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Mitochondrial Signaling in Health and Disease, Orrenius

Автор: Orrenius
Название:  Mitochondrial Signaling in Health and Disease   (Оррениус: Митохондриальные сигналы в норме и при заболевании)
Издательство: Taylor&Francis
Классификация:
Цитология
Клеточная биология

ISBN: 1439880026
ISBN-13(EAN): 9781439880029
ISBN: 1-439-88002-6
ISBN-13(EAN): 978-1-439-88002-9
Обложка/Формат: Hardback
Страницы: 528
Вес: 0.91 кг.
Дата издания: 20.06.2012
Серия: Oxidative stress and disease
Язык: ENG
Иллюстрации: 78 black & white illustrations, 10 colour illustrations, 6 black & white tables
Размер: 158 x 234 x 33
Читательская аудитория: Postgraduate, research & scholarly
Рейтинг:
Поставляется из: Англии
Описание: Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. This volume examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis. Topics include electron transport and energy production, mitochondrial biogenesis and dynamics, mitochondrial signaling, and apoptosis and autophagy. The book also explores pharmacology signaling and epigenetic signaling, with discussions on mitochondrial methylation and acetylation reactions. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.?
Дополнительное описание:

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Mitochondrial DNA / Methods and Protocols

Автор: Copeland William C.
Название: Mitochondrial DNA / Methods and Protocols
ISBN: 0896039722 ISBN-13(EAN): 9780896039728
Издательство: Springer
Цена: 46730 T
Наличие на складе: Поставка под заказ.
Описание: Internationally recognized authorities describe in great detail the methods they have perfected to analyze mtDNA and the proteins involved in its maintenance. The analytical techniques cover the purification of mtDNA from a variety of sources and the analysis of DNA for both deletions, point mutations, and damage, for replication intermediates, and for following the fate of mtDNA outside of the mitochondria. Additional analytical methods are presented for analyzing the proteins and enzymes that maintain mtDNA. Comprehensive and timely, Mitochondrial DNA: Methods and Protocols offers both basic and clinical researchers proven cutting-edge methods for analyzing mtDNA and illuminating the role it plays in the aging process, apoptosis, and possibly some cancers.

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Mitochondrial Disorders / From Pathophysiology to aquired defects

Автор: Desnuelle Claude, Di Mauro S.
Название: Mitochondrial Disorders / From Pathophysiology to aquired defects
ISBN: 228759759X ISBN-13(EAN): 9782287597596
Издательство: Springer
Цена: 37950 T
Наличие на складе: Поставка под заказ.
Описание: The concept of mitochondrial diseases originated in 1962 with the description by Luft and coworkers of a patient with nonthyroidal hypermetabolism due to loose coupling of oxidation and phosphorylation in muscle mitochondria. Over the following quarter of a century, thanks to W. King Engel's "ragged-red fibres" as convenient markers for mitochondrial pathology, numerous papers described clinical, morphological, and biochemical features of "mitochondrial myopathies". In 1988 the discovery of mutations in mitochondrial DNA led to an explosive expansion of research into mitochondrial disorders. Throughout the 1990s the rapid identification of multiple mitochondrial gene defects associated with clinically diverse disorders has left practitioners puzzled about diagnosing such heterogeneous and complex syndromes.Through updated data, this book discusses now what Luft aptly called "mitochondrial medicine". In so doing, it considers the pivotal role of mitochondria in drug sensitivity, their key roles in ageing, apoptosis, and neurodegeneration along with primary mitochondrial diseases due to mutations in the nuclear genome, in the mitochondrial genome, or in the cross-talk between the two genomes.

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Mitochondrial Function and Biogenesis

Автор: Koehler Carla M., Bauer Matthias F.
Название: Mitochondrial Function and Biogenesis
ISBN: 3540214895 ISBN-13(EAN): 9783540214892
Издательство: Springer
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Цена: 169620 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Mitochondria are complex organelles, possessing a double-membrane and even their own genome, the mtDNA. They play a pivotal role in cellular metabolism, respiration, and production of ATP essential for the normal function of all human organ systems. It is not surprising, therefore, that genetic defects of mitochondrial functions cause a wide spectrum of human diseases. This book provides the first modern and truly comprehensive coverage of the biochemistry, genetics, and pathology of mitochondria in different organisms. It particularly focuses on the recent advances in our understanding of basic mitochondrial research to the consequences of dysfunction at the molecular level. The 13 contributions written by leading researchers in the field include topics such as: mitochondrial genome evolution and mtDNA stability, mitochondrial biogenesis and protein quality control, mitochondrial morphology, assembly and function of the mitochondrial energy generation apparatus and mitochondrial metabolic pathways. These are particularly oriented to link in these various mitochondrial pathways to the clinical consequences of their dysfunctions.

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Drug-induced mitochondrial dysfunction

Название: Drug-induced mitochondrial dysfunction
ISBN: 0470111313 ISBN-13(EAN): 9780470111314
Издательство: Wiley
Рейтинг:
Цена: 92920 T
Наличие на складе: Поставка под заказ.
Описание: Offers a resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. This title discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function.

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Mitochondrial Function in Lung Health and Disease

Автор: Natarajan
Название: Mitochondrial Function in Lung Health and Disease
ISBN: 1493908286 ISBN-13(EAN): 9781493908288
Издательство: Springer
Рейтинг:
Цена: 65990 T
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Описание: Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling.

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Mitochondrial DNA, Mitochondria, Disease and Stem Cells

Автор: St. John
Название: Mitochondrial DNA, Mitochondria, Disease and Stem Cells
ISBN: 1627031006 ISBN-13(EAN): 9781627031004
Издательство: Springer
Рейтинг:
Цена: 92510 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next.

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Mitochondrial Mechanisms of Degeneration and Repair in Parkinson`s Disease

Автор: Buhlman
Название: Mitochondrial Mechanisms of Degeneration and Repair in Parkinson`s Disease
ISBN: 3319421379 ISBN-13(EAN): 9783319421377
Издательство: Springer
Рейтинг:
Цена: 87380 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume brings together various theories of how aberrations in mitochondrial function and morphology contribute to neurodegeneration in idiopathic and familial forms of Parkinson’s disease. Moreover, it comprehensively reviews the current search for therapies, and proposes how molecules are involved in specific functions as attractive therapeutic targets. It is expected to facilitate critical thought and discussion about the fundamental aspects of neurodegeneration in Parkinson’s disease and foster the development of therapeutic strategies among researchers and graduate students. Theories of idiopathic Parkinson’s etiology support roles for chronic inflammation and exposure to heavy metals or pesticides. Interestingly, as this project proposes, a case can be made that abnormalities in mitochondrial morphology and function are at the core of each of these theories. In fact, the most common approach to the generation of animal and cell-culture models of idiopathic Parkinson’s disease involves exposure to mitochondrial toxins. Even more compelling is the fact that most familial patients harbor genetic mutations that cause disruptions in normal mitochondrial morphology and function. While there remains to be no effective treatment for Parkinson’s disease, efforts to postpone, prevent and “cure” onset mitochondrial aberrations and neurodegeneration associated with Parkinson’s disease in various models are encouraging. While only about ten percent of Parkinson’s patients inherit disease-causing mutations, discovering common mechanisms by which familial forms of Parkinson’s disease manifest will likely shed light on the pathophysiology of the more common idiopathic form and provide insight to the general process of neurodegeneration, thus revealing therapeutic targets that will become more and more accessible as technology improves.

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Conceptual background and bioenergetic/mitochondrial aspects of o

Автор: Lorenzo Galluzzi
Название: Conceptual background and bioenergetic/mitochondrial aspects of o
ISBN: 0124166180 ISBN-13(EAN): 9780124166189
Издательство: Elsevier Science
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Цена: 85250 T
Наличие на складе: Поставка под заказ.
Описание: Volume 542 of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This new volume covers research methods providing a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as "yet another" general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation.

  • Continues the legacy of this premier serial with quality chapters authored by leaders in the field
  • Covers research methods in biomineralization science
  • Provides theoretical overview on metabolic alterations of cancer cells, and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo

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Human Mitochondrial DNA and the Evolution of Homo sapiens

Автор: Hans-J?rgen Bandelt; Martin Richards; Vincent Maca
Название: Human Mitochondrial DNA and the Evolution of Homo sapiens
ISBN: 3642068685 ISBN-13(EAN): 9783642068683
Издательство: Springer
Рейтинг:
Цена: 102790 T
Наличие на складе: Поставка под заказ.
Описание: Mitochondrial DNA is one of the most closely explored genetic systems, because it can tell us so much about the human past. From molecular biology to anthropology, statistics to ancient DNA, this first volume of three presents a comprehensive global picture and a critical appraisal of human mitochondrial DNA variation.

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Mitochondrial Medicine

Автор: Gvozdjakova
Название: Mitochondrial Medicine
ISBN: 1402067135 ISBN-13(EAN): 9781402067136
Издательство: Springer
Рейтинг:
Цена: 136950 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Mitochondrial Medicine is an area where several disciplines from basic science to clinical medicine converge. Based upon data gathered over 30 years of clinical and experimental research, this book features internationally recognized authors who share their experience in various fields such as mitochondrial cardiology, neurology, and diabetology.

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Mitochondrial Medicine

Автор: Dimauro
Название: Mitochondrial Medicine
ISBN: 1842142887 ISBN-13(EAN): 9781842142882
Издательство: Informa
Рейтинг:
Цена: 87310 T
Наличие на складе: Нет в наличии.
Описание: Mitochondrial dysfunction is increasingly being recognized as the basis of a wide variety of human diseases. Providing an authoritative update on our knowledge of mitochondrial medicine, this text draws together world authorities from various fields to discuss general therapeutic strategies and the treatments. Coverage includes a range of specialties, including cardiology, ophthalmology, otology, nephrology, gastroenterology, hematology-oncology, and reproductive medicine. Accessible and user-friendly, the text also presents translational concepts of mitochondrial biogenesis and genetics in vignettes related to specific questions raised by the disease under discussion.

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Human Mitochondrial DNA and the Evolution of Homo sapiens

Автор: Bandelt
Название: Human Mitochondrial DNA and the Evolution of Homo sapiens
ISBN: 3540317880 ISBN-13(EAN): 9783540317883
Издательство: Springer
Рейтинг:
Цена: 102800 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Mitochondrial DNA is one of the most explored genetic systems because of what it can tell us about the human past. This volume takes a unique perspective, presenting the disparate strands that must be tied together to exploit this system. From molecular biology to anthropolo y, statistics to ancient DNA, this first volume of three presents the global picture of human mitochondrial DNA variation.

It takes a critical look at the field, flagging the problems, as well as the successes, and always placing the mitochondrial phylogeny centre stage.

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