p53: Structure, Functions and Role in Disease, Monte Stevens

Автор: Gerard P. Zambetti
Название: The p53 Tumor Suppressor Pathway and Cancer
ISBN: 1489998799 ISBN-13(EAN): 9781489998798
Издательство: Springer
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Цена: 174130.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells.

Автор: Gerald Maldonado
Название: Resistin: Structure, Function and Role in Disease
ISBN: 1536145432 ISBN-13(EAN): 9781536145434
Издательство: Nova Science
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Цена: 122490.00 T
Наличие на складе: Невозможна поставка.
Описание: Over the past decade, adipose tissue has received much attention for its immunological properties. Additionally, it has become increasingly apparent that adipose-secreted factors such as leptin, tumor necrosis factor-a, IL-6, adiponectin and more recently, resistin are implicated in some inflammatory and metabolic diseases. As such, Resistin: Structure, Function and Role in Disease opens by discussing resistins therapeutic properties. Because evidence appears to suggest that resistin is a proinflammatory cytokine, resistin may impact metabolic disease.Following this, the authors present experimental and clinical evidence indicating that resistin may have functions related to inflammation and oxidative stress. The circulating resistin level may be also useful as a marker of the effects of exercise.Resistin may also encourage vasculopathy through the promotion of macrophage scavenger receptors and CD36 atheroma macrophages expression, the formation of foam cells, as well as proliferation and migration of vascular smooth muscle cells. This causes endothelial dysfunction, resulting in limited nitric oxide and increased superoxide production.When present in the diseased vessel wall, resistin may orchestrate pro-atherosclerotic events, contributing to atherosclerosis progression towards plaque rupture. Thus, resistin may augment monocyte and macrophage infiltration, interfere in cell cross-talk and modulate the expression of various inflammatory cytokines leading to the acceleration of plaque growth.Based on the known sequential events of obesity preceding severe acute pancreatitis, the authors investigate resistin as a new potential predictive marker of fat necrosis and pancreatitis severity.

Автор: Gretchen Rivera
Название: Type I Collagen: Molecular Structure, Applications in Tissue Engineering & Role in Human Disorders
ISBN: 1634828291 ISBN-13(EAN): 9781634828291
Издательство: Nova Science
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Цена: 168950.00 T
Наличие на складе: Невозможна поставка.
Описание: Contains the major statutes, treaties, regulations, guidelines, and policies affecting antitrust law. This edition includes the Sherman and Clayton Acts, the most recent federal guidelines (including the 2010 and 1992 versions of the Horizontal Merger Guidelines), procedural statutes and exemptions, as well as international agreements and treaties. Useful for students and practitioners alike.

Автор: Silvia Dossena; Markus Paulmichl
Название: The Role of Pendrin in Health and Disease
ISBN: 3319827804 ISBN-13(EAN): 9783319827803
Издательство: Springer
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Цена: 139750.00 T
Наличие на складе: Поставка под заказ.
Описание: This book reviews the current state of knowledge on the genetics, molecular biology and physiology of pendrin, with a particular focus on pendrin dysfunction and the consequences for human health.