Neurobiology of Huntington`s Disease, Lo, Donald C.
Автор: Hoa Huu Phuc Nguyen; M. Angela Cenci Название: Behavioral Neurobiology of Huntington`s Disease and Parkinson`s Disease ISBN: 3662463431 ISBN-13(EAN): 9783662463437 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Motor dysfunction and cognitive impairment are major symptoms in both Huntington’s Disease (HD) and Parkinson’s Disease (PD). A breakthrough in HD research was the identification of the gene that causes this devastating monogenetic illness. Similarly, several genes were found to cause familial forms of PD. With their identification, a plethora of genetic animal models has been generated and has revolutionized the understanding of the pathobiology and pathophysiology of these disorders. The models allow us to study the earliest manifestations of the diseases behaviorally and neuropathologically and help us understand how they progress over time. Additionally, neurotoxic animal models are still of high interest to the PD field, as they are being used to study e.g. mitochondrial dysfunction in PD. This book focuses on animal models of both diseases and how they have helped and will continue to help understand the behavioral neurobiology in these disorders.
Автор: Quarrell, Oliver W J (consultant In Clinical Genetics, Sheffield Children`s Hospital, Sheffield, Uk) Название: Huntington`s disease ISBN: 0199212015 ISBN-13(EAN): 9780199212019 Издательство: Oxford Academ Рейтинг: Цена: 15830.00 T Наличие на складе: Поставка под заказ. Описание: Huntington`s disease affects 1 person in 10,000 but this figure is an underestimate because the immediate carer, spouse/partner and the close relatives at risk of developing this condition in the future are also affected. The new edition has been revised to include important new developments that have occurred in the field in recent years.
Автор: Quarrell, Oliver (consultant In Clinical Genetics, Sheffield Children`s Hospital, Sheffield, Uk) Название: Huntington`s disease ISBN: 0198844387 ISBN-13(EAN): 9780198844389 Издательство: Oxford Academ Рейтинг: Цена: 19000.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Huntington`s disease (HD) is a genetically inherited condition resulting in severe nerve-cell damage in the brain. Written for patients and their families, this book explains the features of HD, the role of genetics, and advice on managing symptoms.
Автор: Thomas Название: Biomarkers for Huntington`s Disease ISBN: 3031328140 ISBN-13(EAN): 9783031328145 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Huntington’s disease (HD) is a fatal, inherited, neurodegenerative disorder, characterized by chorea, motor instabilities, psychiatric manifestations and cognitive decline. Early genetic testing provides an opportunity for clinical interventions aimed at delaying onset and/or slowing progression of disease; however, current treatments for HD are limited, with only two FDA-approved drugs available to manage chorea. Encouragingly, however, several disease-modifying treatment approaches are in the therapeutic pipeline, with more than 200 clinical studies, and many more preclinical studies, in the works. Robust and reliable biomarkers are needed to predict disease onset, monitor disease progression and assess treatment responses. More specifically, biomarkers to stratify patients for clinical trials and biomarkers to track drug efficacy will certainly lead to improved clinical trial design and success. This book represents the first book focused solely on biomarkers for HD and represents a distinct resource that will be informative, not only for clinicians and those involved in clinical trial design, but also for a wide range of neurodegenerative disease researchers. This edited volume is written by top leaders in the field, and takes a cross-disciplinary approach to cover a broad spectrum of biomarker types, in order to provide the latest advances in the development of biochemical, molecular, imaging and digital biomarkers that have been investigated for HD. With the ultimate goal of treating patients, the development of disease-associated biomarkers has never been more important.
Автор: Watt Название: A Clinico-Genetic Study of Psychiatric Disorder in Huntington`s Chorea ISBN: 0521459834 ISBN-13(EAN): 9780521459839 Издательство: Cambridge Academ Рейтинг: Цена: 40130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This report presents the findings of a study of people affected by Huntington`s chorea and their unaffected relatives, and in particular, of the incidence of functional psychiatric disorder of various types. It also considers the future prospects of the genetics of the condition
Автор: Precious Название: Huntington`s Disease ISBN: 1493978241 ISBN-13(EAN): 9781493978243 Издательство: Springer Рейтинг: Цена: 204040.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This detailed book provides a laboratory manual and guidebook for the selection, implementation, and interpretation of a wide range of techniques in contemporary use in leading laboratories engaged in Huntington’s disease (HD) research worldwide. Only by understanding the pathology and pathogenic process at the fundamental molecular and cellular level can the research community expect to be able to slow or halt the disease process, repair the damage, and develop novel effective therapies to treat the symptoms of this condition, thus this volume collects the practical knowledge of its authors. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and invaluable, Huntington’s Disease aims to help scientists to significantly extend the breadth and quality of research in laboratories dedicated to mastering and controlling this devastating human condition.
Автор: Bird Thomas D. Название: Can You Help Me?: Inside the Turbulent World of Huntington Disease ISBN: 0190684224 ISBN-13(EAN): 9780190684228 Издательство: Oxford Academ Рейтинг: Цена: 23220.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book describes the framework of the next generation of Business Information Services Library, BiSL(R). BiSL Next is a public domain standard for business information management with guiding principles, good practices and practical templates. It offers guidance for digitally engaged business leaders and those who collaborate with them, with the ultimate goal to improve business performance through better use of information and technology.Twelve elements - four drivers, four domains and four perspectives - are the basis of the guidance in BiSL Next. Target audience of this book are business managers, business information managers, business analysts, CIO`s and IT managers, as well as consultants in this field.While describing the twelve elements, the book offers them insight in the best way to manage, execute and profit from business information management in their enterprise. The book is also the official literature for the BiSL(R) Next Foundation exam.
Автор: Sophie V. Precious; Anne E. Rosser; Stephen B. Dun Название: Huntington`s Disease ISBN: 1493992961 ISBN-13(EAN): 9781493992966 Издательство: Springer Рейтинг: Цена: 204040.00 T Наличие на складе: Поставка под заказ. Описание: This detailed book provides a laboratory manual and guidebook for the selection, implementation, and interpretation of a wide range of techniques in contemporary use in leading laboratories engaged in Huntington’s disease (HD) research worldwide. Only by understanding the pathology and pathogenic process at the fundamental molecular and cellular level can the research community expect to be able to slow or halt the disease process, repair the damage, and develop novel effective therapies to treat the symptoms of this condition, thus this volume collects the practical knowledge of its authors. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and invaluable, Huntington’s Disease aims to help scientists to significantly extend the breadth and quality of research in laboratories dedicated to mastering and controlling this devastating human condition.
Автор: G. Bruyn; M.R. Hayden Название: Huntington`s Chorea ISBN: 1447113101 ISBN-13(EAN): 9781447113102 Издательство: Springer Рейтинг: Цена: 81050.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: It is a pleasure to send Dr. Hayden's monograph on its way to as yet unknown but hopefully widespread destinations with all the valedictions a Foreword may contain. Since I met the author in Cape Town in 1978 I have been struck, on numerous occasions, by the fortuitous combination of an inquisitive mind, a creative drive, a sharp awareness of the historical and social setting of phenomena, and a solid discipline which his personality displays behind a good-natured laugh. If a tree is known by its fruits, both Dr Hayden's PhD thesis and the present monograph afford quite an insight into the auctor intellectualis. The amalgamation of the terrible mise ry behind scientifIc facts and the elegantly artistic presentation of this book will leave none of its readers unperturbed. It reminds me of Nietzsche's 'Denn das Sch ne ist nichts als des Schrecklichen Anfang, und wir bewundern es so weil es gelassen verschm ht uns zu zerst ren' (Beauty is but Horror's beginning, and we admire it because it resignedly spurns to destroy us). The book is a denial, a testimony against Juvenal's spurious 'Sternmata quid faciunt ... ' (of what value are pedigrees). For it is the very genetical prolongation of misery over the centuries that brought Huntington's chorea to South Africa, Australia and the USA from the shores of sea-faring seventeenth-century England and Holland.
Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease summarizes recent developments in intervention trials in neurodegenerative diseases, particularly Alzheimer's and Parkinson's, as well as increasing evidence for the overlap between drivers of metabolic and neurodegenerative disease that impact mitochondrial function and bioenergetics, and subsequently cellular function and pathophysiology. Topics covered include Brain Glucose and Ketone Utilization in Brain Ageing and Neurodegenerative Diseases; the Mitochondrial Hypothesis: Dysfunction, Bioenergetic Defects, and the Metabolic Link to Alzheimer's Disease; the Metabolic Impact on Neuroinflammation and Microglial Modulation in Neurodegenerative Diseases, the Impact of Circadian and Diurnal Rhythms on Cellular Metabolic Function and Neurodegenerative Diseases, and much more.
Summarizes the current status of and future research in Alzheimer's and Parkinson's diseases
Reviews the impact of the metabolic hypothesis on underlying mechanisms of neurodegenerative diseases.
Автор: Rudy Castellani, George Perry Название: Molecular Pathology of Alzheimer`s Disease ISBN: 1615046380 ISBN-13(EAN): 9781615046386 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 61910.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Alzheimer’s Disease is characterized pathologically by two principal hallmark lesions: the senile plaque and the neurofibrillary tangle. Since the identification of each over 100 years ago, the major protein components have been elucidated. This has led in turn to the elaboration of metabolic cascades involving amyloid-? production in the case of the senile plaque, and phosphorylated-tau protein in the case of the neurofibrillary tangle. The pathogenesis and histogenesis of each have been the source of extensive investigation and some controversy in recent years, as both cascades have been implicated in the pathogenesis of Alzheimer’s Disease, relied upon in the diagnostic criteria for Alzheimer’s Disease at autopsy, and targeted for therapeutic intervention. With the accumulation of data and expansion of knowledge of the molecular biology of Alzheimer’s Disease, it appears that the enthusiasm for successful intervention has been premature. In this book, we detail the discovery and characterization of the major pathological lesions, their associated molecular biology, their relationship to clinical disease, and potential fundamental errors in understanding that may be leading scientific investigators in unintended directions.
Автор: Sid Gilman Название: Neurobiology of Disease, ISBN: 0120885921 ISBN-13(EAN): 9780120885923 Издательство: Elsevier Science Рейтинг: Цена: 218960.00 T Наличие на складе: Поставка под заказ. Описание: Aimed at basic scientists or clinician scientists teaching a course or conducting research on the basic science underlying the major neurological diseases, this book provides an overview of research on the fundamental disorders of the nervous system, including physiological and molecular aspects of dysfunction.
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