The Tumor Microenvironment: Methods and Protocols, Ursini-Siegel Josie, Beauchemin Nicole
Автор: Ursini-Siegel Название: The Tumor Microenvironment ISBN: 1493937995 ISBN-13(EAN): 9781493937998 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book covers core and emerging in vitro and in vivo protocols used to study how various components of the tumor microenvironment are established and subsequently interact with tumor cells to facilitate carcinogenesis. In addition, the book examines research topics including cellular and molecular biology approaches, in vivo genetic approaches, various “omics”-based strategies, therapeutic strategies to target the microenvironment, and, finally, advanced techniques in the fields of tissue engineering and nanotechnology. Written and validated in the laboratories of a number of trusted collaborating authors for the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Practical and authoritative, The Tumor Microenvironment: Methods and Protocols constitutes a compendium of techniques now available to a broad audience, including basic and clinician scientists, systems biologists, and biological engineers.
Автор: Koumenis Constantinos, Coussens Lisa M., Giaccia Amato Название: Tumor Microenvironment: Study Protocols ISBN: 3319799932 ISBN-13(EAN): 9783319799933 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume covers the topics presented at the 3rd International Conference on Tumor Microenvironment and Cellular Stress by an international community of researchers.
Автор: Birbrair Alexander Название: Tumor Microenvironment: Molecular Players - Part a ISBN: 3030430928 ISBN-13(EAN): 9783030430924 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including Cathepsin D, galectins, iron, oxygen, Phospholipase D1, leptin, extracellular vesicles, and more.
Автор: Matsumura Yasuhiro, Tarin David Название: Cancer Drug Delivery Systems Based on the Tumor Microenvironment ISBN: 4431568786 ISBN-13(EAN): 9784431568780 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology.
Автор: Birbrair Alexander Название: Tumor Microenvironment: Non-Hematopoietic Cells ISBN: 3030371832 ISBN-13(EAN): 9783030371838 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on non-hematopoietic cells within the tumor microenvironment.Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development.
Автор: Pawel Kalinski Название: Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy ISBN: 3319884506 ISBN-13(EAN): 9783319884509 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics.
Автор: Aref Amir R., Barbie David Название: Ex Vivo Engineering of the Tumor Microenvironment ISBN: 3319832824 ISBN-13(EAN): 9783319832821 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume will outline how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo.
1 The genomic complexity of osteosarcoma and its implication for preclinical and clinical targeted therapies
2 Genomics and the Immune Landscape of Osteosarcoma
3 RECQ DNA Helicases and Osteosarcoma
4 Targeting the Cancer Epigenome with Histone Deacetylase Inhibitors in Osteosarcoma
5 Oncolytic viruses and their potential as a therapeutic opportunity in Osteosarcoma
6 Applying Osteosarcoma Immunology to Understand Disease Progression and Assess immunotherapeutic Response
7 Targetable intercellular signaling pathways facilitate lung colonization in osteosarcoma
8 Wnt Signaling in Osteosarcoma
9 Receptor Tyrosine Kinases in Osteosarcoma: 2019 update
10 The Role of ALDH in the Metastatic Potential of Osteosarcoma Cells and Potential ALDH Targets
11 Autophagy in OS
12 Fas signaling as a potential target for the treatment of osteosarcoma metastasis in the lungs
13 Exosomes: Dynamic Mediators of Extracellular Communication in the Tumor Microenvironment
14 Comparative Immunology and Immunotherapy of Canine Osteosarcoma
Index
Автор: Birbrair Alexander Название: Tumor Microenvironment: The Role of Interleukins - Part a ISBN: 3030383148 ISBN-13(EAN): 9783030383145 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of interleukins in the tumor microenvironment.
Автор: Rejniak Название: Systems Biology of Tumor Microenvironment ISBN: 3319420216 ISBN-13(EAN): 9783319420219 Издательство: Springer Рейтинг: Цена: 148020.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics covered in this book include the quantitative image analysis of a tumor microenvironment, the microenvironmental barriers in oxygen and drug delivery to tumors, the development of tumor microenvironmental niches and sanctuaries, intravenous transport of the circulating tumor cells, the role of the tumor microenvironment in chemotherapeutic interventions, the interactions between tumor cells, the extracellular matrix, the interstitial fluid, and the immune and stromal cells. Mathematical models discussed here embrace both continuous and agent-based approaches, as well as mathematical frameworks of solid mechanics, fluid dynamics and optimal control theory. The topics in each chapter will be of interest to a biological community wishing to apply the mathematical methods to interpret their experimental data, and to a biomathematical audience interested in exploring how mathematical models can be used to address complex questions in cancer biology.
Автор: Domenico Ribatti Название: The Role of Microenvironment in the Control of Tumor Angiogenesis ISBN: 3319278185 ISBN-13(EAN): 9783319278186 Издательство: Springer Рейтинг: Цена: 121890.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Prelims
1. Tumor microenvironment
1.1. Metastatic cascade
1.2. Epithelial-mesenchymal transition
1.3. The extracellular matrix
2. Tumor blood vessels and tumor endothelial cells
2.1. Tumor basement membrane
2.2. Tumor pericytes
3. Tumor angiogenesis
3.1. Sprouting angiogenesis
3.2. Vascular co-option
3.3. Vasculogenic mimicry
3.4. Intussusceptive microvascular growth
4. Inflammatory cells in tumor microenvironment
4.1. Neutrophils
4.2. Eosinophils and dendritic cells
4.3. Lymphocytes and platelets
4.4. Mast cells
4.5. Macrophages
4.6. Tie-2 expressing monocytes (TEMs)
4.7. Fibroblasts
4.8. Osteoblasts and osteoclasts
4.9. Cancer stem cells (CSCs)
4.10.Circulating endothelial cells and endothelial precursor cells
5. Therapeutic strategies, the concept of "normalization" and the role of VEGF inhibition
Index
Автор: Birbrair Alexander Название: Tumor Microenvironment: Extracellular Matrix Components - Part B ISBN: 3030484564 ISBN-13(EAN): 9783030484569 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor microenvironment during cancer development.
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