Formulating Poorly Water Soluble Drugs, Robert O. Williams III; Alan B. Watts; Dave A. Mil

Автор: Webster
Название: Poorly Soluble Drugs
ISBN: 9814745456 ISBN-13(EAN): 9789814745451
Издательство: Taylor&Francis
Рейтинг:
Цена: 209270.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:

This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis- -vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development.

Автор: Robert O. Williams III; Alan B. Watts; Dave A. Mil
Название: Formulating Poorly Water Soluble Drugs
ISBN: 1489985921 ISBN-13(EAN): 9781489985927
Издательство: Springer
Рейтинг:
Цена: 217670.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book highlights recent advancements on technologies to improve the dissolution and bioavailability of poorly water soluble drugs. It details the most current knowledge, practical methods, and regulatory considerations.

Автор: Lino Messana
Название: Poorly Soluble Drugs
ISBN: 1681177013 ISBN-13(EAN): 9781681177014
Издательство: Gazelle Book Services
Рейтинг:
Цена: 217350.00 T
Наличие на складе: Невозможна поставка.
Описание: Solubility is the property of a solid, liquid, or gaseous chemical substance called solute to dissolve in a solid, liquid, or gaseous solvent to form a homogeneous solution of the solute in the solvent. The solubility of a substance fundamentally depends on the solvent used as well as on temperature and pressure. The extent of solubility of a substance in a specific solvent is measured as the saturation concentration where adding more solute does not increase its concentration in the solution. Solubility also plays a major role for other dosage forms like parenteral formulations as well. Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. Consequently, the development of techniques and materials to overcome these hurdles is a major area of research in pharmaceutical companies. This book provides a comprehensive overview of currently used formulation strategies for hydrophobic drugs discusses the main instrumentation, operation principles and theoretical background, with a focus on critical formulation features and clinical studies. It provides a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Over 40% of new chemical entities developed in pharmaceutical industry are practically insoluble in water. These poorly water soluble drugs having slow drug absorption leads to inadequate and variable bioavailability and gastrointestinal mucosal toxicity. For orally administered drugs solubility is the most important one rate limiting parameter to achieve their desired concentration in systemic circulation for pharmacological response. Problem of solubility is a major challenge for formulation scientist. The improvement of drug solubility thereby its oral bioavailability remains one of the most challenging aspects of drug development process especially for oral-drug delivery system.

Автор: Puccetti Germain, Barnes Caren M.
Название: Art and Science of Formulating Cosmetic Products
ISBN: 0820601993 ISBN-13(EAN): 9780820601991
Издательство: Mare Nostrum (Eurospan)
Рейтинг:
Цена: 127510.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The new 9th edition of Harry's Cosmeticology is available as a three-volume set containing over 2,600 pages of new information on the recent changes in the cosmetic and personal care industry. Chemical Publishing is now offering key parts of the title for those interested in a particular subject area covered in the book with a new line of ‘Focus Books’ for this purpose. Each Focus Book contains a series of selected chapters that can be used as a reference guide for a particular subject area. This focus book covers Part 6: The Art and Science of Formulating Cosmetics Products.

Автор: Wilfried R?hse
Название: Cosmetic Creams: Development and Formulation of Effective Skin Care Products
ISBN: 3527343989 ISBN-13(EAN): 9783527343980
Издательство: Wiley
Рейтинг:
Цена: 147790.00 T
Наличие на складе: Поставка под заказ.
Описание: A guide to cosmetic creams that focuses on formulation, production, and safety concerns

Cosmetic Creams: Development, Manufacture and Marketing of Effective Skin Care Products puts the focus on the structure and formulation of a cosmetic cream, the production process, the effect of each ingredient, as well as safety considerations. Comprehensive in scope, the book contains a basic definition of cosmetics and describes the types of skin creams currently on the market, the major ingredients used, and example compositions. The author, Wilfried R?hse?a noted expert on the topic?offers guidelines for estimating manufacturing costs and includes procedures for an effective safety assessment.

The book contains information on various aspects of skin penetration and production and covers issues like materials used and hygienic packaging. In addition, R?hse reviews legal regulations with an emphasis on the European market. He discusses GMP and EHEDG directives. This important book:

-Offers a comprehensive resource that explores all aspects of cosmetic cream manufacturing and marketing
-Provides valuable guidelines for practitioners in the field
-Covers the underlying technologies of cosmetic creams
-Includes a review of raw material and manufacturing costs, hygiene and safety, and legal regulations
-Written by an author with more than 30 years? experience in the industry

Written for cosmetic chemists, chemists in industry, chemical engineers, dermatologists, Cosmetic Creams: Development, Manufacture and Marketing of Effective Skin Care Products, offers a unique industrial perspective of the topic that is comprehensive in scope.

Автор: Zeng, Xian Ming Martin, Gary Peter Marriott, Christopher
Название: Particulate interactions in dry powder formulation for inhalation
ISBN: 0367397978 ISBN-13(EAN): 9780367397975
Издательство: Taylor&Francis
Рейтинг:
Цена: 65320.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Pharmaceutical Isothermal Calorimetry discusses the application of isothermal calorimetric techniques to challenges encountered during the rational design and development of novel drugs and drug delivery systems. Providing a comprehensive review of recent research and trends, this book contains an expert discussion of research and applications to pharmaceutical characterization and formulation.

Название: Water Insoluble Drug Formulation, 3
ISBN: 149872941X ISBN-13(EAN): 9781498729413
Издательство: Taylor&Francis
Рейтинг:
Цена: 265410.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Water-Insoluble Drug Formulation, Third Edition serves as a comprehensive reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs.