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Alexander Disease: A Guide for Patients and Families, Albee Messing


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Автор: Albee Messing
Название:  Alexander Disease: A Guide for Patients and Families
ISBN: 9781615047642
Издательство: Mare Nostrum (Eurospan)
Классификация:



ISBN-10: 1615047646
Обложка/Формат: Hardback
Страницы: 96
Вес: 0.00 кг.
Дата издания: 30.11.2017
Серия: Colloquium series on neuroglia in biology and medicine: from physiology to disease
Язык: English
Размер: 229 x 152
Ключевые слова: Neurology & clinical neurophysiology,Pathology,Biology, life sciences,Life sciences: general issues, MEDICAL / Neurology,MEDICAL / Pathology,SCIENCE / Life Sciences / Biology
Подзаголовок: A guide for patients and families
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Поставляется из: Англии
Описание: This book offers a comprehensive overview of Alexander disease, a rare and devastating neurological disorder that often affects the white matter of the brain and spinal cord.Its distinctive neuropathology consists of abundant Rosenthal fibers within astrocytes (one of the four major cell types of the central nervous system). Nearly all cases are caused by variants in the gene encoding the intermediate filament protein GFAP, but how these changes in GFAP lead to the widespread manifestations of disease is poorly understood.Astrocytes, while discovered over a century ago, are themselves still much of a mystery. They exhibit considerable diversity, defy precise definition, and yet actively regulate many aspects of nervous system functioning.We also have incomplete understanding of Rosenthal fibers, odd structures that contain GFAP as just one of many components. Whether they are toxic or protective is unknown. Moreover, Rosenthal fibers are not absolutely unique to Alexander disease, and are seen sporadically in a wide variety of other conditions, including brain tumors and multiple sclerosis.GFAP is the third unknown. It is an ancient protein, arising early in the evolution of vertebrates, but its role in normal biology is still a matter of debate. Yet Alexander disease shows, without a doubt, that changing just a single of its 432 amino acids can lead to catastrophe, not just in the astrocytes where GFAP is produced but also in the other cells with which astrocytes interact.Despite all of the unknowns, much has been learned in the past 20 years, and it is time to share this knowledge. This book is intended for recently diagnosed patients and families, as well as non-specialist researchers interested in this neurological disease. It covers historical origins, the state of current knowledge, and prospects for what lies ahead, with citations to the primary literature given throughout.

Robbins and Cotran Pathologic Basis of Disease.-9 ed.

Автор: Abbas, Abul K. Fausto, Nelson Kumar, Vinay
Название: Robbins and Cotran Pathologic Basis of Disease.-9 ed.
ISBN: 0808924508 ISBN-13(EAN): 9780808924500
Издательство: Elsevier Science
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Цена: 60910.00 T
Наличие на складе: Поставка под заказ.
Описание: Ashton B. Carter said when announcing that the Pentagon would open all combat jobs to women, "I made a commitment to building America`s force of the future. In the twenty-first century, that requires drawing strength from the broadest possible pool of talent." William Taylor chronicles and analyses the long and ever-changing history of that often contentious and controversial effort.

Pathophysiology Of Disease: An Introduction To Clinical Medicine  7 IE

Автор: Hammer Gary D., McPhee Stephen J.
Название: Pathophysiology Of Disease: An Introduction To Clinical Medicine 7 IE
ISBN: 1259251446 ISBN-13(EAN): 9781259251443
Издательство: McGraw-Hill
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Цена: 64850.00 T
Наличие на складе: Поставка под заказ.
Описание: A complete case-based review of the essentials of pathophysiology - covering all major organs and systems

Pocket Companion to Robbins & Cotran Pathologic Basis of Disease, International edition: Elsevier Science, 2015.- ISBN:  9780323296403/Ричард Митчелл: Карманный справочник по патологии Робинса и Котрана

Автор: Mitchell, Richard N., M.D., Ph.D. Kumar, Vinay Fausto, Nelson Abbas, Abul K. Aster, Jon C.
Название: Pocket Companion to Robbins & Cotran Pathologic Basis of Disease, International edition: Elsevier Science, 2015.- ISBN: 9780323296403/Ричард Митчелл: Карманный справочник по патологии Робинса и Котрана
ISBN: 0323296408 ISBN-13(EAN): 9780323296403
Издательство: Elsevier Science
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Цена: 27500.00 T
Наличие на складе: Поставка под заказ.
Описание: Complemented by: Robbins and Cotran pathologic basis of disease / [edited by] Vinay Kumar, Abul K. Abbas, Jon C. Aster. Ninth edition. [2015].

Rating Scales in Parkinson`s Disease  Clinical Practice and Research

Автор: Cristina Sampaio, Christopher G. Goetz...
Название: Rating Scales in Parkinson`s Disease Clinical Practice and Research
ISBN: 0199783101 ISBN-13(EAN): 9780199783106
Издательство: Oxford Academ
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Цена: 81310.00 T
Наличие на складе: Есть
Описание: Parkinson Disease (PD) has been present. However the understanding of all intricacies of rating scales development was not widely available and the first attempts were relatively crude. In 2002, the Movement Disorders Society created a task force to systemize the measurement of Parkinson's Disease. Since then, the Task Force has produced and published several critiques to the available rating scales addressing both motor and non-motor domains of Parkinson Disease. Additionally the task force initiated a project to develop a new version of the UPDRS, the MDS-UPDRS. But none of this was made available in one convenient source. Until now. Rating Scales in Parkinson's Disease: Clinical Practice and Research is written for researchers from the medical and social sciences, and for health professionals wishing to evaluate the progress of their patients suffering from Parkinson's Disease. The book is both exhaustive in the description of the scales and informative on the advantages and limitations of each scale. As such, the text clearly guides readers on how to choose and use the instruments available. Extensive cross-referenced tables and charts closely integrate the parts of the book to facilitate readers in moving from one symptom domain to another. Features Based on a consistent and uniform methodology A clear consolidation of material otherwise only available in journals The first comprehensive book of its kind

Alzheimer`s Disease

Автор: Rudolph
Название: Alzheimer`s Disease
ISBN: 1439827087 ISBN-13(EAN): 9781439827086
Издательство: Taylor&Francis
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Цена: 114330.00 T
Наличие на складе: Есть
Описание:

In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer's disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer's Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD.

With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores:

  • The basis of AD and the role of Aβ oligomers in development of disease
  • Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies
  • In vivo imaging diagnostic approaches
  • Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies
  • Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emerging neuroprotective/neurorepair approaches
  • How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis
  • The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies
  • The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury

Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.


Robbins & Cotran Pathologic Basis of Disease, 9e

Автор: Kumar, Vinay Abbas, Abul K. Aster, Jon C.
Название: Robbins & Cotran Pathologic Basis of Disease, 9e
ISBN: 1455726133 ISBN-13(EAN): 9781455726134
Издательство: Elsevier Science
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Цена: 103150.00 T
Наличие на складе: Невозможна поставка.
Описание: "...perfect not only for thoroughly understanding the basis of pathology, but also for looking up specific conditions." (Medical Student Review) Dependable, current, and complete, Robbins and Cotran Pathologic Basis of Disease, 9th Edition is the perennially best-selling text that you'll use long after your medical student days are behind you. A world-class author team headed by Drs. Vinay Kumar, Abul Abbas, and Jon Aster, delivers the latest, most essential pathology knowledge in a readable, interesting manner, ensuring optimal understanding of the latest basic science and clinical content.

High-quality photographs and full-color illustrations highlight new information in molecular biology, disease classifications, new drugs and drug therapies, and much more. Rely on uniquely authoritative and readable coverage, ideal for USMLE or specialty board preparation, as well as for course work. Simplify your study with an outstanding full-color, highly user-friendly design.

Stay up to date with the latest information in molecular and genetic testing and mechanisms of disease. Consult new Targeted Therapy boxes online that discuss drug therapy for specific diseases. Gain a new perspective in key areas thanks to contributions from new authors at the top of their fields.

Student Consult eBook version included with purchase. Further your understanding with access to a wealth of interactive ancillaries on the Student Consult site, including pathology case studies and videos and self-assessment questions.


Nature`s machines

Автор: Alexander, David E. (department Of Ecology And Evo
Название: Nature`s machines
ISBN: 0128044047 ISBN-13(EAN): 9780128044049
Издательство: Elsevier Science
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Цена: 44860.00 T
Наличие на складе: Поставка под заказ.
Описание: Nature’s Machines: An Introduction to Organismal Biomechanics presents the fundamental principles of biomechanics in a concise, accessible way while maintaining necessary rigor. It covers the central principles of whole-organism biomechanics as they apply across the animal and plant kingdoms, featuring brief, tightly-focused coverage that does for biologists what H. M. Frost’s 1967 Introduction to Biomechanics did for physicians. Frequently encountered, basic concepts such as stress and strain, Young’s modulus, force coefficients, viscosity, and Reynolds number are introduced in early chapters in a self-contained format, making them quickly available for learning and as a refresher. . More sophisticated, integrative concepts such as viscoelasticity or properties of hydrostats are covered in the later chapters, where they draw on information from multiple earlier sections of the book. Animal and plant biomechanics is now a common research area widely acknowledged by organismal biologists to have broad relevance. Most of the day-to-day activities of an animal involve mechanical processes, and to the extent that organisms are shaped by adaptive evolution, many of those adaptations are constrained and channelized by mechanical properties. The similarity in body shape of a porpoise and a tuna is no coincidence. . Many may feel that they have an intuitive understanding of many of the mechanical processes that affect animals and plants, but careful biomechanical analyses often yield counterintuitive results: soft, squishy kelp may be better at withstanding pounding waves during storms than hard-shelled mollusks; really small swimmers might benefit from being spherical rather than streamlined; our bones can operate without breaking for decades, whereas steel surgical implants exhibit fatigue failures in a few months if not fully supported by bone.

Parkinson`s Disease and Other Movement Disorders

Автор: Edwards Mark
Название: Parkinson`s Disease and Other Movement Disorders
ISBN: 0198705069 ISBN-13(EAN): 9780198705062
Издательство: Oxford Academ
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Цена: 67590.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book allows the movement disorder clinician or therapist access to concise, practical, comprehensive and expert information on movement disorder diagnosis and treatment, in a convenient handbook form.

Diagnostic Atlas of Non-Neoplastic Lung Disease: A Practical Guide for Surgical Pathologists

Автор: Katzenstein Anna-Luise A.
Название: Diagnostic Atlas of Non-Neoplastic Lung Disease: A Practical Guide for Surgical Pathologists
ISBN: 1620700646 ISBN-13(EAN): 9781620700648
Издательство: Mare Nostrum (Eurospan)
Рейтинг:
Цена: 167190.00 T
Наличие на складе: Нет в наличии.
Описание: Provides the practicing pathologist with the tools necessary to synthesize diagnoses in biopsy and surgical specimens of non-neoplastic lung disease. In this heavily illustrated and concisely written book, Dr. Katzenstein has brought a pattern-based approach to formulating diagnoses in non-neoplastic lung diseases with the non-expert pulmonary pathologist in mind.

Clinical Neuropsychology and Cognitive Neurology of Parkinson`s Disease and Other Movement Disorders

Автор: Troster, Alexander I.
Название: Clinical Neuropsychology and Cognitive Neurology of Parkinson`s Disease and Other Movement Disorders
ISBN: 0199812373 ISBN-13(EAN): 9780199812370
Издательство: Oxford Academ
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Цена: 134640.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book describes the phenomenological features, assessment, and treatment of the wide variety of neurobehavioral conditions accompanying Parkinson`s disease and other movement disorders. Chapters from leading researchers in the field discuss general assessment strategies, quality of life, and neurophysiology and neuropathology relevant to neuropsychological features of movement disorders.

Understanding Your Migraines: A Guide for Patients and Families

Автор: Levin Morris, Ward Thomas N.
Название: Understanding Your Migraines: A Guide for Patients and Families
ISBN: 0190209151 ISBN-13(EAN): 9780190209155
Издательство: Oxford Academ
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Цена: 18470.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Understanding Your Migraines is a comprehensive and authoritative resource for people who suffer from migraine headaches, as well as for their families and their caretakers. Drs. Levin and Ward bring their vast experience studying and treating migraine to this book in a clear, practical and easily understandable volume which covers all of the aspects of migraine that plague individuals and their families. Numerous examples of real people with migraine helpillustrate the options available for finding relief for this highly disabling worldwide health problem.

The Lymphatic System in Health and Disease

Автор: J. Winny Yun, J. Steven Alexander
Название: The Lymphatic System in Health and Disease
ISBN: 1615047913 ISBN-13(EAN): 9781615047918
Издательство: Mare Nostrum (Eurospan)
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Цена: 37580.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The lymphatic system develops and functions in parallel with the blood circulatory system (termed the ""hemovasculature"") and accomplishes transport of interstitial fluids, dietary lipids, and reverse transport of cholesterol, immune cells, and antigens—providing a critical homeostatic fluid balance and transmission of immune cells and mediators back to the cardiovascular system. Although the daily flow of lymph (normally 1-2 L/day under unstressed conditions) is far lower than that of daily blood flow (which is 7,500 L/day), without the adequate functioning of the lymphatics, virtually all organs and tissues would acutely suffer many different physical and inflammatory stresses ranging from edema to organ system failure. Although blood and lymphatic vessels often form in anatomic parallels to one another, our knowledge of the workings of the lymphatic system, the fine structure of lymphatic networks, how they function in different organs, and how they are regulated physiologically and immunologically are far from parallel; our knowledge of the lymphatic system still remains at only a tiny fraction of what is understood about the cardiovascular system. Although both the cardiovascular and lymphatic systems are important transport systems, what they transport and how they transport and propel these very different cargoes could not be more dissimilar.This book provides an overview of the history of the discovery (and re-discovery) of the components of the lymphatic system, lymphatic anatomy, physiological functions of lymphatics, molecular features of the lymphatic system, and clinical perspectives involving lymphatics which may be of interest to scientists, clinicians, patients, and the lay public. We provide a current understanding of some of the more important structural similarities and differences between lymphatics and the blood vascular system, their coordinated control by angiogenic and hemangiogenic growth factors and other modulators, the fate and lineage determinants which control lymphatic development, and the roles that lymphatics may play in several different diseases.


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