Автор: Hughes Название: Translational Toxicology ISBN: 3319801430 ISBN-13(EAN): 9783319801438 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Поставка под заказ. Описание: Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology—a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and potential translational toxicology therapeutics. The result is a compelling application of developmental toxicology in a new therapeutic discipline that is destined to become part of standard medical practice. Translational Toxicology: Defining a New Therapeutic Discipline is an essential text for regulatory authorities, scientists, and physicians who are concerned with environmental exposures, public health, nutrition, and pharmaceutical research and development. Basic science, epidemiological, and clinical investigators will also find this book a significant resource.
Автор: Wehling, Martin Название: Principles Of Translational Science In Medicine ISBN: 0128204931 ISBN-13(EAN): 9780128204931 Издательство: Elsevier Science Рейтинг: Цена: 140360.00 T Наличие на складе: Поставка под заказ. Описание: Collins CSEC (R) Human and Social Biology provides a new approach to the study of the CSEC (R) HSB syllabus that focuses on the skills of recalling facts, applying facts and analysing data as needed for the examination and School Based Assessment. It provides the content and skills that students truly need to master to pass - and do well in - the exam.
Автор: Tao, Ya-Xiong Название: G Protein-Coupled Receptors In Energy Homeostasis And Obesity Pathogenesis,114 ISBN: 0123869331 ISBN-13(EAN): 9780123869333 Издательство: Elsevier Science Рейтинг: Цена: 132500.00 T Наличие на складе: Поставка под заказ. Описание: Obesity is an epidemic with enormous health, economic and social burdens. Current drugs for obesity treatment are far from ideal in terms of efficacy and side effects. This book summarizes the status in studies of a number of G protein-coupled receptors that were shown to be promising targets for obesity treatments.
Автор: Mohammad A. Tabrizi; Gadi G. Bornstein; Scott L. K Название: Development of Antibody-Based Therapeutics ISBN: 9811344329 ISBN-13(EAN): 9789811344329 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Поставка под заказ. Описание: The biologics market continues to witness an impressive rate of growth and the monoclonal antibody market, in particular, has contributed remarkably to the expansion of this segment within the pharmaceutical industry. In 2006, close to 80% of the annual biologics growth rate in the United States (US) was attributed to cancer and anti-TNF antibodies, with increases in growth of 56% and 25%, respectively, compared to those in the previous year. Additionally, the monoclonal antibody sector is anticipated to achieve a growth rate of approximately 14% by 2012, easily outstripping the predicted 0.6% growth rate in the small molecules market. The robust late-stage antibody pipeline within the biotech sector has drawn an increasing amount of interest from the large pharmaceutical industry and has triggered the largest product and platform deals in 2006, with values more than $2.1 and $5.1 billion in partnering and mergers and acquisitions, respectively. Additionally, with the forthcoming emergence of biogenerics, next-generation bio-improved antibodies have drawn much attention and increasingly contribute to the growth of the biologics segment. As next-generation monoclonal antibodies confront their first-generation rivals, it is critical that these next-generation products offer a clear differentiating advantage against the existing competition. Successful strategies for the development of monoclonal antibodies require integration of knowledge with respect to target antigen properties, antibody design criteria such as affinity, isotype selection, Fc domain engineering, pharmacokinetic and pharmacodynamic (PK/PD) properties, antibody cross-reactivity across species, market differentiation opportunities for the first- and next-generation leads, and regulatory requirements from the early stages of antibody development. Biophysical measurements are one of the critical components necessary for the design of effective translational strategies for lead selection and evaluation of relevant animal species for preclinical safety and efficacy studies. Incorporation of effective translational strategies from the early stages of the antibody development process is a necessity, and when considered, it not only reduces development time and cost, but also fosters implementation of rational decision-making throughout all phases of antibody development. Translational strategies for development of antibody-based therapeutics should allow understanding of the relationship between the 'unit dose' and 'unit effect' with respect to both beneficial and deleterious effects from early stages of development. The flow of information from later to earlier stages of development should provide opportunities to facilitate selection of more effective and novel next-generation drug candidates. Selection and evaluation of relevant biomarkers in early preclinical development in "relevant" animal models should allow for identifying potential risks to humans and establishing safe First-In-Human (FIH) dosing strategies. Hence, integration of knowledge with respect to target antigen properties such as antigen distribution, expression profile, kinetic properties, target pharmacology, antigen isoforms and pharmacological redundancy in health and disease, as well as antibody design criteria, such as antibody isotype, affinity, PK/PD and safety is a critical necessity for the design of effective translational strategies. Additionally, these factors will further offer critical differentiating characteristics for next-generation antibodies, and novel technologies prove instrumental in generation of bio-improved antibody candidates for market entry. This book will examine many important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics.
Автор: Rahman, Shafiqur Название: The Brain As A Drug Target,98 ISBN: 0123855063 ISBN-13(EAN): 9780123855060 Издательство: Elsevier Science Рейтинг: Цена: 140360.00 T Наличие на складе: Поставка под заказ. Описание: The brain is protected by the blood-brain barrier and this barrier prevents many drugs from entering the brain. This title discusses various drug delivery and targeting strategies that are being developed to enhance the transport and distribution of drugs into the brain. It discusses discoveries, approaches, and ideas.
Автор: Robbins Trevor W., Sahakian Barbara J. Название: Translational Neuropsychopharmacology ISBN: 3319816306 ISBN-13(EAN): 9783319816302 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.
Автор: Estelle B. Gauda; Maria Emilia Monteiro; Nanduri P Название: Arterial Chemoreceptors ISBN: 3030081842 ISBN-13(EAN): 9783030081843 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Поставка под заказ. Описание:
This volume contains reviews and brief research articles from participants attending the International Society for Arterial Chemoreception meeting, to be held in the USA (July 2017). Each article contains original data and represents up-to-date information concerning the carotid body and oxygen sensing in health and disease. This volume is a required text for all researchers in the field of arterial chemoreception and will provide a valuable reference source for years to come.
Автор: Cokkinos Название: Myocardial Preservation ISBN: 3319981854 ISBN-13(EAN): 9783319981857 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Поставка под заказ. Описание: This timely book reveals an integrated approach to myocardial preservation focusing on translational research and clinical applications.
Автор: Krentz Название: Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease ISBN: 3030117472 ISBN-13(EAN): 9783030117474 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Поставка под заказ. Описание: This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders. Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g.
Автор: Cacabelos, Ram?n Название: Pharmacoepigenetics ISBN: 0128139390 ISBN-13(EAN): 9780128139394 Издательство: Elsevier Science Рейтинг: Цена: 176290.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Pharmacoepigenetics, Volume Eleven provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development.
Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine.
Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development
Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry
Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety
Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine
Автор: Andrew J. Krentz; Lutz Heinemann; Marcus Hompesch Название: Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development ISBN: 1447170326 ISBN-13(EAN): 9781447170327 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book reviews techniques for assessing insulin action, insulin secretion and body composition, with reference to new drugs, in phase 1 & 2 studies. Adds to understanding of drug effects and non-drug treatment strategies in obesity and type 2 diabetes.
Автор: Sadegh Babashah Название: Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology ISBN: 331936393X ISBN-13(EAN): 9783319363936 Издательство: Springer Рейтинг: Цена: 139310.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The concept of cancer stem cells has great clinical implications. Although there are some huge gaps in our current understanding of the role played by cancer stem cells in cancer biology, a growing body of evidence provides strong support for the principal functions of these cells in tumorigenesis.
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