G Protein-Coupled Receptors in Drug Discovery, Filizola
Название: G Protein-Coupled Receptors in Drug Discovery ISBN: 0367392518 ISBN-13(EAN): 9780367392512 Издательство: Taylor&Francis Рейтинг: Цена: 65320.00 T Наличие на складе: Нет в наличии. Описание:
The broad range of G protein-coupled receptors (GPCRs) encompasses all areas of modern medicine and have an enormous impact on the process of drug development. Using disease-oriented methods to cover everything from screening to expression and crystallization, G Protein-Coupled Receptors in Drug Discovery describes the physiological roles of GPCRs and their involvement in various human diseases.
The book presents current approaches in drug discovery that include target selection, establishment of screening and functional assays. It also covers recombinant GPCR expression for drug screening and structural biology, different methods for structural characterization of GPCRs, and the importance of bioinformatics. The book has been carefully edited to avoid overlapping information, some duplication has been intentionally permitted so that each chapter can function as an independent unit. Providing in-depth discussions on structure and dynamics of GPCRs, this book outlines the importance of the GPCRs to drug discovery in general and drug targets specifically.
Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.
Название: G Protein-Coupled Receptors: From Structure to Function ISBN: 1849731837 ISBN-13(EAN): 9781849731836 Издательство: Royal Society of Chemistry Рейтинг: Цена: 239350.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book considers the relationship between structure and function in G protein-coupled receptors (GPCRs) and the implications for drug design.
Автор: Kim Neve Название: Functional Selectivity of G Protein-Coupled Receptor Ligands ISBN: 1493961160 ISBN-13(EAN): 9781493961160 Издательство: Springer Рейтинг: Цена: 174130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In Functional Selectivity of G Protein-Coupled Receptors, experts review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon.
Название: G Protein-Coupled Receptors ISBN: 0367392372 ISBN-13(EAN): 9780367392376 Издательство: Taylor&Francis Рейтинг: Цена: 65320.00 T Наличие на складе: Невозможна поставка. Описание: With contributions from international experts in the fields of pharmacology, neuroscience, and biochemistry, this text provides an in-depth exploration of GPCRs. Coverage includes the screening of ligands for GPCRs, physiological and molecular characterizations of GPCRs, and structures of GPCRs and their ligands. The book explores current research issues in the post-genome era, particularly the identification of endogenous ligands that may lead to finding new hormones or neurotransmitters. It also discusses the determination of the tertiary structure of GPCRs, useful for understanding GPCR interactions and for the theoretical modeling of drugs.
Название: G Protein-Coupled Receptors ISBN: 0367455609 ISBN-13(EAN): 9780367455606 Издательство: Taylor&Francis Рейтинг: Цена: 63280.00 T Наличие на складе: Невозможна поставка. Описание: Covering recently developed methods in membrane-bound receptors, this book emphasizes receptor structure and function. This book provides a broad base of knowledge. Topics include the regulation of receptors; phosphorylation of G-protein-coupled receptors and ion channel receptors; desensitization studies using electrophysiological or confocal micr
From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo‐switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP‐1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction, RAMPs as allosteric modulators of Class B GPCRs, Structure‐based discovery and development of mGlu5 NAMs, and much more.
Автор: Tao, Ya-Xiong Название: G Protein-Coupled Receptors In Energy Homeostasis And Obesity Pathogenesis,114 ISBN: 0123869331 ISBN-13(EAN): 9780123869333 Издательство: Elsevier Science Рейтинг: Цена: 132500.00 T Наличие на складе: Поставка под заказ. Описание: Obesity is an epidemic with enormous health, economic and social burdens. Current drugs for obesity treatment are far from ideal in terms of efficacy and side effects. This book summarizes the status in studies of a number of G protein-coupled receptors that were shown to be promising targets for obesity treatments.
Автор: Tao, Ya-Xiong Название: G Protein-Coupled Receptors In Health And Disease, Part B,89 ISBN: 0123747562 ISBN-13(EAN): 9780123747563 Издательство: Elsevier Science Рейтинг: Цена: 140360.00 T Наличие на складе: Поставка под заказ. Описание: G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. This book reviews the developments in this field. Discussing discoveries, approaches, and ideas, it is suitable for researchers involved in molecular biology.
Автор: Shukla, Arun K. Название: G Protein-Coupled Receptors, Part B, 2nd Edition ISBN: 0128151072 ISBN-13(EAN): 9780128151075 Издательство: Elsevier Science Рейтинг: Цена: 151590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
G-Protein-Coupled Receptors, Part B, 2nd Edition, Volume 149, the latest release in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers Optical Approaches for Visualization of Arrestin Binding to Muscarinic Receptors, Luciferase Reporter Assay for Unlocking Ligand-mediated Signaling of GPCRs, Assays to Measure GPCR Dependent Cellular Migration, Characterization of the Frizzled GPCRs, Binding Assays for Bradykinin and Angiotensin Receptors, Detection of Misfolded Rhodopsin Aggregates in Cells, Measuring GPCR Ubiquitination and Trafficking, Culture of Primary Neurons and its Use in Studying GPCR Trafficking, and much more.
Covers the increasingly appreciated cell biology field of G-protein-coupled receptors
Includes both established and new technologies
Contributed by experts in the field
Название: Allosteric modulation of g protein-coupled receptors ISBN: 0128197714 ISBN-13(EAN): 9780128197714 Издательство: Elsevier Science Рейтинг: Цена: 129130.00 T Наличие на складе: Поставка под заказ. Описание: "The classic account of the human tendency to follow orders, no matter who they hurt or what their consequences." - Washington Post Book WorldIn the 1960s, Yale University psychologist Stanley Milgram famously carried out a series of experiments that forever changed our perceptions of morality and free will.
Автор: Langenhan Название: Adhesion G Protein-coupled Receptors ISBN: 3319823752 ISBN-13(EAN): 9783319823751 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Поставка под заказ. Описание: Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function.
Автор: Arun K. Shukla Название: G Protein-Coupled Receptors: Signaling, Trafficking and Regulatio ISBN: 0128035951 ISBN-13(EAN): 9780128035955 Издательство: Elsevier Science Рейтинг: Цена: 141480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
"G-Protein-Coupled Receptors: Signaling, Trafficking, and Regulation," a new volume in the "Methods in Cell Biology" series continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in G-Protein-Coupled Receptors, and includes sections on such topics signaling, trafficking and regulation. Covers the increasingly appreciated cell biology field of G-protein-coupled receptorsIncludes both established and new technologiesContributed by experts in the fieldCovers topics such as signaling, trafficking, and regulation
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