Автор: Lovestone Название: Biomarkers in Brain Disease ISBN: 1573317721 ISBN-13(EAN): 9781573317726 Издательство: Wiley Рейтинг: Цена: 103230.00 T Наличие на складе: Поставка под заказ. Описание: Advances in biomarker development are revolutionizing the way we study, diagnose and treat disease. However, progress in the development and use of biomarkers for diseases of the central nervous system has been limited by a number of difficulties -- including the inherent barriers associated with studying the brain.
Автор: Alexander Birbrair Название: Pericyte Biology - Novel Concepts ISBN: 3030026000 ISBN-13(EAN): 9783030026004 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume explores novel concepts of pericyte biology. The present book is an attempt to describe the most recent developments in the area of pericyte biology which is one of the emergent hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of detailed chapters on what we know so far about the pericytes. Together with its companion volumes Pericyte Biology in Different Organs and Pericyte Biology in Disease, Pericyte Biology - Novel Concepts presents a comprehensive update on the latest information and most novel functions attributed to pericytes. To those researchers newer to this area, it will be useful to have the background information on these cells' unique history. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and researchers or clinicians involved with specific diseases.
Автор: Alexander Birbrair Название: Pericyte Biology in Different Organs ISBN: 3030110923 ISBN-13(EAN): 9783030110925 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The present book is an attempt to describe the most recent developments in the area of pericyte biology which is one of the emergent hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of thirteen detailed chapters on what we know so far about pericytes in distinct organs in physiological and pathological conditions. Further, it provides an update on the most novel functions attributed to these cells and will introduce a newer generation of researchers and scientists to the importance of these cells, ranging from their discovery in different organs through current state-of-the-science. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and vascular research. This volume explores pericytes' physiologic roles in different tissues, ranging from the pancreas, lungs and liver through skeletal muscle, gut, retina and more. Together with its companion volumes Pericyte Biology in Disease and Pericyte Biology – Novel Concepts, Pericyte Biology in Different Organs presents a comprehensive update on the latest information and most novel functions attributed to pericytes. To those researchers newer to this area, it will be useful to have the background information on these cells' unique history. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and researchers or clinicians involved with specific organs.
Автор: Orrenius Название: Mitochondrial Signaling in Health and Disease ISBN: 1439880026 ISBN-13(EAN): 9781439880029 Издательство: Taylor&Francis Рейтинг: Цена: 193950.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.
With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include:
Electron transport and energy production
Mitochondrial biogenesis and dynamics
Mitochondrial signaling
Apoptosis and autophagy
Pharmacology signaling
Epigenetic signaling: mitochondrial methylation and acetylation reactions
An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.
Автор: Jeffrey Warren Название: Caspases: Roles & Significance in Cell Death & Disease ISBN: 1536102474 ISBN-13(EAN): 9781536102475 Издательство: Nova Science Рейтинг: Цена: 122490.00 T Наличие на складе: Невозможна поставка. Описание: Caspases are proteases that are responsible for the initiation and execution of cell death pathways in developmental, inflammatory and pharmacological paradigms. Caspase activity is required for the execution of apoptotic cell death through the proteolytic cleavage of approximately one thousand substrates that result in the apoptotic phenotype. This book provides new research and discusses the roles and significance caspases have in cell death and disease.
Автор: DittmarDittmar Название: Stem Cell Biology in Health and Disease 2010 ISBN: 9048130395 ISBN-13(EAN): 9789048130399 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume examines the dual role of stem cells in health and disease. It details strategies on the use of embryonic stem cells and embryonic-like stem cells in regenerative medical purposes as well as strategies on the elimination of cancer stem cells.
Автор: Shetty Ashok K. Название: Neural Stem Cells in Health and Disease ISBN: 9814623172 ISBN-13(EAN): 9789814623179 Издательство: World Scientific Publishing Рейтинг: Цена: 103490.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book is a comprehensive guide on neural stem cell behavior in health and disease.
Автор: Ken S. Kosik; Dennis J. Selkoe Название: Alzheimer`s Disease: Lessons from Cell Biology ISBN: 3642794254 ISBN-13(EAN): 9783642794254 Издательство: Springer Рейтинг: Цена: 139310.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Like the unflinching gaze of Captain Ahab walking the deck of the Pequod, Alzheimer researchers have had their sights fixed firmly on the disease for many years. Perhaps for most of the years since the first descriptions of the disease in 1907, the science of Alzheimer`s disease was descriptive, and lay in the province of pathologists.
Автор: Shetty, Nandini Tang, Julian W. Andrews, Julie Название: Infectious disease ISBN: 1405135433 ISBN-13(EAN): 9781405135436 Издательство: Wiley Рейтинг: Цена: 77030.00 T Наличие на складе: Поставка под заказ. Описание: "... a fun and readable book that engages the imagination and retains the interest of the clinically oriented reader while conveying an understanding of the direct implications of molecular characteristics of infectious agents to the practice of medicine.
Автор: Cameron Wagner Название: Endoplasmic Reticulum Stress: Regulation, Function & Role in Health & Disease ISBN: 1634855647 ISBN-13(EAN): 9781634855648 Издательство: Nova Science Цена: 122490.00 T Наличие на складе: Невозможна поставка. Описание: This book provides current research on the regulation, function and role in health and disease of endoplasmic reticulum (ER) stress. The first chapter focuses on evidence that supports the role of endoplasmic reticulum stress, mitochondria-associated membranes (MAMs) microdomain and oxidative stress during obesity as a molecular pathway to type 2 diabetes mellitus (T2DM) development. Also, it addresses protein missfolding and mitochondria function as potential targets to improve metabolic derangements in obesity and T2DM. Chapter Two summarizes and discusses the current understanding of molecular mechanisms linking ER stress to beta cell fate. Chapter Three depicts the association between eIF2α kinase-linked pathways and diet-linked pathogenic responses (such as ones caused by microbes or nutritional abnormalities). Chapter Four reviews placental endoplasmic reticulum stress in the determination of pregnancy outcome. The last chapter discusses the role of ER stress in meditating the anticancer effects of tocotrienols.
Автор: Albee Messing Название: Alexander Disease: A Guide for Patients and Families ISBN: 1615047646 ISBN-13(EAN): 9781615047642 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 45940.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book offers a comprehensive overview of Alexander disease, a rare and devastating neurological disorder that often affects the white matter of the brain and spinal cord.Its distinctive neuropathology consists of abundant Rosenthal fibers within astrocytes (one of the four major cell types of the central nervous system). Nearly all cases are caused by variants in the gene encoding the intermediate filament protein GFAP, but how these changes in GFAP lead to the widespread manifestations of disease is poorly understood.Astrocytes, while discovered over a century ago, are themselves still much of a mystery. They exhibit considerable diversity, defy precise definition, and yet actively regulate many aspects of nervous system functioning.We also have incomplete understanding of Rosenthal fibers, odd structures that contain GFAP as just one of many components. Whether they are toxic or protective is unknown. Moreover, Rosenthal fibers are not absolutely unique to Alexander disease, and are seen sporadically in a wide variety of other conditions, including brain tumors and multiple sclerosis.GFAP is the third unknown. It is an ancient protein, arising early in the evolution of vertebrates, but its role in normal biology is still a matter of debate. Yet Alexander disease shows, without a doubt, that changing just a single of its 432 amino acids can lead to catastrophe, not just in the astrocytes where GFAP is produced but also in the other cells with which astrocytes interact.Despite all of the unknowns, much has been learned in the past 20 years, and it is time to share this knowledge. This book is intended for recently diagnosed patients and families, as well as non-specialist researchers interested in this neurological disease. It covers historical origins, the state of current knowledge, and prospects for what lies ahead, with citations to the primary literature given throughout.
Автор: Natalya V Semiletova Название: Major Histocompatibility Complex: Biology, Functions & Roles in Disease ISBN: 1619429993 ISBN-13(EAN): 9781619429994 Издательство: Nova Science Рейтинг: Цена: 211190.00 T Наличие на складе: Невозможна поставка. Описание: Represents original findings and observations that were made on the role and function of MHC proteins in different laboratories around the globe. This title includes articles that cover topics from the importance of MHC diversity to the health of the wildlife to intimate molecular mechanisms of MHC exchange between cells.
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