Inflammation and Metastasis, Maru

Название: Metastasis
ISBN: 1621823245 ISBN-13(EAN): 9781621823247
Издательство: Неизвестно
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Цена: 49140.00 T
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Описание: Nearly all types of cancer have the ability to metastasize, or spread from one organ or tissue in the body to another. Metastatic disease is responsible for the majority of cancer deaths and, therefore, is a critical area of research. Work to better understand the metastatic cascade-how cells
detach from a primary tumor, migrate through the body, and seed secondary tumors at distant locations-will lead to improved treatment options for patients with cancer.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding the molecular mechanisms underlying metastasis and how this knowledge is paving the way for new therapeutic targets. The
contributors discuss progress in defining mutations that might be driving metastasis, the formation of a premetastatic niche and how it enhances the establishment of a secondary tumor, and how changes that occur during aging increase the metastatic capacity of tumor cells. They also consider the
selection and colonization of common target organs (e.g., brain, liver, and bones) during metastasis and the roles of immune cells and extracellular vesicles at different steps of the metastatic cascade. Cellular plasticity-including evidence for metastatic stem cells and the role of tumor cell
dormancy in recurrent metastasis-is also covered.

In addition, the authors describe the development of in vivo models and techniques for studying metastasis, methods for monitoring tumor progression and metastatic spread (e.g., intravital microscopy and liquid biopsy), and immunotherapies that can potentially target cancer metastasis. This volume
is therefore a vital reference for all cancer biologists and clinician-scientists concerned with defeating cancer.

Автор: Michael W. Retsky; Romano Demicheli
Название: Perioperative Inflammation as Triggering Origin of Metastasis Development
ISBN: 3319579428 ISBN-13(EAN): 9783319579429
Издательство: Springer
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Цена: 149060.00 T
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Описание: The book will explain previously unconnected clinical data such as why mammography works better for women age 50-59 than it does for women age 40-49, why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes, and it may also explain the racial disparity in outcome.

Автор: Retsky Michael W., Demicheli Romano
Название: Perioperative Inflammation as Triggering Origin of Metastasis Development
ISBN: 3319862898 ISBN-13(EAN): 9783319862897
Издательство: Springer
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Цена: 139750.00 T
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Описание: The book will explain previously unconnected clinical data such as why mammography works better for women age 50-59 than it does for women age 40-49, why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes, and it may also explain the racial disparity in outcome.

Автор: Maru Yoshiro
Название: Inflammation and Metastasis
ISBN: 9811617562 ISBN-13(EAN): 9789811617560
Издательство: Springer
Цена: 186330.00 T
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Описание: This book, now in a thoroughly revised and updated second edition, provides the latest information on cancer metastasis from the perspective of inflammation and presents new ideas on the complicated mechanisms of metastasis and potential therapeutic targets.

Автор: Fatatis
Название: Signaling Pathways and Molecular Mediators in Metastasis
ISBN: 940178258X ISBN-13(EAN): 9789401782586
Издательство: Springer
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Цена: 148010.00 T
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Описание: This book reviews and analyzes new techniques for identifying molecules and signalling pathways that play an important role in metastasis, and offers a broad perspective on similarities and discrepancies among the dissemination of several solid malignancies.

Автор: Pnina Brodt
Название: Liver Metastasis: Biology and Clinical Management
ISBN: 9400735456 ISBN-13(EAN): 9789400735453
Издательство: Springer
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Цена: 191550.00 T
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Описание: Despite recent advances in surgery, and more aggressive resection, liver metastases still prove fatal in a high proportion of cases. This volume aims to enhance our understanding of the biology of hepatic cancer metastasis, in particular its early stages.

Автор: Ursula G?nthert; Walter Birchmeier
Название: Attempts to Understand Metastasis Formation II
ISBN: 3642646980 ISBN-13(EAN): 9783642646980
Издательство: Springer
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Цена: 121110.00 T
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Описание: In metastasis, tumor cells disseminate from the primary lesion and home to secondary organs where they may remain dormant for a long time. Metastasis formation is still the most feared manifestation for tumor patients and clinicians. Although improvements have been made concerning earlier detection and specific therapy, most of the cancer patients still die ot distant metastases. The purpose of these three volumes is to review the recent progress in molecular metas- tasis research and to attempt to further understand the biol- ogy of this multifocal process. With respect to present day molecular biology, the pioneers of metastasis research established the basic concepts of metasta- sis formation in the 1970s and 1980s, namely, clonal selection of metastatic cells, heterogeneity of metastatic subpopulations, organ specificity of metastasis and the importance of angio- genesis (Fidler, Kripke, Nicolson, Folkman and others). In the 1980s and 1990s, several of the molecules involved were identified and their network interactions elucidated. These three volumes of Current Topics in Microbiology and Immuno- logy compile the most recent developments on these meta- stasis-related molecules; their interactions, regulation, and ways to interfere with their action. It became evident that metastasis-related molecules are confined to distinct cellular compartments, such as the extracellular space, the cell membrane, the cytoplasmic signalling network, and the nuclear regulatory system. For the complex tnetastatic cascade, proteolysis and alterations in adhesive functions are the most obvious and thus one of the most thoroughly investigated processes.

Автор: Stock Christian, Pardo Luis A.
Название: From Malignant Transformation to Metastasis: Ion Transport in Tumor Biology
ISBN: 3030997995 ISBN-13(EAN): 9783030997991
Издательство: Springer
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Цена: 130430.00 T
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Описание: This second book of the three-volume collection "Ion Transport in Tumor Biology" helps readers gain comprehensive knowledge of the pathophysiology of cancer.

Автор: Dwek
Название: Metastasis Research Protocols
ISBN: 1461482437 ISBN-13(EAN): 9781461482437
Издательство: Springer
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Цена: 139750.00 T
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Описание: This new edition offers updates and important new techniques for illuminating the processes underlying research on metastasis. Presents techniques applicable to living cells and tissues, to cell behavior in vitro, to animal models and mathematical constructs.

Автор: Wen-Sheng Wu; Chi-Tan Hu
Название: Signal Transduction in Cancer Metastasis
ISBN: 9400733585 ISBN-13(EAN): 9789400733589
Издательство: Springer
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Цена: 186340.00 T
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Описание: This book examines the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. It highlights the initial stage of tumor metastasis.

Автор: Stanley P. L. Leong
Название: Cancer Metastasis and the Lymphovascular System:
ISBN: 1489991026 ISBN-13(EAN): 9781489991027
Издательство: Springer
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Цена: 186330.00 T
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Описание: Sentinel lymph node (SLN) procedures have opened a window of opportunity for the study of micrometastasis. In eighty percent (80%) of metastasis there lies an orderly pattern of progression via the lymphatic network, while 20% of the time systemic metastasis occurs, bypassing the lymphatic system. During the past two decades, significant progress has been achieved in understanding the anatomical, functional, cellular and molecular aspects of the lymphovascular system and the metastasis process. · Molecular imaging advances help to localize early cancers more precisely. · Current status of the immune responses in the draining lymph nodes against cancer is summarized. · New paradigms of early cancer growth, proliferation, overcoming apoptosis are exploited in the development of anticancer treatment. In this book, basic scientists and clinicians exchange ideas so that laboratory findings can be applied to clinical dilemmas, and clinical problems can be targeted for research in the laboratory.