The Neuropilins: Role and Function in Health and Disease, Gera Neufeld; Ofra Kessler

Автор: Analise Martinez
Название: Myofibroblasts: Origin, Function & Role in Disease
ISBN: 1634857437 ISBN-13(EAN): 9781634857437
Издательство: Nova Science
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Цена: 96090.00 T
Наличие на складе: Невозможна поставка.
Описание: Myofibroblasts play a major role in connective tissue remodeling by synthesising the extracellular matrix (ECM) and by exerting contraction, both of which depend on complex and specific cell-matrix and cell-cell communications. Integrins are a major family of transmembrane receptors that directly link the intracellular cytoskeleton dynamics to extracellular structures via adhesions in all metazoans. In this book, Chapter One discusses major integrins that have an established role in the formation, function, and turnover of myofibroblasts associated with tissue remodeling. Chapter Two reviews the role of myofibroblasts in normal skin wound healing. Chapter Three summarises the evidence for the presence and role of myofibroblasts in cancer progression and discusses the similarities of myofibroblasts in cancer and fibrosis. Chapter Four focuses on the role of bone marrow stem cells and bone marrow stem cell derived myofibroblasts in carcinogenesis and cancer development, and ways to inhibit the process of malignisation.

Автор: Tsuneo Imanaka; Nobuyuki Shimozawa
Название: Peroxisomes: Biogenesis, Function, and Role in Human Disease
ISBN: 9811511683 ISBN-13(EAN): 9789811511684
Издательство: Springer
Рейтинг:
Цена: 139750.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides readers with a comprehensive overview of peroxisomes and their role in human diseases. It starts by describing the history of peroxisome research and then examines in detail the current understanding of the biogenesis and function of peroxisomes. It then focuses on peroxisomal disorders and the involvement of peroxisomes in cancer and age-related diseases, discussing in detail the use of model organisms to elucidate the pathogenesis of peroxisomal disorders and the physiological importance of peroxisomal proteins. Further, the book examines diagnostic and therapeutic strategies in peroxisomal disorders as well as significant recent advances. Lastly, it addresses various topics in peroxisome research, including the isolation of peroxisomes from mammalian tissues and cells, the structural biology of peroxisomal proteins, the lipidomics of peroxisomal disorders, the value of exome sequencing, and neuropsychological testing in X-linked adrenoleukodystrophy. Given its scope, the book is a valuable resource for postgraduate students and researchers in the life sciences and clinicians in the fields of internal medicine, pediatrics, and neurology.

Автор: Dominique Bagnard
Название: Neuropilin
ISBN: 146134932X ISBN-13(EAN): 9781461349327
Издательство: Springer
Рейтинг:
Цена: 139750.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cell adhesion is one of the most important properties controlling embryonic development. The identifica- tion of several families of adhesion molecules, well conserved throughout evolu- tion, has been the basis of a considerable amount of work over the past 20 years that contributed to establish functions of cell adhesion in almost all organs.

Автор: Cameron Wagner
Название: Endoplasmic Reticulum Stress: Regulation, Function & Role in Health & Disease
ISBN: 1634855647 ISBN-13(EAN): 9781634855648
Издательство: Nova Science
Цена: 122490.00 T
Наличие на складе: Невозможна поставка.
Описание: This book provides current research on the regulation, function and role in health and disease of endoplasmic reticulum (ER) stress. The first chapter focuses on evidence that supports the role of endoplasmic reticulum stress, mitochondria-associated membranes (MAMs) microdomain and oxidative stress during obesity as a molecular pathway to type 2 diabetes mellitus (T2DM) development. Also, it addresses protein missfolding and mitochondria function as potential targets to improve metabolic derangements in obesity and T2DM. Chapter Two summarizes and discusses the current understanding of molecular mechanisms linking ER stress to beta cell fate. Chapter Three depicts the association between eIF2α kinase-linked pathways and diet-linked pathogenic responses (such as ones caused by microbes or nutritional abnormalities). Chapter Four reviews placental endoplasmic reticulum stress in the determination of pregnancy outcome. The last chapter discusses the role of ER stress in meditating the anticancer effects of tocotrienols.