begun to take a more visible role in pharmacokinetic departments throughout the industry.