p53: Structure, Functions and Role in Disease 9781536187717

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Автор: Monte Stevens
Название: p53: Structure, Functions and Role in Disease
ISBN: 9781536187717
Издательство: Nova Science
Классификация:

Медицинская генетика

ISBN-10: 1536187712
Обложка/Формат: Paperback
Страницы: 182
Вес: 0.31 кг.
Дата издания: 06.11.2020
Язык: English
Размер: 230 x 155
Читательская аудитория: General (us: trade)
Ключевые слова: Medical genetics
Подзаголовок: Structure, functions and role in disease
Рейтинг:
Поставляется из: Англии
Описание: p53: Structure, Functions and Role in Disease discusses the role of p53 dysregulation in different hematologic neoplasms defined by the current WHO classification. The prevalence of p53 aberration, mechanisms of p53 inactivation, regulation of p53 signaling pathway, and prognostic implications of p53 dysfunction in different hematologic malignancies are reviewed. The authors also discuss the prevalence of p53 mutations in cancers and important mechanisms underlying the impact of p53 mutations such as loss of function, dominant negative effect and gain of function. Recent findings related to the p53-mediated neuroprotective effects of natural compounds at the cellular, molecular, and behavioral level in various in vitro and in vivo models of neurodegenerative diseases are described, with a focus on Alzheimers disease.

p53: Structure, Functions and Role in Disease, Monte Stevens