Clinical Aspects of Interferons, Michel Revel

Автор: Paula M. Pitha
Название: Interferon: The 50th Anniversary
ISBN: 3642090443 ISBN-13(EAN): 9783642090448
Издательство: Springer
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Описание: A vital text for researchers and clinicians in the fields of virology and oncology alike, this book is a comprehensive guide to one of medicine`s most important tools that covers the most recent research. Important insights have been made in recent months that are challenging the accepted concept of the critical role of dsRNA in IFN induction.

Автор: Pitha Paula M.
Название: Interferon: / The 50th Anniversary
ISBN: 354071328X ISBN-13(EAN): 9783540713289
Издательство: Springer
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Цена: 204970.00 T
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Описание: Over the last half of century interferon (IFN), originally discovered as an antiviral protein, has developed from an inhibitor of viral replication to a major force in the antiviral response. Initially studied only by few virologists, IFN was generally considered as a poorly defined protein of limited importance. The development of molecular techniques lead to the identification of a family of IFN genes and has shown an unexpected complexity of type I IFN genes and their expression. Presently, some aspects of the of the pathogen mediated induction of IFN gene expression are understood at molecular level, while others are still at the stage of description. Both Toll like receptors and cytoplasmic RNA helicases were shown to recognize viral nucleic acids and the basis of a distinct recognition of viral nucleic acids from the cellular ones are emerging. Important insights on the virus recognition entity, leading to the expression of interferon and interferon induced genes, have been made in the recent year, which are challenging the accepted concept of the critical role of dsRNA in IFN induction. The availability of genetically modified mice that are lacking either essential components of the interferon inducing pathway, or interferon signaling pathway fully confirmed the original idea, made soon after its discovery, that interferon is the first cellular defense against viral infection.

Автор: Giovanni Gasbarrini; Stefano Pretolani
Название: Basic and Clinical Aspects of Helicobacter pylori Infection
ISBN: 3642782337 ISBN-13(EAN): 9783642782336
Издательство: Springer
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Цена: 102480.00 T
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Описание: Since 1982, when Helicobacter pylori was discovered, gastroduodenal disease have been completely revised as a con- sequence of the results of basic and clinical research in this field. The fourth Workshop of the European Helicobacter Pylori Study Group was held in Bologna, Italy, in November 1991.

Автор: Michel Revel
Название: Clinical Aspects of Interferons
ISBN: 1461289777 ISBN-13(EAN): 9781461289777
Издательство: Springer
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Автор: Yechiel Becker
Название: Antiviral Drugs and Interferon: The Molecular Basis of Their Activity
ISBN: 0898386438 ISBN-13(EAN): 9780898386431
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Цена: 231990.00 T
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Описание: Research on antiviral drugs and their mode of action in infected cells. Recent studies on antivirals that are activated by the herpes simplex virus type l-coded thy- midine kinase from a prod rug to an antiviral drug have opened new directions in the development of effective antiviral drugs.

Автор: Yechiel Becker
Название: Antiviral Drugs and Interferon: The Molecular Basis of Their Activity
ISBN: 1461338069 ISBN-13(EAN): 9781461338062
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Цена: 231990.00 T
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Описание: Research on antiviral drugs and their mode of action in infected cells. Recent studies on antivirals that are activated by the herpes simplex virus type l-coded thy- midine kinase from a prod rug to an antiviral drug have opened new directions in the development of effective antiviral drugs.

Автор: W. Stinebring
Название: Human Interferon
ISBN: 1461590825 ISBN-13(EAN): 9781461590828
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Цена: 46570.00 T
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Описание: This vo1ume sterns from a workshop held at the W. A1ton Jones Ce11 Science Center, Lake P1acid, New York, May 19-20, 1977. The Cen- ter is an operationa1 unit of the Tissue Cu1ture Association and offers, in co11aboration with the Association's Education Commit- tee, a wide range of activities. One of the ear1iest symposia held at the Center was one concerned with Interferon, (waymouth, C. (Ed. ) 1973. The Production and Use of Interferon for the Treat- ment and Prevention of Human Virus Infections. In Vitro, Mono- graph No. 3. Tissue Cu1ture Association, Rockvi11e, Mary1and. ) In the intervening years since that symposium, many deve10pments have taken p1ace. Much has been 1earned of the mo1ecu1ar bio1ogy of interferon. However, the focus of this particu1ar workshop, as the tit1e indicates, was the production of human interferon and investigation of its c1inica1 use. Evidence has accumu1ated that interferon is an effective antiviral and, possib1y, an anti tumor agent. The production of interferon requires human ce11s and proper inducing agents. Present produc- tion faci1ities are 1imited. The quantities of interferon needed for c1inica1 trials and eventual routine demand the deve10pment of new techniques in the growth and handling of ce11s and inducers. Safety is an important consideration in the production of bio1ogica1 products, and interferon is no exception. All components of the system and the final product must satisfy stringent safety standards.

Автор: Donald H. Gilden; Howard L. Lipton
Название: Clinical and Molecular Aspects of Neurotropic Virus Infection
ISBN: 1461289351 ISBN-13(EAN): 9781461289357
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Автор: Donald H. Gilden; Howard L. Lipton
Название: Clinical and Molecular Aspects of Neurotropic Virus Infection
ISBN: 0792300270 ISBN-13(EAN): 9780792300274
Издательство: Springer
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