High-throughput mass spectrometry in drug discovery,
Название: High-Throughput Analysis in the Pharmaceutical Industry ISBN: 036738700X ISBN-13(EAN): 9780367387006 Издательство: Taylor&Francis Рейтинг: Цена: 65320.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The ever-shortening timelines and the high costs of drug discovery and development have brought about the need for high throughput approaches to methods that are currently used in the pharmaceutical industry. Written by well-known contributors, this book systematically describes high-throughput analysis for the industry. Exploring advanced instrumentation and automated sample preparation, the text discusses various techniques, including HPLC, MALDI-MS, and LC-MS/MS methods. An emphasis is placed on the later stage of drug development and the book includes discussions of topics such as pharmacokinetics.
The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery integrates the experience of diverse experts who offer fundamental and practical guidance across numerous situations.
The book first discusses assay developments for important target classes such as protein kinases and phosphatases, proteases, nuclear receptors, G protein-coupled receptors, ion channels, and heat shock proteins. It next examines assay developments for cell viability, apoptosis, and infectious diseases. The contributors explore the application of emerging technologies and systems, including image-based high content screening, RNA interference, and primary cells. Finally, they discuss the essential components of the integrated HTS process, such as screening automation, compound library management, the screening of natural products from botanical sources, and screening informatics.
Designed to motivate researchers to bring further advances to the field, this volume provides practical guidance on how to initiate, validate, optimize, and manage a bioassay intended to screen large collections of compounds. Drawing on the knowledge from experts actively involved in assay development and HTS, this is a resource that is both comprehensive and focused.
Автор: Kisaalita, William S. Название: 3D Cell-Based Biosensors in Drug Discovery Programs ISBN: 1420073494 ISBN-13(EAN): 9781420073492 Издательство: Taylor&Francis Рейтинг: Цена: 209270.00 T Наличие на складе: Нет в наличии.
Автор: Wang, Perry G. Название: High-Throughput Analysis in the Pharmaceutical Industry ISBN: 142005953X ISBN-13(EAN): 9781420059533 Издательство: Taylor&Francis Рейтинг: Цена: 224570.00 T Наличие на складе: Нет в наличии.
Автор: Rossi, David T. Название: Mass Spectrometry in Drug Discovery ISBN: 0824706072 ISBN-13(EAN): 9780824706074 Издательство: Taylor&Francis Рейтинг: Цена: 224570.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Korfmacher Название: Mass Spectrometry for Drug Discovery and Drug Deve lopment ISBN: 047094238X ISBN-13(EAN): 9780470942383 Издательство: Wiley Рейтинг: Цена: 120330.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Название: Using Mass Spectrometry for Drug Metabolism Studies ISBN: 0367384957 ISBN-13(EAN): 9780367384951 Издательство: Taylor&Francis Рейтинг: Цена: 65320.00 T Наличие на складе: Нет в наличии. Описание:
The first edition of this now classic work helped to establish mass spectrometry as the premier tool for drug metabolism studies. Completely rewritten from start to finish, Using Mass Spectrometry for Drug Metabolism Studies, Second Edition brings medicinal chemists and mass spectrometry professionals up to speed with the rapid advances in the field, the emergence of cutting-edge approaches, and ways to meet steadily increasing vendor demands. Written by international scientists who are experts in their respective disciplines, this state-of-the-art reference effectively encapsulates current mass spectrometry best practices.
The stand-alone chapters cover various topics - from metabolite identification to fast chromatography with UPLC - and in a style that is understandable to experts and field newcomers alike. The second edition of this bestseller includes coverage of new instrumentation and software as well as a wealth of updated information on the latest findings surrounding biomarkers and metabolomics and new chapters on both UPLC and DESI/DART.
With more than 180 illustrations and an eight-page color insert, this valuable reference explores multiple modern mass spectrometry techniques and strategies. It includes an excellent overview of the entire drug discovery process plus the latest developments on how mass spectrometry is used to support this endeavor.
Автор: Korfmacher, Walter A. Название: Using Mass Spectrometry for Drug Metabolism Studies ISBN: 1420092200 ISBN-13(EAN): 9781420092202 Издательство: Taylor&Francis Рейтинг: Цена: 224570.00 T Наличие на складе: Нет в наличии.
Автор: Gopi, Sreeraj Название: High-Resolution Mass Spectrometry and Its Diverse Applications ISBN: 1774911124 ISBN-13(EAN): 9781774911129 Издательство: Taylor&Francis Рейтинг: Цена: 133730.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Название: High-Throughput Lead Optimization in Drug Discovery ISBN: 0367387719 ISBN-13(EAN): 9780367387716 Издательство: Taylor&Francis Рейтинг: Цена: 65320.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
A Single Source on Parallel Synthesis for Lead Optimization
The end of the previous millennium saw an explosion in the application of parallel synthesis techniques for making compounds for high-throughput screening. Over time, it became clear that more thought in the design phase of library development is necessary to generate high quality hits. More recently, the use of parallel synthesis techniques has shifted to applications beyond screening collections. Exploring the nuances of this technology, High-Throughput Lead Optimization in Drug Discovery describes the application of parallel synthesis to lead optimization and the design and synthesis of targeted libraries.
Examine Case Studies that Cover a Range of Different Biological Targets
Featuring real-world examples and contributions from well-known scientists, the book explores the shift to conducting parallel lead optimization in-house while outsourcing most of the screening libraries synthesis. It includes more than 15 case studies that encompass a range of biological targets for application in different therapeutic areas. The text contains examples of solid and solution-phase techniques for the synthesis of directed libraries. The chapter authors explain the design principles they used to direct the choice of templates and diversity elements.
Speed Up Drug Discovery and the Hit-to-Lead Process
Focusing on the application of combinatorial chemistry to medicinal chemistry, this volume compiles a series of optimization projects that give you a snapshot of successes and challenges in the use of parallel synthesis for lead optimization. It explores how this technology, when applied to library design, can speed up drug discovery.
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