Modeling Inhibitors of Matrix Metalloproteinases, Tarun Jha

Автор: Ian M. Clark
Название: Matrix Metalloproteinase Protocols
ISBN: 1603272984 ISBN-13(EAN): 9781603272988
Издательство: Springer
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Цена: 97820.00 T
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Описание: Detailing proven laboratory techniques for the study of MMPs, this book covers the methods including those for the expression and purification of MMPs and TIMPs, for the detection of MMPs and TIMPs at both the protein and mRNA levels, and for the assay of MMP and TIMP activities in a variety of circumstances.

Автор: Clark Ian M.
Название: Matrix Metalloproteinase Protocols
ISBN: 1493956221 ISBN-13(EAN): 9781493956227
Издательство: Springer
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Цена: 139750.00 T
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Описание: Since the discovery of a collagen-degrading protease in the tadpole tail in 1962, matrix metalloproteinase research has led to the discovery of more than twenty distinct vertebrate MMPs, along with a variety of homologues from diverse organisms such as the sea urchin, plants, insects, and nematode worms. Fully updating and adding to the popular first edition, Matrix Metalloproteinase Protocols, Second Edition includes a series of state-of-the-art techniques provided by eminent experts in the field. Beginning with a brief overview of the MMP arena, from how these enzymes fit into the larger degradome to what occurs when their expression and function in the mouse is modulated, the volume continues with sections on the expression and purification of MMPs and TIMPs, the detection of MMPs and TIMPs at both the protein and mRNA level, and our ability to assay MMP and TIMP activities in a wide variety of circumstances. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Matrix Metalloproteinase Protocols, Second Edition is an ideal source for many of the essential laboratory techniques for both novice and seasoned researchers alike collected in one convenient volume.

Автор: Curtin Nicola J., Sharma Ricky A.
Название: Parp Inhibitors for Cancer Therapy
ISBN: 3319344897 ISBN-13(EAN): 9783319344898
Издательство: Springer
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Цена: 139750.00 T
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Описание: PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible chemistry behind the development of inhibitors. PARP inhibitors are a group of pharmacological inhibitors that are a particularly good target for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer. Researchers have learned a tremendous amount about the biology of PARP and how tumour-specific defects in DNA repair can be exploited by PARPi. The “synthetic lethality” of PARPi is an exciting concept for cancer therapy and has led to a heightened activity in this area.

Автор: Ingo K. Mellinghoff; Charles L. Sawyers
Название: Therapeutic Kinase Inhibitors
ISBN: 3642445802 ISBN-13(EAN): 9783642445804
Издательство: Springer
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Цена: 174130.00 T
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Cancer drug development is currently undergoing a profound shift. Drugs targeting fundamental cellular processes such DNA-replication and microtubule function, often referred to as chemotherapy and still the backbone of most cancer treatment regimens, are increasingly being complemented by or replaced with kinase inhibitors. This new class of drugs targets enzymes which provide growth and survival signals to cancer cells by transferring phosphate groups from Adenosine-5'-triphosphate (ATP) to other proteins, lipids, nucleotides, and carbohydrates.

This book summarizes the current state of kinase inhibitor therapy for cancer. Successful drug development relies on the expertise and dedication of many experts. To reflect this team approach to finding new kinase inhibitors and defining their optimal use for cancer treatment, the editorsinvited experts in academia and pharmaceutical industry to share their insights into various aspects of this process, ranging from the first chemical screens, to preclinical testing and disease-focused clinical drug development. The editors and authorshope these lessons will be instructive for the novice as well as the expert. "

Автор: Ganai, Shabir Ahmad
Название: Natural hdac inhibitors for epigenetic combating of cancer progression
ISBN: 1032279869 ISBN-13(EAN): 9781032279862
Издательство: Taylor&Francis
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Цена: 94930.00 T
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Описание: This Book entitled "Natural HDAC Inhibitors for Epigenetic Combating of Cancer Progression" deals only with HDAC inhibitors from natural origin including bacteria, fungi, marine organisms and notably from diverse plant sources.

Автор: Vitaly A. Polunovsky; Peter J. Houghton
Название: mTOR Pathway and mTOR Inhibitors in Cancer Therapy
ISBN: 1617796948 ISBN-13(EAN): 9781617796944
Издательство: Springer
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Цена: 191550.00 T
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Описание: The target of rapamycin (TOR) was rst identi ed in Saccharomyces cerevisiae and subsequently in mammals (mTOR) as a conserved atypical serine/threonine kinase. Rapamycin was isolated as a product of the soil bacteria Streptomyces hygroscopicus, identi ed in a soil sample taken from the island of Rapa Nui (Easter Island).

Автор: Martin Lorenz Stein
Название: NMR-Bioassay Guided Isolation of the Natural 20S Proteasome Inhibitors from Photorhabdus Luminescens
ISBN: 3319079131 ISBN-13(EAN): 9783319079134
Издательство: Springer
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Цена: 93160.00 T
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Описание: Martin Stein's thesis describes a novel methodology for natural product discovery. Due to its high degree of reproducibility, robustness and sensitivity, the technique can be utilized to detect even trace amounts of bioactive substances in heterogeneous matrices such as fermentation broths or crude organic extracts. This research is thus relevant for a large number of researchers working in natural product discovery. Applications of this novel NMR-based approach include suitable environmental triggers for the induction of biosynthetic machineries. The author demonstrates the extraordinary value of this approach by the successful isolation of two potent inhibitors of the pharmaceutically relevant proteasome core particle from the insect pathogen photorhabdus luminescens. This thesis has led to a number of publications in high-impact journals.

Автор: Robert B. Sim
Название: Activators and Inhibitors of Complement
ISBN: 9401052247 ISBN-13(EAN): 9789401052245
Издательство: Springer
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Цена: 191560.00 T
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Автор: Maheshwari
Название: Natural Products as Enzyme Inhibitors
ISBN: 9811909318 ISBN-13(EAN): 9789811909313
Издательство: Springer
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Цена: 139750.00 T
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Описание: Chapters in this book cover topics such as plant-derived inhibitors of serine proteases, pancreatic lipase (PL) inhibitors from indigenous medicinal plants, amylase inhibitors and their applications in agriculture and food processing industries and advances in silico techniques used in the study of enzyme inhibitors.

Автор: Ward Richard A., Grimster Neil
Название: The Design of Covalent-Based Inhibitors
ISBN: 0128216891 ISBN-13(EAN): 9780128216897
Издательство: Elsevier Science
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Цена: 154960.00 T
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Annual Report on Medicinal Chemistry series, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Название: Viral Replication Enzymes and Their Inhibitors Part B, 50
ISBN: 032390016X ISBN-13(EAN): 9780323900164
Издательство: Elsevier Science
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Цена: 140360.00 T
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Описание: Viral Replication Enzymes and their Inhibitors, Part B, Volume 50 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics surrounding enzymes.

Название: Viral Replication Enzymes and Their Inhibitors Part A, 49
ISBN: 0128234687 ISBN-13(EAN): 9780128234686
Издательство: Elsevier Science
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Цена: 140360.00 T
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Описание: Viral Replication Enzymes and their Inhibitors Part A, Volume 49, the latest release in the Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of related topics