Introduction to clinical trials, Cook, Prof Jonathan A. (associate Professor, Associate Professor, Centre For Statistics In Medicine, Nuffield Department Of Orthopaedics, Rheumatology

Автор: Provan, Drew
Название: Oxford Handbook of Clinical and Laboratory Investigation
ISBN: 019876653X ISBN-13(EAN): 9780198766537
Издательство: Oxford Academ
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Цена: 38010.00 T
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Описание: Provides an authoritative guide to investigation and diagnosis. Describes key symptoms and signs, alongisde appropriate tests, and highlights pitfalls in interpreting results. Describes a clear, rational method of investigation in order to aid quick and efficient diagnosis, and prevent over-investigation of patients.

Автор: Lawrence M. Friedman; Curt D. Furberg; David L. De
Название: Fundamentals of Clinical Trials
ISBN: 3319307738 ISBN-13(EAN): 9783319307732
Издательство: Springer
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Цена: 46570.00 T
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Описание: This is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials. The three authors of the first four editions have been joined by two others who add great expertise. A chapter on regulatory issues has been included and the chapter on data monitoring has been split into two and expanded. Many contemporary clinical trial examples have been added. There is much new material on adverse events, adherence, issues in analysis, electronic data, data sharing and international trials. This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials to illustrate the fundamentals. The text is organized sequentially from defining the question to trial closeout. One chapter is devoted to each of the critical areas to aid the clinical trial researcher. These areas include pre-specifying the scientific questions to be tested and appropriate outcome measures, determining the organizational structure, estimating an adequate sample size, specifying the randomization procedure, implementing the intervention and visit schedules for participant evaluation, establishing an interim data and safety monitoring plan, detailing the final analysis plan and reporting the trial results according to the pre-specified objectives. Although a basic introductory statistics course is helpful in maximizing the benefit of this book, a researcher or practitioner with limited statistical background would still find most if not all the chapters understandable and helpful. While the technical material has been kept to a minimum, the statistician may still find the principles and fundamentals presented in this text useful.

Автор: Caroline Rodgers, Richard Harrington
Название: Helping Hands: An Introduction to Diagnostic Strategy and Clinical Reasoning, First Edition
ISBN: 1138330825 ISBN-13(EAN): 9781138330825
Издательство: Taylor&Francis
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Цена: 34700.00 T
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Описание: This brand-new textbook introduces medical students, junior doctors, medical educators and allied health professionals to the vital skills of diagnostic strategy and clinical reasoning, both essential components of becoming an effective clinician.

Автор: Caroline Rodgers, Richard Harrington
Название: Helping Hands: An Introduction to Diagnostic Strategy and Clinical Reasoning, First Edition
ISBN: 1138330868 ISBN-13(EAN): 9781138330863
Издательство: Taylor&Francis
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Цена: 112290.00 T
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Описание: This brand-new textbook introduces medical students, junior doctors, medical educators and allied health professionals to the vital skills of diagnostic strategy and clinical reasoning, both essential components of becoming an effective clinician.

Автор: Mark B. Mengel; Scott A. Fields
Название: Introduction to Clinical Skills
ISBN: 1475770820 ISBN-13(EAN): 9781475770827
Издательство: Springer
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Цена: 93160.00 T
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Автор: J. Rick Turner
Название: New Drug Development
ISBN: 1493900919 ISBN-13(EAN): 9781493900916
Издательство: Springer
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Цена: 174130.00 T
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Описание: Optimum quality data facilitate optimum quality statistical analysis and interpretation of the results obtained, which in turn permit optimum quality decisions to be made: Rational decision making is predicated on appropriate research questions and optimum quality numerical information.

Автор: Takashi Daimon; Akihiro Hirakawa; Shigeyuki Matsui
Название: An Introduction to Dose-Finding Methods in Early Phase Clinical Trials
ISBN: 4431555846 ISBN-13(EAN): 9784431555841
Издательство: Springer
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Цена: 46570.00 T
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Описание: Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs.

Автор: Tsiatis
Название: An Introduction To Dynamic Treatmen
ISBN: 1498769772 ISBN-13(EAN): 9781498769778
Издательство: Taylor&Francis
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Цена: 91860.00 T
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Описание: Precision medicine seeks to use data to construct principled, i.e., evidence-based, treatment strategies that dictate where, when, and to whom treatment should be applied. This book provides an accessible yet comprehensive introduction to statistical methodology for dynamic treatment regimes.

Автор: Berry, Donald A. Berry, Scott M. Carlin, Bradley P
Название: Bayesian adaptive methods for clinical trials
ISBN: 1439825483 ISBN-13(EAN): 9781439825488
Издательство: Taylor&Francis
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Цена: 112290.00 T
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Описание: Explores the growing role of Bayesian thinking in the rapidly changing world of clinical trial analysis. This book summarizes the state of clinical trial design and analysis and introduces the main ideas and potential benefits of a Bayesian alternative.

Автор: Campbell
Название: How to Design, Analyse and Report Cluster Randomised Trials in Medicine and Health Related Research
ISBN: 1119992028 ISBN-13(EAN): 9781119992028
Издательство: Wiley
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Цена: 70700.00 T
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Описание: A much-needed guide to the design and analysis of cluster randomized trials, How to Design, Analyse and Report Cluster Randomised Trials in Medicine and Health Related Research delivers practical guidance on the design and analysis of cluster randomised trials (cRCTs) in healthcare research.

Автор: Fregni
Название: Clinical Trials in Neurology
ISBN: 1493978799 ISBN-13(EAN): 9781493978793
Издательство: Springer
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Цена: 144410.00 T
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Описание: This volume provides in-depth descriptions and discussion of clinical trial designs based on novel data analysis of high-quality trials for 11 different neurological conditions in order to ultimately improve the quality of care in neurology. Some of the conditions discussed in this book are stroke, traumatic brain injury, Alzheimer’s disease, epilepsy, and tumors of the central nervous system. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your research center and clinical investigation. Thorough and comprehensive, Clinical Trials in Neurology is a valuable guide for individuals in the research, education, and clinical practice fields, specifically in the fields of medicine, physical therapy, occupational therapy, nursing, and public health. This volume is also an important resource for clinicians aiming to improve their understanding in methodology of clinical trials.

Автор: Shuster
Название: CRC Handbook of Sample Size Guidelines for Clinical Trials
ISBN: 1138105392 ISBN-13(EAN): 9781138105393
Издательство: Taylor&Francis
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Цена: 193950.00 T
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Описание: This volume helps medical researchers design clinical trials to improve survival, remission duration, or time to recurrence of disease. Written in a user-friendly step-by-step format, this work enables researchers, even those with no background in statistics, determine sample size and write statistical considerations for their protocols.