G Protein-Coupled Receptors In Energy Homeostasis And Obesity Pathogenesis,114, Tao, Ya-Xiong
Автор: Danielle Pansu; Felix Bronner Название: Calcium Transport and Intracellular Calcium Homeostasis ISBN: 3642839797 ISBN-13(EAN): 9783642839795 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of the NATO Advanced Research Workshop on Calcium Transport and Intracellular Calcium Homeostasis held in Lyon, France, March 4-7, 1990
Автор: T. Godfraind; G. Mancia; M.P. Abbracchio; L. Aguil Название: Pharmacological Control of Calcium and Potassium Homeostasis ISBN: 9401040567 ISBN-13(EAN): 9789401040563 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: As the number of drugs acting on calcium and potassium channels grows, there is a need for a continuous reappraisal of the cellular machinery controlling them. Calcium homeostasis within the cell is not only regulated by calcium channels;
Название: G Protein-Coupled Receptors ISBN: 0367392372 ISBN-13(EAN): 9780367392376 Издательство: Taylor&Francis Рейтинг: Цена: 65320.00 T Наличие на складе: Невозможна поставка. Описание: With contributions from international experts in the fields of pharmacology, neuroscience, and biochemistry, this text provides an in-depth exploration of GPCRs. Coverage includes the screening of ligands for GPCRs, physiological and molecular characterizations of GPCRs, and structures of GPCRs and their ligands. The book explores current research issues in the post-genome era, particularly the identification of endogenous ligands that may lead to finding new hormones or neurotransmitters. It also discusses the determination of the tertiary structure of GPCRs, useful for understanding GPCR interactions and for the theoretical modeling of drugs.
Автор: E. Carafoli; J. Krebs Название: Calcium Homeostasis ISBN: 3642635326 ISBN-13(EAN): 9783642635328 Издательство: Springer Рейтинг: Цена: 104480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: With contributions by numerous experts
Автор: Conn, P. Michael Название: G Protein Coupled Receptors,521 ISBN: 0123918626 ISBN-13(EAN): 9780123918628 Издательство: Elsevier Science Рейтинг: Цена: 154960.00 T Наличие на складе: Поставка под заказ. Описание: Covering G protein coupled receptors, this title includes chapters on such topics as G protein-coupled receptor trafficking motifs, and automation-friendly high throughput assays for identification of pharmacoperone drugs.
Автор: Kenakin, Terry Название: Oligomerization And Allosteric Modulation In G-Protein Coupled Receptors,115 ISBN: 0123945879 ISBN-13(EAN): 9780123945877 Издательство: Elsevier Science Рейтинг: Цена: 132500.00 T Наличие на складе: Поставка под заказ. Описание: Reflects on developments and research surrounding G protein-coupled receptors. This title includes chapters that cover a large breadth of research, including GPCR role in stem cell function and pharmacology.
Автор: Filizola Название: G Protein-Coupled Receptors in Drug Discovery ISBN: 1493949675 ISBN-13(EAN): 9781493949670 Издательство: Springer Рейтинг: Цена: 102480.00 T Наличие на складе: Поставка под заказ. Описание: This detailed volume provides an overview of recent techniques employed in the field of G protein-coupled receptors (GPCRs) to screen for new drugs and to derive information about their receptor structure, dynamics, and function for the purpose of developing improved therapeutics. Owing to remarkable recent advances in the structural, biophysical and biochemical analyses of these receptors, as well as a growing body of evidence hinting at the possible relevance of allosteric modulators, biased agonists and oligomer-selective ligands as improved therapeutic agents, drug discovery for GPCRs has recently taken a completely new direction. For this book, expert contributors have shared their protocols and views on the impact of these methodologies on modern drug discovery. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Practical and fully updated, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, Second Edition serves as an ideal guide for a diverse audience from structural and molecular biologists to pharmacologists and drug designers who wish to explore this extensive class of key drug targets.
Название: G Protein-Coupled Receptors ISBN: 0367455609 ISBN-13(EAN): 9780367455606 Издательство: Taylor&Francis Рейтинг: Цена: 63280.00 T Наличие на складе: Невозможна поставка. Описание: Covering recently developed methods in membrane-bound receptors, this book emphasizes receptor structure and function. This book provides a broad base of knowledge. Topics include the regulation of receptors; phosphorylation of G-protein-coupled receptors and ion channel receptors; desensitization studies using electrophysiological or confocal micr
Автор: Kim Neve Название: Functional Selectivity of G Protein-Coupled Receptor Ligands ISBN: 1493961160 ISBN-13(EAN): 9781493961160 Издательство: Springer Рейтинг: Цена: 174130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In Functional Selectivity of G Protein-Coupled Receptors, experts review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon.
From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo‐switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP‐1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction, RAMPs as allosteric modulators of Class B GPCRs, Structure‐based discovery and development of mGlu5 NAMs, and much more.
Автор: Tao, Ya-Xiong Название: G Protein-Coupled Receptors In Health And Disease, Part B,89 ISBN: 0123747562 ISBN-13(EAN): 9780123747563 Издательство: Elsevier Science Рейтинг: Цена: 140360.00 T Наличие на складе: Поставка под заказ. Описание: G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. This book reviews the developments in this field. Discussing discoveries, approaches, and ideas, it is suitable for researchers involved in molecular biology.
Автор: Langenhan Название: Adhesion G Protein-coupled Receptors ISBN: 3319823752 ISBN-13(EAN): 9783319823751 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Поставка под заказ. Описание: Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function.
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