Drug Delivery Strategies for Poorly Water-Soluble Drugs, Douroumis
Автор: Hauss, David J. Название: Oral Lipid-Based Formulations ISBN: 0824729455 ISBN-13(EAN): 9780824729455 Издательство: Taylor&Francis Рейтинг: Цена: 183750.00 T Наличие на складе: Нет в наличии.
Автор: Misra Название: Novel Drug Delivery Technologies ISBN: 9811336415 ISBN-13(EAN): 9789811336416 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: By endowing drugs with new and innovative therapeutic benefits, drug delivery systems extend products` profitable lifecycle, giving pharmaceutical companies competitive and financial advantages, and providing patients with improved medications.
Автор: Chellappan Dinesh Kumar, Pabreja Kavita, Faiyazuddin MD Название: Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases ISBN: 9811643911 ISBN-13(EAN): 9789811643910 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book describes the growing clinical and healthcare relevance of nano-therapeutics in treating respiratory diseases. It further discusses the current trends in understanding the disease pathology using different in vitro and in vivo models, which are important towards the onsite clinical applications and development of new therapeutics.
Автор: Williams III Название: Formulating Poorly Water Soluble Drugs ISBN: 3030887189 ISBN-13(EAN): 9783030887186 Издательство: Springer Рейтинг: Цена: 214280.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The objective of this third edition is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop.
Автор: Williams III Название: Formulating Poorly Water Soluble Drugs ISBN: 3030887219 ISBN-13(EAN): 9783030887216 Издательство: Springer Рейтинг: Цена: 214280.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The objective of this third edition is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop.
Автор: Robert O. Williams III; Alan B. Watts; Dave A. Mil Название: Formulating Poorly Water Soluble Drugs ISBN: 3319826182 ISBN-13(EAN): 9783319826189 Издательство: Springer Рейтинг: Цена: 153720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The objective of this volume is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules.
Автор: Robert O. Williams III; Alan B. Watts; Dave A. Mil Название: Formulating Poorly Water Soluble Drugs ISBN: 1489985921 ISBN-13(EAN): 9781489985927 Издательство: Springer Рейтинг: Цена: 217670.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book highlights recent advancements on technologies to improve the dissolution and bioavailability of poorly water soluble drugs. It details the most current knowledge, practical methods, and regulatory considerations.
Автор: Webster Название: Poorly Soluble Drugs ISBN: 9814745456 ISBN-13(EAN): 9789814745451 Издательство: Taylor&Francis Рейтинг: Цена: 209270.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis- -vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development.
Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.
Автор: Lino Messana Название: Poorly Soluble Drugs ISBN: 1681177013 ISBN-13(EAN): 9781681177014 Издательство: Gazelle Book Services Рейтинг: Цена: 217350.00 T Наличие на складе: Невозможна поставка. Описание: Solubility is the property of a solid, liquid, or gaseous chemical substance called solute to dissolve in a solid, liquid, or gaseous solvent to form a homogeneous solution of the solute in the solvent. The solubility of a substance fundamentally depends on the solvent used as well as on temperature and pressure. The extent of solubility of a substance in a specific solvent is measured as the saturation concentration where adding more solute does not increase its concentration in the solution. Solubility also plays a major role for other dosage forms like parenteral formulations as well. Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. Consequently, the development of techniques and materials to overcome these hurdles is a major area of research in pharmaceutical companies. This book provides a comprehensive overview of currently used formulation strategies for hydrophobic drugs discusses the main instrumentation, operation principles and theoretical background, with a focus on critical formulation features and clinical studies. It provides a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Over 40% of new chemical entities developed in pharmaceutical industry are practically insoluble in water. These poorly water soluble drugs having slow drug absorption leads to inadequate and variable bioavailability and gastrointestinal mucosal toxicity. For orally administered drugs solubility is the most important one rate limiting parameter to achieve their desired concentration in systemic circulation for pharmacological response. Problem of solubility is a major challenge for formulation scientist. The improvement of drug solubility thereby its oral bioavailability remains one of the most challenging aspects of drug development process especially for oral-drug delivery system.
Автор: Andreas Bernkop-Schn?rch Название: Oral Delivery of Macromolecular Drugs ISBN: 1489982825 ISBN-13(EAN): 9781489982827 Издательство: Springer Рейтинг: Цена: 174130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book provides an overview of the innovative oral delivery technologies that have demonstrated success in human testing. It then goes on to cite the challenges, strategies, and future trends that are to be expected.
Автор: Gregory Gregoriadis; Brenda McCormack Название: Targeting of Drugs 5 ISBN: 0306455048 ISBN-13(EAN): 9780306455049 Издательство: Springer Рейтинг: Цена: 74490.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of a NATO ASI held in Cape Sounion, Greece, June 24-July 5, 1995
Автор: Focarete, Maria Название: Core-Shell Nanostructures for Drug Delivery and Theranostics ISBN: 0081021984 ISBN-13(EAN): 9780081021989 Издательство: Elsevier Science Рейтинг: Цена: 230190.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Core-shell nanostructures for drug delivery and theranostics brings together cutting-edge research to provide detailed coverage of core-shell nanoparticles and nanofibers for drug delivery, enabling scientists and researchers to understand the latest advances and applications in this field.
The development of polymeric drug delivery systems and technologies continues to present new possibilities in terms of controlled drug release and drug targeting capabilities. Core-shell nanostructures offer many benefits, such as temporal-spatial controlled release, drug/biomolecule protection from harsh environments, and multi-drug release, and may therefore be utilized in advanced and challenging applications.
The opening part of the book deals with the fundamentals of nanotechnology for drug delivery. The second part of the book covers the recent developments and research in core-shell nanoparticles for drug-delivery and theranostic applications. The third part addresses the potential and applications of core-shell nanofiber.
This book is a highly valuable resource for scientists interested in the design and development of innovative drug delivery systems, researchers and graduate/postdoctoral students engaged in biomaterials for drug delivery, and R&D managers in the biomaterials and pharmaceutical industry.
Focuses on core-shell nanoparticles and nanofiber for innovative applications, including cancer therapy, controlled release and multi-drug release
Considers future prospects and potential new applications of core-shell nanostructures for drug delivery and theranostics
Explains the principles and essential concepts of nanotechnology for drug delivery systems
Казахстан, 010000 г. Астана, проспект Туран 43/5, НП2 (офис 2) ТОО "Логобук" Тел:+7 707 857-29-98 ,+7(7172) 65-23-70 www.logobook.kz
