Using Mass Spectrometry for Drug Metabolism Studies,
Автор: Huibin Wei Название: Studying Cell Metabolism and Cell Interactions Using Microfluidic Devices Coupled with Mass Spectrometry ISBN: 3642430864 ISBN-13(EAN): 9783642430862 Издательство: Springer Рейтинг: Цена: 87060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book describes a new approach for cell analysis by the rapid developing microfluidic technology. It develops a new analysis platform which combined microfluidic devices with mass spectrometry to determine the trace compounds secreted by cells.
Автор: Frigerio Название: Mass Spectrometry in Drug Metabolism ISBN: 1461341531 ISBN-13(EAN): 9781461341536 Издательство: Springer Рейтинг: Цена: 81050.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: When a dose of drug is administered, three main phases of drug action may be distingushed.
Автор: John Greaves Название: Mass Spectrometry for the Novice ISBN: 1420094181 ISBN-13(EAN): 9781420094183 Издательство: Taylor&Francis Рейтинг: Цена: 80630.00 T Наличие на складе: Нет в наличии. Описание:
With usage of mass spectrometry continually expanding, an increasing number of scientists, technicians, students, and physicians are coming into contact with this valuable technique. Mass spectrometry has many uses, both qualitative and quantitative, from analyzing simple gases to environmental contaminants, pharmaceuticals, and complex biopolymers. The extraordinary versatility can make mass spectrometers daunting to novices. Consequently, new users would benefit greatly from an understanding of the basic concepts as well as the processes that occur in these instruments. Mass Spectrometry for the Novice provides exactly that, with detailed, straightforward descriptions and clear illustrations of principles of operations and techniques.
The book begins with an overview that includes essential definitions and then provides information on the components of and the strategies used in the most common instruments. The authors discuss the methodologies available, classes of compounds analyzed, and the types of data that can be generated. A group of representative applications from published articles is summarized, demonstrating the diversity of mass spectrometry. The authors also condense the essentials of the topic into one invaluable chapter that provides a set of concise take-home messages on all aspects of mass spectrometry. The final section provides a collection of resources including books, reviews, and useful websites. Using simple language, new color figures, clever cartoons, and assuming no prior knowledge, this book provides a readily understandable entr e to mass spectrometry. A CD-ROM with selected figures and cartoons is included.
Автор: Vladimir A. Krasnopolsky Название: Spectroscopy and Photochemistry of Planetary Atmospheres and Ionospheres: Mars, Venus, Titan, Triton and Pluto ISBN: 1107145260 ISBN-13(EAN): 9781107145269 Издательство: Cambridge Academ Рейтинг: Цена: 83430.00 T Наличие на складе: Поставка под заказ. Описание: This book provides a detailed overview of the fundamental principles and methods of spectroscopy and photochemical modeling for studying the chemical composition of planetary atmospheres and ionospheres. With detailed reviews of Mars, Venus, Titan, Triton and Pluto, it is a valuable reference for graduate students, researchers and planetary scientists.
Название: Characterization of protein therapeutics using mass spectrometry ISBN: 1489973648 ISBN-13(EAN): 9781489973641 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book highlights current approaches and future trends in the use of mass spectrometry to characterize protein therapies. As one of the most frequently utilized analytical techniques in pharmaceutical research and development, mass spectrometry has been widely used in the characterization of protein therapeutics due to its analytical sensitivity, selectivity, and specificity. This book begins with an overview of mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies, quantitative approaches, followed by studies involving characterization of process related protein drug impurities/degradants, metabolites, higher order structures of protein therapeutics. Both general practitioners in pharmaceutical research and specialists in analytical sciences will benefit from this book that details step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development.
Автор: Matthew Jenner Название: Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases ISBN: 3319327224 ISBN-13(EAN): 9783319327228 Издательство: Springer Рейтинг: Цена: 95770.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Introduction.- Materials and Methods.- Substrate Specificity of Ketosynthase Domains Part I: β-Branched Acyl Chains.- Substrate Specificity of Ketosynthase Domains Part II: Amino Acid-Containing Acyl Chains.- Synthesis of Acyl-Acyl Carrier Proteins and their use in Studying Polyketide Synthase Enzymology.- Substrate Specificity of Ketosynthase Domains Part III: Elongation-Based Substrate Specificity.
Автор: Gui-Juan Cheng Название: Mechanistic Studies on Transition Metal-Catalyzed C–H Activation Reactions Using Combined Mass Spectrometry and Theoretical Methods ISBN: 9811045208 ISBN-13(EAN): 9789811045202 Издательство: Springer Рейтинг: Цена: 102480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The reactions investigated include: (i) a nitrile-containing template-assisted meta-selective C-H activation, (ii) Pd/mono-N-protected amino acid (MPAA) catalyzed meta-selective C-H activation, (iii) Pd/MPAA catalyzed asymmetric C-H activation reactions, and (iv) Cu-catalyzed sp3 C-H cross-dehydrogenative-coupling reaction.
Автор: Jenner Matthew Название: Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases ISBN: 3319813552 ISBN-13(EAN): 9783319813554 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This thesis reports studies on the substrate specificity of crucial ketosynthase (KS) domains from trans-AT Polyketide Synthases (PKSs). Using a combination of electrospray ionisation-mass spectrometry (ESI-MS) and simple N-acetyl cysteamine (SNAC) substrate mimics, the specificity of a range of KS domains from the bacillaene and psymberin PKSs have been succsessfully studied with regard to the initial acylation step of KS-catalysis. In addition, the ability to alter the substrate tolerance of KS domains by simple point mutations in the active site has been demonstrated. A series of acyl-ACPs have been synthesised using a novel methodology and employed to probe the substrate specificity of both KS domains and the previously uncharcterised acyl hydrolase domain, PedC. KS-catalysed chain elongation reactions have also been conducted and monitored by ESI-MS/MS. All KS domains studied exhibited higher substrate specificity at the elongation step than in the preceeding acylation step. Furthermore, a mechanism of reversible acylation is proposed using the PsyA ACP1-KS1 di-domain. The findings in this thesis provide important insights into mechanisms of KS specificity and show that mutagenesis can be used to expand the repertoire of acceptable substrates for future PKS engineering.
Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development
Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery
Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs, instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis
Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives
Brings together the most current advances in the mass spectrometry technology and related method in protein analysis
Автор: Bolgar Mark S. Название: Mass Spectrometry in Biopharmaceutical and Emerging Drug Modalities ISBN: 1782629750 ISBN-13(EAN): 9781782629757 Издательство: Royal Society of Chemistry Рейтинг: Цена: 223870.00 T Наличие на складе: Невозможна поставка. Описание: The focus of this book is on the use of mass spectrometry (MS) for the assessment of alternative modes of drug efficacy and inclusion of information on the use of MS in the development of protein biosimilars.
Автор: Cheng Gui-Juan Название: Mechanistic Studies on Transition Metal-Catalyzed C-H Activation Reactions Using Combined Mass Spectrometry and Theoretical Methods ISBN: 9811351570 ISBN-13(EAN): 9789811351570 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The reactions investigated include: (i) a nitrile-containing template-assisted meta-selective C-H activation, (ii) Pd/mono-N-protected amino acid (MPAA) catalyzed meta-selective C-H activation, (iii) Pd/MPAA catalyzed asymmetric C-H activation reactions, and (iv) Cu-catalyzed sp3 C-H cross-dehydrogenative-coupling reaction.
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