Название: Metastasis ISBN: 1621823245 ISBN-13(EAN): 9781621823247 Издательство: Неизвестно Рейтинг: Цена: 49140.00 T Наличие на складе: Невозможна поставка. Описание: Nearly all types of cancer have the ability to metastasize, or spread from one organ or tissue in the body to another. Metastatic disease is responsible for the majority of cancer deaths and, therefore, is a critical area of research. Work to better understand the metastatic cascade-how cells detach from a primary tumor, migrate through the body, and seed secondary tumors at distant locations-will lead to improved treatment options for patients with cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding the molecular mechanisms underlying metastasis and how this knowledge is paving the way for new therapeutic targets. The contributors discuss progress in defining mutations that might be driving metastasis, the formation of a premetastatic niche and how it enhances the establishment of a secondary tumor, and how changes that occur during aging increase the metastatic capacity of tumor cells. They also consider the selection and colonization of common target organs (e.g., brain, liver, and bones) during metastasis and the roles of immune cells and extracellular vesicles at different steps of the metastatic cascade. Cellular plasticity-including evidence for metastatic stem cells and the role of tumor cell dormancy in recurrent metastasis-is also covered. In addition, the authors describe the development of in vivo models and techniques for studying metastasis, methods for monitoring tumor progression and metastatic spread (e.g., intravital microscopy and liquid biopsy), and immunotherapies that can potentially target cancer metastasis. This volume is therefore a vital reference for all cancer biologists and clinician-scientists concerned with defeating cancer.
Автор: Michael W. Retsky; Romano Demicheli Название: Perioperative Inflammation as Triggering Origin of Metastasis Development ISBN: 3319579428 ISBN-13(EAN): 9783319579429 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The book will explain previously unconnected clinical data such as why mammography works better for women age 50-59 than it does for women age 40-49, why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes, and it may also explain the racial disparity in outcome.
Автор: Retsky Michael W., Demicheli Romano Название: Perioperative Inflammation as Triggering Origin of Metastasis Development ISBN: 3319862898 ISBN-13(EAN): 9783319862897 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The book will explain previously unconnected clinical data such as why mammography works better for women age 50-59 than it does for women age 40-49, why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes, and it may also explain the racial disparity in outcome.
Автор: Maru Название: Inflammation and Metastasis ISBN: 4431567569 ISBN-13(EAN): 9784431567561 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Нет в наличии. Описание: This book provides the latest information on cancer metastasis from the standpoint of inflammation, especially innate immune reactions caused by endogenous mediators but not exogenous pathogens, with ideas on how to understand the complicated mechanisms of metastasis as well as to interpret therapeutic targets. The book includes the topic of the emerging roles of endogenous TLR4 ligands whose functions are shared intriguingly by metastasis and auto-inflammatory diseases such as rheumatoid arthritis. For example, most cancer therapies established so far are effective initially. However, they eventually face the great obstacles of drug resistance, immune evasion, and metastatic progression. One of the endogenous TLR4 ligands is thought to contribute to all three processes. The most important features of the book are to explain a concept of homeostatic inflammation, disturbance of which in the lungs gives rise to the establishment of a pre-metastatic pulmonary microenvironment based on primary tumor-mediated hijacking of the innate immune defense system against respiratory infection. In addition, structure-based thinking is another important feature of this book. It is proposed that inflammation forms a functional triangle with angiogenesis and coagulation, in the center of which cancer is located. Given the proposal of precision medicine by President Obama in the United States in 2015 and the recent success of immune-modulator-based therapy, this book will appeal to researchers in a variety of fields with the title of the book connecting the worst disease (metastasis) and the most fundamental event (inflammation) that is common to many diseases.
Автор: Fatatis Название: Signaling Pathways and Molecular Mediators in Metastasis ISBN: 940178258X ISBN-13(EAN): 9789401782586 Издательство: Springer Рейтинг: Цена: 148010.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book reviews and analyzes new techniques for identifying molecules and signalling pathways that play an important role in metastasis, and offers a broad perspective on similarities and discrepancies among the dissemination of several solid malignancies.
Автор: Pnina Brodt Название: Liver Metastasis: Biology and Clinical Management ISBN: 9400735456 ISBN-13(EAN): 9789400735453 Издательство: Springer Рейтинг: Цена: 191550.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Despite recent advances in surgery, and more aggressive resection, liver metastases still prove fatal in a high proportion of cases. This volume aims to enhance our understanding of the biology of hepatic cancer metastasis, in particular its early stages.
Автор: Ursula G?nthert; Walter Birchmeier Название: Attempts to Understand Metastasis Formation II ISBN: 3642646980 ISBN-13(EAN): 9783642646980 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In metastasis, tumor cells disseminate from the primary lesion and home to secondary organs where they may remain dormant for a long time. Metastasis formation is still the most feared manifestation for tumor patients and clinicians. Although improvements have been made concerning earlier detection and specific therapy, most of the cancer patients still die ot distant metastases. The purpose of these three volumes is to review the recent progress in molecular metas- tasis research and to attempt to further understand the biol- ogy of this multifocal process. With respect to present day molecular biology, the pioneers of metastasis research established the basic concepts of metasta- sis formation in the 1970s and 1980s, namely, clonal selection of metastatic cells, heterogeneity of metastatic subpopulations, organ specificity of metastasis and the importance of angio- genesis (Fidler, Kripke, Nicolson, Folkman and others). In the 1980s and 1990s, several of the molecules involved were identified and their network interactions elucidated. These three volumes of Current Topics in Microbiology and Immuno- logy compile the most recent developments on these meta- stasis-related molecules; their interactions, regulation, and ways to interfere with their action. It became evident that metastasis-related molecules are confined to distinct cellular compartments, such as the extracellular space, the cell membrane, the cytoplasmic signalling network, and the nuclear regulatory system. For the complex tnetastatic cascade, proteolysis and alterations in adhesive functions are the most obvious and thus one of the most thoroughly investigated processes.
Автор: Galluzzi Lorenzo, Thomas Clement Название: Actin Cytoskeleton in Cancer Progression and Metastasis - Part C ISBN: 0128241381 ISBN-13(EAN): 9780128241387 Издательство: Elsevier Science Рейтинг: Цена: 209980.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Actin Cytoskeleton in Cancer Progression and Metastasis - Part C, Volume 358 in the International Review of Cell and Molecular Biology series, provides an overview of the roles of the actin cytoskeleton and some of its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. New chapters cover Actin isoforms in cancer, Actin cytoskeleton regulators at invadopodia, Cytoskeletal Mechanics Drives Heterogeneity in Epithelial Ovarian Cancer, and more.
Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biology
Offers a wide range of perspectives for basic and translational research
Discusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications
Автор: Stock Christian, Pardo Luis A. Название: From Malignant Transformation to Metastasis: Ion Transport in Tumor Biology ISBN: 3030997995 ISBN-13(EAN): 9783030997991 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This second book of the three-volume collection "Ion Transport in Tumor Biology" helps readers gain comprehensive knowledge of the pathophysiology of cancer.
Автор: Miriam Dwek; Susan A. Brooks; Udo Schumacher Название: Metastasis Research Protocols ISBN: 1493956310 ISBN-13(EAN): 9781493956319 Издательство: Springer Рейтинг: Цена: 111790.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Now in a second, revised edition, this practical companion to the methodologies of researching cancer growth includes topical introductions and stepwise, reproducible protocols for laboratory processes, as well as invaluable troubleshooting tips.
Автор: Tracey A. Martin; Wen G. Jiang Название: Tight Junctions in Cancer Metastasis ISBN: 9400798067 ISBN-13(EAN): 9789400798069 Издательство: Springer Рейтинг: Цена: 148010.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book summarizes current knowledge of tight junctions and their role in cancer and cancer metastasis. Coverage includes fundamental changes in tight junctions in the process of cancer development and the importance of cellular structure in drug therapy.
Автор: Domenico Ribatti Название: The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis ISBN: 9400791577 ISBN-13(EAN): 9789400791572 Издательство: Springer Рейтинг: Цена: 104480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: 1. Introduction 2. Chorioallantoic membrane and its embryological origin 2.1. Morphology of chorioallantoic membrane blood and lymphatic vessels 2.2. A single blood sinus or a capillary plexus beneath the chorionic epithelium? 2.3. The chorioallantoic membrane vascular growth 3. Use of chorioallantoic membrane in the study of angiogenic molecules 3.1. Role of FGF-2 in chorioallantoic membrane vascularization 4. Use of chorioallantoic membrane in the study of antiangiogenic molecules 5. Use of chorioallantoic membranes in the study of tumor angiogenesis 5.1. Angiogenesis and antiangiogenesis in multiple myeloma 5.2. Angiogenesis and antiangiogenesis in human neuroblastoma 6. Use of chorioallantoic membrane in the study of tumor metastasis 6.1. Spontaneous metastasis models. 6.2. Experimental metastasis studies. 7. Other applications 7.1. In ovo and ex ovo methods 7.2. Use of chorioallantoic membrane in the study of tumor lymphangiogenesis 8. Different morphological techniques that can be used to study vascularization of the CAM and the genes involved. 9. Methods of quantifying the angiogenic response 10. Limitations of the chorioallantoic membrane assay 11. Other classical in vivo assays in comparison (advantages, disadvantages and limitations) with the chorioallantoic membrane 12. Concluding remarks Acknowledgments References
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