Using Mass Spectrometry for Drug Metabolism Studies, Korfmacher, Walter A.
Название: Using Mass Spectrometry for Drug Metabolism Studies ISBN: 0367384957 ISBN-13(EAN): 9780367384951 Издательство: Taylor&Francis Рейтинг: Цена: 65320.00 T Наличие на складе: Нет в наличии. Описание:
The first edition of this now classic work helped to establish mass spectrometry as the premier tool for drug metabolism studies. Completely rewritten from start to finish, Using Mass Spectrometry for Drug Metabolism Studies, Second Edition brings medicinal chemists and mass spectrometry professionals up to speed with the rapid advances in the field, the emergence of cutting-edge approaches, and ways to meet steadily increasing vendor demands. Written by international scientists who are experts in their respective disciplines, this state-of-the-art reference effectively encapsulates current mass spectrometry best practices.
The stand-alone chapters cover various topics - from metabolite identification to fast chromatography with UPLC - and in a style that is understandable to experts and field newcomers alike. The second edition of this bestseller includes coverage of new instrumentation and software as well as a wealth of updated information on the latest findings surrounding biomarkers and metabolomics and new chapters on both UPLC and DESI/DART.
With more than 180 illustrations and an eight-page color insert, this valuable reference explores multiple modern mass spectrometry techniques and strategies. It includes an excellent overview of the entire drug discovery process plus the latest developments on how mass spectrometry is used to support this endeavor.
Автор: Frigerio Название: Mass Spectrometry in Drug Metabolism ISBN: 1461341531 ISBN-13(EAN): 9781461341536 Издательство: Springer Рейтинг: Цена: 81050.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: When a dose of drug is administered, three main phases of drug action may be distingushed.
Автор: Datta Susmita, Mertens Bart J. a. Название: Statistical Analysis of Proteomics, Metabolomics, and Lipidomics Data Using Mass Spectrometry ISBN: 3319833774 ISBN-13(EAN): 9783319833774 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book presents an overview of computational and statistical design and analysis of mass spectrometry-based proteomics, metabolomics, and lipidomics data. This contributed volume provides an introduction to the special aspects of statistical design and analysis with mass spectrometry data for the new omic sciences. The text discusses common aspects of design and analysis between and across all (or most) forms of mass spectrometry, while also providing special examples of application with the most common forms of mass spectrometry. Also covered are applications of computational mass spectrometry not only in clinical study but also in the interpretation of omics data in plant biology studies. Omics research fields are expected to revolutionize biomolecular research by the ability to simultaneously profile many compounds within either patient blood, urine, tissue, or other biological samples. Mass spectrometry is one of the key analytical techniques used in these new omic sciences. Liquid chromatography mass spectrometry, time-of-flight data, and Fourier transform mass spectrometry are but a selection of the measurement platforms available to the modern analyst. Thus in practical proteomics or metabolomics, researchers will not only be confronted with new high dimensional data types—as opposed to the familiar data structures in more classical genomics—but also with great variation between distinct types of mass spectral measurements derived from different platforms, which may complicate analyses, comparison, and interpretation of results.
Автор: Huibin Wei Название: Studying Cell Metabolism and Cell Interactions Using Microfluidic Devices Coupled with Mass Spectrometry ISBN: 3642430864 ISBN-13(EAN): 9783642430862 Издательство: Springer Рейтинг: Цена: 87060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book describes a new approach for cell analysis by the rapid developing microfluidic technology. It develops a new analysis platform which combined microfluidic devices with mass spectrometry to determine the trace compounds secreted by cells.
Автор: Vladimir A. Krasnopolsky Название: Spectroscopy and Photochemistry of Planetary Atmospheres and Ionospheres: Mars, Venus, Titan, Triton and Pluto ISBN: 1107145260 ISBN-13(EAN): 9781107145269 Издательство: Cambridge Academ Рейтинг: Цена: 83430.00 T Наличие на складе: Поставка под заказ. Описание: This book provides a detailed overview of the fundamental principles and methods of spectroscopy and photochemical modeling for studying the chemical composition of planetary atmospheres and ionospheres. With detailed reviews of Mars, Venus, Titan, Triton and Pluto, it is a valuable reference for graduate students, researchers and planetary scientists.
Автор: Bolgar Mark S. Название: Mass Spectrometry in Biopharmaceutical and Emerging Drug Modalities ISBN: 1782629750 ISBN-13(EAN): 9781782629757 Издательство: Royal Society of Chemistry Рейтинг: Цена: 223870.00 T Наличие на складе: Невозможна поставка. Описание: The focus of this book is on the use of mass spectrometry (MS) for the assessment of alternative modes of drug efficacy and inclusion of information on the use of MS in the development of protein biosimilars.
Автор: Rossi, David T. Название: Mass Spectrometry in Drug Discovery ISBN: 0824706072 ISBN-13(EAN): 9780824706074 Издательство: Taylor&Francis Рейтинг: Цена: 224570.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Название: High-throughput mass spectrometry in drug discovery ISBN: 1119678439 ISBN-13(EAN): 9781119678434 Издательство: Wiley Рейтинг: Цена: 179520.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Korfmacher Название: Mass Spectrometry for Drug Discovery and Drug Deve lopment ISBN: 047094238X ISBN-13(EAN): 9780470942383 Издательство: Wiley Рейтинг: Цена: 120330.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Jenner Matthew Название: Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases ISBN: 3319813552 ISBN-13(EAN): 9783319813554 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This thesis reports studies on the substrate specificity of crucial ketosynthase (KS) domains from trans-AT Polyketide Synthases (PKSs). Using a combination of electrospray ionisation-mass spectrometry (ESI-MS) and simple N-acetyl cysteamine (SNAC) substrate mimics, the specificity of a range of KS domains from the bacillaene and psymberin PKSs have been succsessfully studied with regard to the initial acylation step of KS-catalysis. In addition, the ability to alter the substrate tolerance of KS domains by simple point mutations in the active site has been demonstrated. A series of acyl-ACPs have been synthesised using a novel methodology and employed to probe the substrate specificity of both KS domains and the previously uncharcterised acyl hydrolase domain, PedC. KS-catalysed chain elongation reactions have also been conducted and monitored by ESI-MS/MS. All KS domains studied exhibited higher substrate specificity at the elongation step than in the preceeding acylation step. Furthermore, a mechanism of reversible acylation is proposed using the PsyA ACP1-KS1 di-domain. The findings in this thesis provide important insights into mechanisms of KS specificity and show that mutagenesis can be used to expand the repertoire of acceptable substrates for future PKS engineering.
Автор: Cheng Gui-Juan Название: Mechanistic Studies on Transition Metal-Catalyzed C-H Activation Reactions Using Combined Mass Spectrometry and Theoretical Methods ISBN: 9811351570 ISBN-13(EAN): 9789811351570 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The reactions investigated include: (i) a nitrile-containing template-assisted meta-selective C-H activation, (ii) Pd/mono-N-protected amino acid (MPAA) catalyzed meta-selective C-H activation, (iii) Pd/MPAA catalyzed asymmetric C-H activation reactions, and (iv) Cu-catalyzed sp3 C-H cross-dehydrogenative-coupling reaction.
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