Pitha Paula M. Interferon: / The 50th Anniversary 9783540713289

Варианты приобретения

Цена: 204970.00T
Кол-во:
о цене
Наличие: Невозможна поставка.

в Мои желания

Автор: Pitha Paula M.
Название: Interferon: / The 50th Anniversary
ISBN: 9783540713289
Издательство: Springer
Классификация:

Иммунология

Медицинская микробиология и вирусология

ISBN-10: 354071328X
Обложка/Формат: Hardback
Страницы: 400
Вес: 0.77 кг.
Дата издания: 11.09.2007
Серия: Current Topics in Microbiology and Immunology
Язык: English
Иллюстрации: 8 tables, black and white; 22 illustrations, color; 13 illustrations, black and white; viii, 392 p. 35 illus., 22 illus. in color.
Размер: 23.95 x 16.31 x 1.96 cm
Читательская аудитория: Postgraduate, research & scholarly
Подзаголовок: The 50th anniversary
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Германии
Описание: Over the last half of century interferon (IFN), originally discovered as an antiviral protein, has developed from an inhibitor of viral replication to a major force in the antiviral response. Initially studied only by few virologists, IFN was generally considered as a poorly defined protein of limited importance. The development of molecular techniques lead to the identification of a family of IFN genes and has shown an unexpected complexity of type I IFN genes and their expression. Presently, some aspects of the of the pathogen mediated induction of IFN gene expression are understood at molecular level, while others are still at the stage of description. Both Toll like receptors and cytoplasmic RNA helicases were shown to recognize viral nucleic acids and the basis of a distinct recognition of viral nucleic acids from the cellular ones are emerging. Important insights on the virus recognition entity, leading to the expression of interferon and interferon induced genes, have been made in the recent year, which are challenging the accepted concept of the critical role of dsRNA in IFN induction. The availability of genetically modified mice that are lacking either essential components of the interferon inducing pathway, or interferon signaling pathway fully confirmed the original idea, made soon after its discovery, that interferon is the first cellular defense against viral infection.
Дополнительное описание: Refletions.- How to Chase a Red Herring and Come up with a Smallmouth Bass.- Interferon Research BC (Before Cloning).- Purification and Cloning of Interferon Alpha.- Interferons and Their Signaling Pathways.- Type I Interferon: The Ever Unfolding Story.-

Interferon: / The 50th Anniversary, Pitha Paula M.