Efficacy Analysis in Clinical Trials an Update, Ton J. Cleophas; Aeilko H. Zwinderman
Автор: Fairclough Название: Design and Analysis of Quality of Life Studies in Clinical Trials, Second Edition ISBN: 1420061178 ISBN-13(EAN): 9781420061178 Издательство: Taylor&Francis Рейтинг: Цена: 148010.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Presents a range of solutions to analytic issues. This title reflects developments in methodology with coverage of mixture models and a dataset example. It implements examples using SAS and R code and incorporates a number of examples from real QoL clinical trials to illustrate design and analysis methods.
Автор: Shein-Chung Chow Название: Design and Analysis of Clinical Trials: Concepts and Methodologies, 2nd Edition ISBN: 0471249858 ISBN-13(EAN): 9780471249856 Издательство: Wiley Рейтинг: Цена: 135170.00 T Наличие на складе: Невозможна поставка. Описание: Praise for the First Edition of Design and Analysis of Clinical Trials
Автор: Francesco Chiappelli; Xenia Maria Caldeira Brant; Название: Comparative Effectiveness and Efficacy Research and Analysis for Practice (CEERAP) ISBN: 3662508036 ISBN-13(EAN): 9783662508039 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Recent trends in health care across the United States and internationally have emphasized a novel approach that consists in comparing the effectiveness and efficacy of treatment interventions with a patient-centered emphasis (i.e., evidence-based health care), while ensuring cost constraints, maximizing benefits, and minimizing risks. In this book, experts in comparative effectiveness and efficacy research and analysis for practice (CEERAP) in health care in general address a range of topical issues. The emphasis is on implications for endodontics and nursing, both of which are considered in a series of detailed chapters. Commonalities and differences among CEERAP, utility-based and logic-based analysis and decision-making, and evidence-based and patient-centered practice are defined and discussed. The book concludes by examining applications for CEERAP in developing patient-centered optimal treatment interventions for the next decade.
Автор: Giovanni Vecchiato; Patrizia Cherubino; Arianna Tr Название: Neuroelectrical Brain Imaging Tools for the Study of the Efficacy of TV Advertising Stimuli and their Application to Neuromarketing ISBN: 3642436765 ISBN-13(EAN): 9783642436765 Издательство: Springer Рейтинг: Цена: 113180.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In this book the authors describe their original research on the potential of both standard and high-resolution electroencephalography (EEG) for analyzing brain activity in response to TV advertising.
Автор: Nicola Brunetti-Pierri Название: Safety and Efficacy of Gene-Based Therapeutics for Inherited Disorders ISBN: 3319534556 ISBN-13(EAN): 9783319534558 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In this book, leading international experts analyze state-of-the-art advances in gene transfer vectors for applications in inherited disorders and also examine the toxicity profiles of these methods.
Автор: Rabbee, Nusrat Название: Biomarker Analysis in Clinical Trials with R ISBN: 1138368830 ISBN-13(EAN): 9781138368835 Издательство: Taylor&Francis Рейтинг: Цена: 117390.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The book offers practical guidance on how to incorporate biomarker data analysis in clinical trial studies. The book discusses the appropriate statistical methods for evaluating pharmacodynamic, predictive and surrogate biomarkers for delivering increased value in the drug development process.
Автор: Stephen L. George, Xiaofei Wang, Herbert Pang Название: Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis ISBN: 0367261170 ISBN-13(EAN): 9780367261177 Издательство: Taylor&Francis Рейтинг: Цена: 50010.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book provides statisticians with an understanding of the critical challenges currently encountered in oncology trials. The book covers state-of-the-art approaches to the design and analysis of cancer clinical trials, such as adaptive designs, biomarker-based trials, and dynamic treatment regimes.
Автор: Matsui Shigeyuki Название: Design and Analysis of Clinical Trials for Predictive Medicine ISBN: 1466558156 ISBN-13(EAN): 9781466558151 Издательство: Taylor&Francis Рейтинг: Цена: 117390.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Design and Analysis of Clinical Trials for Predictive Medicine provides statistical guidance on conducting clinical trials for predictive medicine. It covers statistical topics relevant to the main clinical research phases for developing molecular diagnostics and therapeutics--from identifying molecular biomarkers using DNA microarrays to confirming their clinical utility in randomized clinical trials.
The foundation of modern clinical trials was laid many years before modern developments in biotechnology and genomics. Drug development in many diseases is now shifting to molecularly targeted treatment. Confronted with such a major break in the evolution toward personalized or predictive medicine, the methodologies for design and analysis of clinical trials is now evolving.
This book is one of the first attempts to contribute to this evolution by laying a foundation for the use of appropriate statistical designs and methods in future clinical trials for predictive medicine. It is a useful resource for clinical biostatisticians, researchers focusing on predictive medicine, clinical investigators, translational scientists, and graduate biostatistics students.
Using time-to-event analysis methodology requires careful definition of the event, censored observation, provision of adequate follow-up, number of events, and independence or noninformativeness of the censoring mechanisms relative to the event. Design and Analysis of Clinical Trials with Time-to-Event Endpoints provides a thorough presentation of the design, monitoring, analysis, and interpretation of clinical trials in which time-to-event is of critical interest.
After reviewing time-to-event endpoint methodology, clinical trial issues, and the design and monitoring of clinical trials, the book focuses on inferential analysis methods, including parametric, semiparametric, categorical, and Bayesian methods; an alternative to the Cox model for small samples; and estimation and testing for change in hazard. It then presents descriptive and graphical methods useful in the analysis of time-to-event endpoints. The next several chapters explore a variety of clinical trials, from analgesic, antibiotic, and antiviral trials to cardiovascular and cancer prevention, prostate cancer, astrocytoma brain tumor, and chronic myelogonous leukemia trials. The book then covers areas of drug development, medical practice, and safety assessment. It concludes with the design and analysis of clinical trials of animals required by the FDA for new drug applications.
Drawing on the expert contributors' experiences working in biomedical research and clinical drug development, this comprehensive resource covers an array of time-to-event methods and explores an assortment of real-world applications.
Автор: Mallinckrodt, Craig Molenberghs, Geert Lipkovich, Ilya (quintiles, Durham, North Carolina, Usa) Ratitch, Bohdana (eli Lilly Cananda, Ontario, Canada) Название: Estimands, estimators and sensitivity analysis in clinical trials ISBN: 1138592501 ISBN-13(EAN): 9781138592506 Издательство: Taylor&Francis Рейтинг: Цена: 117390.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book will use the new guidance as a framework for developing and implementing comprehensive analysis plans for clinical trials that support the development and approval of medical interventions.
Автор: Glick, Henry A.; Doshi, Jalpa A.; Sonnad, Seema S. Название: Economic Evaluation in Clinical Trials ISBN: 0199685029 ISBN-13(EAN): 9780199685028 Издательство: Oxford Academ Рейтинг: Цена: 68640.00 T Наличие на складе: Поставка под заказ. Описание: A a practical guide to the techniques and issues involved in conducting economic evaluation in ongoing clinical trials, supported with detailed advice on the design and analysis of studies including analysis of cost effectiveness and methodological integrity.
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