Behavioral Neurobiology of GABAB Receptor Function, Vlachou Styliani, Wickman Kevin

Автор: Colombo Giancarlo
Название: Gabab Receptor
ISBN: 3319834282 ISBN-13(EAN): 9783319834283
Издательство: Springer
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Цена: 139750.00 T
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Описание: An up-to-date comprehensive overview of the GABA B receptor system with a particular focus on the most recent therapeutic applications and potential. This receptor system has recently been implicated in several diseases and disorders including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. This overview provides a translational perspective on the potential of the GABA B receptor pharmacology.

Автор: Blackburn, Thomas
Название: Gabab Receptor Pharmacology: A Tribute To Norman Bowery,58
ISBN: 0123786479 ISBN-13(EAN): 9780123786470
Издательство: Elsevier Science
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Цена: 185270.00 T
Наличие на складе: Поставка под заказ.
Описание: A monograph that provides a perspective of current research, both basic and translational in the discovery of drugs acting at the GABAB receptor. It includes articles written by investigators in the field. It informs on the various developments.

Автор: Emily M. Jutkiewicz
Название: Delta Opioid Receptor Pharmacology and Therapeutic Applications
ISBN: 303006980X ISBN-13(EAN): 9783030069803
Издательство: Springer
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Цена: 107130.00 T
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Описание: This volume describes our current understanding of the biological role of the delta-opioid receptor (DOR) system, focusing on its unique mechanisms of receptor trafficking and signaling in disease states. Part 1 covers the endogenous ligands that regulate the DOR system as well as novel compounds and therapies used to modulate the DOR system. Part 2 describes new insights into the localization and trafficking of the DOR and how ligand-directed signaling alters the fate of the receptor. Part 3 concentrates on the potential role of the DOR system in disease states, such as pain, mood, addiction, and Parkinson’s disease. Throughout the book, the DOR system as a target for drug development will be discussed.

Автор: Bernd Nilius; Veit Flockerzi
Название: Mammalian Transient Receptor Potential (TRP) Cation Channels
ISBN: 3662512238 ISBN-13(EAN): 9783662512234
Издательство: Springer
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Цена: 330870.00 T
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Описание: This book offers up-to-date information on the molecular and functional properties and pharmacology of mammalian Transient Receptor Potential channels, from close-up views of single protein/channels to broader principles of function and important pathologies.

Автор: Kamilla Swiech; Kelen Cristina Ribeiro Malmegrim;
Название: Chimeric Antigen Receptor T Cells
ISBN: 1071601458 ISBN-13(EAN): 9781071601457
Издательство: Springer
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Цена: 79190.00 T
Наличие на складе: Поставка под заказ.
Описание: This volume provides comprehensive methods from expert scientists working in the Chimeric Antigen Receptor T Cell (CAR-T Cell) field. Chapters guide readers through the state-of-art of CAR-T cell technology, CAR design and vector production, CAR-T cell generation and manufacturing, CAR-T cell characterization, and quality control. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chimeric Antigen Receptor T Cells: Development and Production aims to be useful in the production of CAR-T cells, especially for therapeutic purposes.

Автор: Mei-Chuan Ko; Girolamo Cal?
Название: The Nociceptin/Orphanin FQ Peptide Receptor
ISBN: 3030201856 ISBN-13(EAN): 9783030201852
Издательство: Springer
Рейтинг:
Цена: 139750.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The aim of this book is not only to introduce readers with a broad spectrum of biological actions of the NOP receptor, but also to feature a detailed look at the N/OFQ-NOP receptor system, medicinal chemistry, pharmacology, and clinical data of NOP-targeted ligands. This special volume book - for the first time focusing on the NOP receptor - is designed to serve as a useful reference, stimulate more research on the N/OFQ-NOP receptor system, and lead to more development of NOP-related ligands for several therapeutic applications.

Автор: Jeanelle Portelli; Ilse Smolders
Название: Central Functions of the Ghrelin Receptor
ISBN: 1493955349 ISBN-13(EAN): 9781493955343
Издательство: Springer
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Цена: 130590.00 T
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Описание: The Ghrelin receptor was identified before its natural ligand ghrelin.

Автор: Foreman J.
Название: Textbook of Receptor Pharmacology
ISBN: 0849310296 ISBN-13(EAN): 9780849310294
Издательство: Taylor&Francis
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Цена: 87790.00 T
Наличие на складе: Нет в наличии.
Описание: The bestselling first edition of Textbook of Receptor Pharmacology originated from a renowned course in receptor pharmacology taught at the University College of London for the past three decades. Its innovative format united four major approaches to the study of receptors: molecular biology, quantitative functional studies of agonists and antagonists, ligand binding, and signal transduction systems. The second edition builds on this foundation.This edition streamlines the material and focuses on cell membrane receptors along with their immediate signal transducers. The section on the molecular structure of receptors reflects the advances in this area. This edition also includes two restructured new chapters, one on G-proteins and one on tyrosine kinases, as signal transductors. Several chapters also contain problems for students to solve as well as worked-out solutions.The book contains over one hundred useful diagrams and tables to aid illustration of concepts and a helpful appendix explaining the simple mathematics used in the text. A time-saving resource and comprehensive textbook, Textbook of Receptor Pharmacology, Second Edition provides in-depth, up-to-date coverage of this

Автор: F. Cattabeni
Название: Principles and Methods in Receptor Binding
ISBN: 147571579X ISBN-13(EAN): 9781475715798
Издательство: Springer
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Цена: 46570.00 T
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Описание: " This NATO-ASI on "Principles and Methods in Receptor Binding" was devoted mainly to the following aspects of the study of receptors: the principles underlying the use of the binding technique;

Автор: Gurevich Vsevolod V., Gurevich Eugenia V., Tesmer John J. G.
Название: G Protein-Coupled Receptor Kinases
ISBN: 1493981420 ISBN-13(EAN): 9781493981427
Издательство: Springer
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Цена: 93160.00 T
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Описание: This collection explores up-to-date descriptions of known G protein-coupled receptor kinase (GRK)-dependent mechanisms, both associated with G protein-coupled receptor (GPCR) functions and the receptor-independent. The chapters cover a wide range of studies from invertebrates to humans, with sections of the volume covering GRK structure, mechanisms of activation, and interaction with GPCRs, GRKs in cell signaling, as well as physiological and pathophysiological mechanisms regulated by GRKs. Written for the Methods in Pharmacology and Toxicology series, this book features the kind of practical detail necessary for success in the laboratory. Authoritative and timely, G Protein-Coupled Receptor Kinases features the kind of comprehensive mechanistic elucidation of GRK functions and their regulation in cells necessary for a better understanding of cell biology as well as for devising novel research approaches and therapeutic strategies.

Автор: Alfred Maelicke
Название: Nicotinic Acetylcholine Receptor
ISBN: 3642716512 ISBN-13(EAN): 9783642716515
Издательство: Springer
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Цена: 121110.00 T
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Описание: Proceedings of the NATO Advanced Research Workshop on Mechanism of Action of the Nicotinic Acetylcholine Receptors held on the Island of Santorini, Greece, May 19-23, 1986

Автор: Gabriela K. Popescu
Название: Ionotropic Glutamate Receptor Technologies
ISBN: 1493928112 ISBN-13(EAN): 9781493928118
Издательство: Springer
Рейтинг:
Цена: 139750.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This detailed volume explores key technologies that are used currently to investigate iGluR structure, function and physiology.