Behavioral Neurobiology of GABAB Receptor Function, Vlachou

Автор: Colombo Giancarlo
Название: Gabab Receptor
ISBN: 3319834282 ISBN-13(EAN): 9783319834283
Издательство: Springer
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Цена: 139750.00 T
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Описание: An up-to-date comprehensive overview of the GABA B receptor system with a particular focus on the most recent therapeutic applications and potential. This receptor system has recently been implicated in several diseases and disorders including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. This overview provides a translational perspective on the potential of the GABA B receptor pharmacology.

Автор: Jeanelle Portelli; Ilse Smolders
Название: Central Functions of the Ghrelin Receptor
ISBN: 1493955349 ISBN-13(EAN): 9781493955343
Издательство: Springer
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Цена: 130590.00 T
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Описание: The Ghrelin receptor was identified before its natural ligand ghrelin.

Автор: Vlachou Styliani, Wickman Kevin
Название: Behavioral Neurobiology of GABAB Receptor Function
ISBN: 3030913341 ISBN-13(EAN): 9783030913342
Издательство: Springer
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Цена: 139750.00 T
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Описание: It has been almost forty years since Norman G. Bowery discovered and named this “non-GABAA” receptor the GABAB receptor. It has been almost ten years since the last comprehensive book presentation focused on GABAB receptors. The main goal of this book is to provide the field with a contemporary and comprehensive perspective on the GABAB receptor, its physiological relevance, and its therapeutic potential. The volume is organized into introductory and special interest sections presented by experts who study the GABAB receptor from structural, signaling, pharmacologic, physiological, pathophysiological, and therapeutic perspectives. The book aims to appeal to a broad spectrum of biomedical and clinical scientists - any scholars with an interest in GABAB receptor. The editors hope readers find this work to be thought-provoking, instructive, and informative.

Автор: Blackburn, Thomas
Название: Gabab Receptor Pharmacology: A Tribute To Norman Bowery,58
ISBN: 0123786479 ISBN-13(EAN): 9780123786470
Издательство: Elsevier Science
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Цена: 185270.00 T
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Описание: A monograph that provides a perspective of current research, both basic and translational in the discovery of drugs acting at the GABAB receptor. It includes articles written by investigators in the field. It informs on the various developments.

Автор: Olimpia Meucci
Название: Chemokine Receptors and NeuroAIDS
ISBN: 1489984879 ISBN-13(EAN): 9781489984876
Издательство: Springer
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Цена: 158380.00 T
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Описание: Since their discovery as HIV co-receptors in 1996, chemokine receptors have been widely studied within the field of HIV pathogenesis, including neuroAIDS. However, though their role in infection of target cells and in inflammatory/immune responses is relatively well-characterized, their relevance with respect to neuropathogenesis is still unclear.

Автор: Jeanelle Portelli; Ilse Smolders
Название: Central Functions of the Ghrelin Receptor
ISBN: 1493908227 ISBN-13(EAN): 9781493908226
Издательство: Springer
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Цена: 158380.00 T
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Описание: The Ghrelin receptor was identified before its natural ligand ghrelin. This receptor is found both centrally and peripherally, and has been shown to affect various processes, such as food intake, gut motility, memory, glucose and lipid metabolism, cardiovascular performances, reproduction, memory, and immunological responses, amongst others. The functions of the ghrelin receptor in the central nervous system are numerous and are still being explored. In this book we specifically focus on the various roles of the ghrelin receptor in the central nervous system. In a first set of chapters, the book will focus on the discovery and the properties of this intriguing constitutively active G-protein coupled receptor, on its multiple intracellular transduction mechanisms and the various subtypes of the currently known ghrelin receptor complexes. Next, the book will elaborate on the mitochondrial mechanisms regulated by the ghrelin receptor, its role in feeding and drug addictive mechanisms, memory, sleep and arousal. The final chapters focus on the potential of this receptor as a target for the treatment of neurological disorders including Parkinson’s disease, epilepsy, anxiety and depression.

Автор: Katharine Herrick-Davis; Graeme Milligan; Giuseppe
Название: G-Protein-Coupled Receptor Dimers
ISBN: 3319601725 ISBN-13(EAN): 9783319601724
Издательство: Springer
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Цена: 186330.00 T
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Описание: G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses.

Автор: Kim Neve
Название: Functional Selectivity of G Protein-Coupled Receptor Ligands
ISBN: 1493961160 ISBN-13(EAN): 9781493961160
Издательство: Springer
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Цена: 174130.00 T
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Описание: In Functional Selectivity of G Protein-Coupled Receptors, experts review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon.

Автор: Katharine Herrick-Davis; Graeme Milligan; Giuseppe
Название: G-Protein-Coupled Receptor Dimers
ISBN: 3319867954 ISBN-13(EAN): 9783319867953
Издательство: Springer
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Цена: 139750.00 T
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Описание: G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses.

Автор: Boileau
Название: Therapeutic Applications of Dopamine D3 Receptor Function
ISBN: 3031230574 ISBN-13(EAN): 9783031230578
Издательство: Springer
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Цена: 139750.00 T
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Описание: The CTBN volume Therapeutic Applications of Dopamine D3 Receptor Function reviews the state of the knowledge on the dopamine D3 receptor and its role in human behavior and disease (i.e.: neuropsychiatric illnesses including schizophrenia, mood disorders, Parkinson’s disease, restless legs syndrome, addictions and substance use disorders). The volume is written by leading experts across multidisciplinary areas (imaging, biobehavioral testing and clinical trials, preclinical models / molecular pharmacology) converging on the therapeutic implications / potential of the D3 receptor. The D3 dopamine receptor is a member of the D2-like family of G protein-coupled receptors. It was cloned and characterized almost 25 years ago. A key feature of the D3 dopamine receptor system, which has attracted considerable attention, is its anatomical localization remarkably restricted to the limbic circuitry. This has spurred the hypothesis that D3 involvement could contribute to the pathophysiology of neuropsychiatric disorders (or to some features of neuropsychiatric disorders), including but not limited to psychosis, addictions and substance abuse, mood and movement disorders.

Автор: Alfred Maelicke
Название: Nicotinic Acetylcholine Receptor
ISBN: 3642716512 ISBN-13(EAN): 9783642716515
Издательство: Springer
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Цена: 121110.00 T
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Описание: Proceedings of the NATO Advanced Research Workshop on Mechanism of Action of the Nicotinic Acetylcholine Receptors held on the Island of Santorini, Greece, May 19-23, 1986

Автор: Foreman J.
Название: Textbook of Receptor Pharmacology
ISBN: 0849310296 ISBN-13(EAN): 9780849310294
Издательство: Taylor&Francis
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Цена: 87790.00 T
Наличие на складе: Нет в наличии.
Описание: The bestselling first edition of Textbook of Receptor Pharmacology originated from a renowned course in receptor pharmacology taught at the University College of London for the past three decades. Its innovative format united four major approaches to the study of receptors: molecular biology, quantitative functional studies of agonists and antagonists, ligand binding, and signal transduction systems. The second edition builds on this foundation.This edition streamlines the material and focuses on cell membrane receptors along with their immediate signal transducers. The section on the molecular structure of receptors reflects the advances in this area. This edition also includes two restructured new chapters, one on G-proteins and one on tyrosine kinases, as signal transductors. Several chapters also contain problems for students to solve as well as worked-out solutions.The book contains over one hundred useful diagrams and tables to aid illustration of concepts and a helpful appendix explaining the simple mathematics used in the text. A time-saving resource and comprehensive textbook, Textbook of Receptor Pharmacology, Second Edition provides in-depth, up-to-date coverage of this