The Role of Pendrin in Health and Disease, Silvia Dossena; Markus Paulmichl

Автор: Sylvia B. Smith; Tsung-Ping Su
Название: Sigma Receptors: Their Role in Disease and as Therapeutic Targets
ISBN: 3319501720 ISBN-13(EAN): 9783319501727
Издательство: Springer
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Цена: 158380.00 T
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Описание: Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets.

Автор: Maya Ashford
Название: Parathyroid Glands: Regulation, Role in Human Disease & Indications for Surgery
ISBN: 1631172298 ISBN-13(EAN): 9781631172298
Издательство: Nova Science
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Цена: 103480.00 T
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Описание: Parathyroid glands are endodermal-derived organs responsible for the production of the parathyroid hormone (PTH), an essential regulator of calcium homeostasis. The role of the parathyroids in human diseases is almost exclusively related to its hyperfunction, mainly mediated via primary hyperparathyroidism, which is a relatively common disease and is the main cause of hypercalcemia in outpatients. This book discusses the development of parathyroid glands and c-cells; homeostasis, disease and indications for surgical treatment in the parathyroid glands; hyperfunction in the parathyroid glands; contemporary surgical management or primary hyperparathyroidism; and the role of parathyroid hormones in heart failure.

Автор: Sylvia B. Smith; Tsung-Ping Su
Название: Sigma Receptors: Their Role in Disease and as Therapeutic Targets
ISBN: 3319843354 ISBN-13(EAN): 9783319843353
Издательство: Springer
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Цена: 158380.00 T
Наличие на складе: Поставка под заказ.
Описание: Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets.

Автор: Han Asard; Alajos B?rczi; Roland J. Caubergs
Название: Plasma Membrane Redox Systems and their role in Biological Stress and Disease
ISBN: 0792354672 ISBN-13(EAN): 9780792354673
Издательство: Springer
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Цена: 213360.00 T
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Описание: Provides a treatment of the involvement of plasma membrane redox reactions in the origin and development of biological stress and disease. This book contains chapters which cover the role of plasma membrane redox systems in cell defence, growth control, antioxidative defence reactions, development of tumour cells, and entry of toxins and viruses.

Автор: Dennis Hertz
Название: Ghrelin: Function, Mechanism of Action and Role in Health and Disease
ISBN: 1536168513 ISBN-13(EAN): 9781536168518
Издательство: Nova Science
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Цена: 77080.00 T
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Описание: Ghrelin is a 28-amino acid peptide mainly secreted by the stomach. To better understand the role of ghrelin signaling, Ghrelin: Function, Mechanism of Action and Role in Health and Disease first explores the regulation of age-associated adipose tissue inflammation. Following this, the authors discuss the influence of different variables on the response of short-term appetite regulation induced by exercise. External factors such as temperature and environment exert effects on hormonal responses, including hunger sensation and energy intake. The effects of gender differences and aging on psychological stress-dependent eating disorders are assessed, and the involvement of endogenous ghrelin, the serotonin 2c receptor and the estrogen alpha receptor is discussed. The penultimate chapter reviews the relationship between sleep and eating behavior, focusing in the influences of circadian changes on appetite related responses such as plasma concentration of ghrelin. The concluding study highlights the ghrelin system as a promising candidate for cardiovascular drug discovery, a new therapeutic approach for the treatment of endothelial impairment, and a possible contribution to the prevention of atherosclerosis.

Автор: Monte Stevens
Название: p53: Structure, Functions and Role in Disease
ISBN: 1536187712 ISBN-13(EAN): 9781536187717
Издательство: Nova Science
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Цена: 89750.00 T
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Описание: p53: Structure, Functions and Role in Disease discusses the role of p53 dysregulation in different hematologic neoplasms defined by the current WHO classification. The prevalence of p53 aberration, mechanisms of p53 inactivation, regulation of p53 signaling pathway, and prognostic implications of p53 dysfunction in different hematologic malignancies are reviewed. The authors also discuss the prevalence of p53 mutations in cancers and important mechanisms underlying the impact of p53 mutations such as loss of function, dominant negative effect and gain of function. Recent findings related to the p53-mediated neuroprotective effects of natural compounds at the cellular, molecular, and behavioral level in various in vitro and in vivo models of neurodegenerative diseases are described, with a focus on Alzheimers disease.

Автор: Charles D. Bluestone
Название: Eustachian Tube: Structure, Function, and Role in Middle-Ear Disease
ISBN: 1607951967 ISBN-13(EAN): 9781607951964
Издательство: Mare Nostrum (Eurospan)
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Цена: 62700.00 T
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Описание: Includes a focus not only on the structure and function of the Eustachian tube (ET) and its role in the pathogenesis of middle-ear disease and related conditions, but also how this impacts the clinician`s management of middle-ear disease. Presented in this one source is the current state of knowledge of the ET within its ""system"".

Автор: Ayako Himura, Takeshi Sato
Название: Renin-Angiotensin System: Physiology, Role in Disease & Health Implications
ISBN: 1624177883 ISBN-13(EAN): 9781624177880
Издательство: Nova Science
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Цена: 224920.00 T
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Описание: The renin-angiotensin system (RAS) is a major hormonal system that plays an essential role in regulating salt-water balance and blood pressure. In this book, the authors discuss the physiology, role in disease and health implications of RAS. Topics include the function of the renin-angiotension-aldosterone system in ISIAH rats with stress-sensitive arterial hypertension; RAS implications for eye diseases, obesity and diabetes, and cardiovascular disease; intensive blockade of renin-angiotensin systems; glomerular renin-angiotensin system activation; the role of vitamin D in RAS; the renin-angiotensin system in the pathogenesis of intracranial aneurysms; and a discussion on whether angiotensin-converting enzyme inhibitors are a contradiction for contrast-induced nephropathy prophylaxis?

Автор: Calista Araujo, Demetrio Perez
Название: Triglycerides: Chemical Structure, Biosynthesis & Role in Disease
ISBN: 1624177271 ISBN-13(EAN): 9781624177279
Издательство: Nova Science
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Цена: 196410.00 T
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Описание: The boundary between semantics and pragmatics has been important since the early twentieth century, but in the last twenty-five years it has become the central issue in the philosophy of language. This anthology collects classic philosophical papers on the topic, along with recent key contributions. It stresses not only the nature of the boundary, but also its importance for philosophy generally.

Автор: Gerald Maldonado
Название: Resistin: Structure, Function and Role in Disease
ISBN: 1536145432 ISBN-13(EAN): 9781536145434
Издательство: Nova Science
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Цена: 122490.00 T
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Описание: Over the past decade, adipose tissue has received much attention for its immunological properties. Additionally, it has become increasingly apparent that adipose-secreted factors such as leptin, tumor necrosis factor-a, IL-6, adiponectin and more recently, resistin are implicated in some inflammatory and metabolic diseases. As such, Resistin: Structure, Function and Role in Disease opens by discussing resistins therapeutic properties. Because evidence appears to suggest that resistin is a proinflammatory cytokine, resistin may impact metabolic disease.Following this, the authors present experimental and clinical evidence indicating that resistin may have functions related to inflammation and oxidative stress. The circulating resistin level may be also useful as a marker of the effects of exercise.Resistin may also encourage vasculopathy through the promotion of macrophage scavenger receptors and CD36 atheroma macrophages expression, the formation of foam cells, as well as proliferation and migration of vascular smooth muscle cells. This causes endothelial dysfunction, resulting in limited nitric oxide and increased superoxide production.When present in the diseased vessel wall, resistin may orchestrate pro-atherosclerotic events, contributing to atherosclerosis progression towards plaque rupture. Thus, resistin may augment monocyte and macrophage infiltration, interfere in cell cross-talk and modulate the expression of various inflammatory cytokines leading to the acceleration of plaque growth.Based on the known sequential events of obesity preceding severe acute pancreatitis, the authors investigate resistin as a new potential predictive marker of fat necrosis and pancreatitis severity.

Автор: Gera Neufeld; Ofra Kessler
Название: The Neuropilins: Role and Function in Health and Disease
ISBN: 3319840223 ISBN-13(EAN): 9783319840222
Издательство: Springer
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Цена: 139750.00 T
Наличие на складе: Поставка под заказ.
Описание: This book covers basic research topics such as the structure-function relationships of neuropilins and mechanisms of neuropilin-mediated signal transduction, details the most important roles of the neuropilins in developmental biology, and addresses their roles in various conditions such as cancer and various eye diseases.