Huntington`s disease, Quarrell, Oliver W J (consultant In Clinical Genetics, Sheffield Children`s Hospital, Sheffield, Uk)
Автор: Hoa Huu Phuc Nguyen; M. Angela Cenci Название: Behavioral Neurobiology of Huntington`s Disease and Parkinson`s Disease ISBN: 3662463431 ISBN-13(EAN): 9783662463437 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Motor dysfunction and cognitive impairment are major symptoms in both Huntington’s Disease (HD) and Parkinson’s Disease (PD). A breakthrough in HD research was the identification of the gene that causes this devastating monogenetic illness. Similarly, several genes were found to cause familial forms of PD. With their identification, a plethora of genetic animal models has been generated and has revolutionized the understanding of the pathobiology and pathophysiology of these disorders. The models allow us to study the earliest manifestations of the diseases behaviorally and neuropathologically and help us understand how they progress over time. Additionally, neurotoxic animal models are still of high interest to the PD field, as they are being used to study e.g. mitochondrial dysfunction in PD. This book focuses on animal models of both diseases and how they have helped and will continue to help understand the behavioral neurobiology in these disorders.
Автор: Sophie V. Precious; Anne E. Rosser; Stephen B. Dun Название: Huntington`s Disease ISBN: 1493992961 ISBN-13(EAN): 9781493992966 Издательство: Springer Рейтинг: Цена: 204040.00 T Наличие на складе: Поставка под заказ. Описание: This detailed book provides a laboratory manual and guidebook for the selection, implementation, and interpretation of a wide range of techniques in contemporary use in leading laboratories engaged in Huntington’s disease (HD) research worldwide. Only by understanding the pathology and pathogenic process at the fundamental molecular and cellular level can the research community expect to be able to slow or halt the disease process, repair the damage, and develop novel effective therapies to treat the symptoms of this condition, thus this volume collects the practical knowledge of its authors. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and invaluable, Huntington’s Disease aims to help scientists to significantly extend the breadth and quality of research in laboratories dedicated to mastering and controlling this devastating human condition.
Автор: Precious Название: Huntington`s Disease ISBN: 1493978241 ISBN-13(EAN): 9781493978243 Издательство: Springer Рейтинг: Цена: 204040.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This detailed book provides a laboratory manual and guidebook for the selection, implementation, and interpretation of a wide range of techniques in contemporary use in leading laboratories engaged in Huntington’s disease (HD) research worldwide. Only by understanding the pathology and pathogenic process at the fundamental molecular and cellular level can the research community expect to be able to slow or halt the disease process, repair the damage, and develop novel effective therapies to treat the symptoms of this condition, thus this volume collects the practical knowledge of its authors. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and invaluable, Huntington’s Disease aims to help scientists to significantly extend the breadth and quality of research in laboratories dedicated to mastering and controlling this devastating human condition.
Автор: G. Bruyn; M.R. Hayden Название: Huntington`s Chorea ISBN: 1447113101 ISBN-13(EAN): 9781447113102 Издательство: Springer Рейтинг: Цена: 81050.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: It is a pleasure to send Dr. Hayden's monograph on its way to as yet unknown but hopefully widespread destinations with all the valedictions a Foreword may contain. Since I met the author in Cape Town in 1978 I have been struck, on numerous occasions, by the fortuitous combination of an inquisitive mind, a creative drive, a sharp awareness of the historical and social setting of phenomena, and a solid discipline which his personality displays behind a good-natured laugh. If a tree is known by its fruits, both Dr Hayden's PhD thesis and the present monograph afford quite an insight into the auctor intellectualis. The amalgamation of the terrible mise ry behind scientifIc facts and the elegantly artistic presentation of this book will leave none of its readers unperturbed. It reminds me of Nietzsche's 'Denn das Sch ne ist nichts als des Schrecklichen Anfang, und wir bewundern es so weil es gelassen verschm ht uns zu zerst ren' (Beauty is but Horror's beginning, and we admire it because it resignedly spurns to destroy us). The book is a denial, a testimony against Juvenal's spurious 'Sternmata quid faciunt ... ' (of what value are pedigrees). For it is the very genetical prolongation of misery over the centuries that brought Huntington's chorea to South Africa, Australia and the USA from the shores of sea-faring seventeenth-century England and Holland.
Автор: Watt Название: A Clinico-Genetic Study of Psychiatric Disorder in Huntington`s Chorea ISBN: 0521459834 ISBN-13(EAN): 9780521459839 Издательство: Cambridge Academ Рейтинг: Цена: 40130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This report presents the findings of a study of people affected by Huntington`s chorea and their unaffected relatives, and in particular, of the incidence of functional psychiatric disorder of various types. It also considers the future prospects of the genetics of the condition
Автор: Bird Thomas D. Название: Can You Help Me?: Inside the Turbulent World of Huntington Disease ISBN: 0190684224 ISBN-13(EAN): 9780190684228 Издательство: Oxford Academ Рейтинг: Цена: 23220.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book describes the framework of the next generation of Business Information Services Library, BiSL(R). BiSL Next is a public domain standard for business information management with guiding principles, good practices and practical templates. It offers guidance for digitally engaged business leaders and those who collaborate with them, with the ultimate goal to improve business performance through better use of information and technology.Twelve elements - four drivers, four domains and four perspectives - are the basis of the guidance in BiSL Next. Target audience of this book are business managers, business information managers, business analysts, CIO`s and IT managers, as well as consultants in this field.While describing the twelve elements, the book offers them insight in the best way to manage, execute and profit from business information management in their enterprise. The book is also the official literature for the BiSL(R) Next Foundation exam.
Автор: Quarrell, Oliver (consultant In Clinical Genetics, Sheffield Children`s Hospital, Sheffield, Uk) Название: Huntington`s disease ISBN: 0198844387 ISBN-13(EAN): 9780198844389 Издательство: Oxford Academ Рейтинг: Цена: 19000.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Huntington`s disease (HD) is a genetically inherited condition resulting in severe nerve-cell damage in the brain. Written for patients and their families, this book explains the features of HD, the role of genetics, and advice on managing symptoms.
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