Clinical Aspects of Interferons, Michel Revel

Автор: Pitha Paula M.
Название: Interferon: / The 50th Anniversary
ISBN: 354071328X ISBN-13(EAN): 9783540713289
Издательство: Springer
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Цена: 204970.00 T
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Описание: Over the last half of century interferon (IFN), originally discovered as an antiviral protein, has developed from an inhibitor of viral replication to a major force in the antiviral response. Initially studied only by few virologists, IFN was generally considered as a poorly defined protein of limited importance. The development of molecular techniques lead to the identification of a family of IFN genes and has shown an unexpected complexity of type I IFN genes and their expression. Presently, some aspects of the of the pathogen mediated induction of IFN gene expression are understood at molecular level, while others are still at the stage of description. Both Toll like receptors and cytoplasmic RNA helicases were shown to recognize viral nucleic acids and the basis of a distinct recognition of viral nucleic acids from the cellular ones are emerging. Important insights on the virus recognition entity, leading to the expression of interferon and interferon induced genes, have been made in the recent year, which are challenging the accepted concept of the critical role of dsRNA in IFN induction. The availability of genetically modified mice that are lacking either essential components of the interferon inducing pathway, or interferon signaling pathway fully confirmed the original idea, made soon after its discovery, that interferon is the first cellular defense against viral infection.

Автор: Michel Revel
Название: Clinical Aspects of Interferons
ISBN: 0898383714 ISBN-13(EAN): 9780898383713
Издательство: Springer
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Автор: Anthony Meager
Название: The Interferons: Characterization and Application
ISBN: 3527311807 ISBN-13(EAN): 9783527311804
Издательство: Wiley
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Цена: 153120.00 T
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Описание: At long last, the first book to cover all important areas of interferon science in one volume. Top scientists, including many pioneers in the field, highlight the role of interferons as research tools and as therapeutic agents in clinical applications. Edited by an experienced interferonologist, chapters include discussions of interferon genes, Type I, II and III IFNs, as well as their induction, production and purification, receptors actions, measuring IFN activities and anti-IFN antibodies, as well as the evolution of viral defense mechanisms. For immunologists, cancer researchers, medicinal chemists, cell biologists, developmental biologists and the pharmaceutical industry.

Автор: Dane Parker
Название: Bacterial Activation of Type I Interferons
ISBN: 331938502X ISBN-13(EAN): 9783319385020
Издательство: Springer
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Цена: 113180.00 T
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Описание: The type I interferon (IFN) signaling pathway is well recognized as a pathway activated by viral infections.

Автор: Carlo Aul; Wolfgang Schneider
Название: Interferons
ISBN: 3540610510 ISBN-13(EAN): 9783540610519
Издательство: Springer
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Цена: 102480.00 T
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Описание: Interferons were among the first cytokines to be studied clinically in recombinant form in the 1980s, beginning a new era of pharmacotherapy in internal medicine. This book contains a general introduction to the classification, structure and mode of action of interferons.

Автор: W.E.G. M?ller; H.C. Schr?der
Название: Biological Response Modifiers — Interferons, Double-Stranded RNA and 2?,5?-Oligoadenylates
ISBN: 3642785514 ISBN-13(EAN): 9783642785511
Издательство: Springer
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Цена: 121110.00 T
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Описание: Biological response modifiers are increasingly used in viral and cancer therapy. Since alterations of the immune system are the primary symptoms of HIV infection, especially therapies directed towards the modulation of the immune response have been under intense evaluation.

Автор: Karl Pummer
Название: Biological Modulation of Solid Tumours by Interferons
ISBN: 3642788688 ISBN-13(EAN): 9783642788680
Издательство: Springer
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Описание: For this purpose, after two chapters of general aspects of interferon action and interaction, selected solid tumours which are commonly considered difficult to treat in advanced stages are discussed with respect to both preclinical data and clinical experience.

Автор: Derek Crowther
Название: Interferons: Mechanisms of Action and Role in Cancer Therapy
ISBN: 3642767893 ISBN-13(EAN): 9783642767890
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Описание: A great deal of new information has been obtained during thepast four years, and this monograph provides a clear andwell reviewed update on biochemical mechanisms and theresults of important new clinical studies using theinterferons.

Автор: Daniel L. Kisner; J.F. Smyth
Название: Interferon Alpha-2: Pre-Clinical and Clinical Evaluation
ISBN: 0898387019 ISBN-13(EAN): 9780898387018
Издательство: Springer
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Цена: 153720.00 T
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Описание: Proceedings of the Symposium held in Adjunction with the Second International Conference on Malignant Lymphoma, Lugano, Switzerland, June 13, 1984

Автор: Daniel L. Kisner; J.F. Smyth
Название: Interferon Alpha-2: Pre-Clinical and Clinical Evaluation
ISBN: 1461296188 ISBN-13(EAN): 9781461296188
Издательство: Springer
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Цена: 121110.00 T
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Описание: Proceedings of the Symposium held in Adjunction with the Second International Conference on Malignant Lymphoma, Lugano, Switzerland, June 13, 1984

Автор: Paula M. Pitha
Название: Interferon: The 50th Anniversary
ISBN: 3642090443 ISBN-13(EAN): 9783642090448
Издательство: Springer
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Цена: 191550.00 T
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Описание: A vital text for researchers and clinicians in the fields of virology and oncology alike, this book is a comprehensive guide to one of medicine`s most important tools that covers the most recent research. Important insights have been made in recent months that are challenging the accepted concept of the critical role of dsRNA in IFN induction.

Автор: Carr Daniel J. J.
Название: Interferon Methods and Protocols
ISBN: 1588294188 ISBN-13(EAN): 9781588294180
Издательство: Springer
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Цена: 111790.00 T
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Описание: A compendium of methods to measure type I interferon efficacy as an antiproliferative or an antiviral agent. This book offers researchers tools not only to ascertain the functions of IFN-stimulatory gene products, but also to identify additional molecular pathways that will clarify our understanding of various biological events influenced by IFNs.