Tumor Microenvironment: Non-Hematopoietic Cells, Birbrair Alexander
Автор: Birbrair Alexander Название: Tumor Microenvironment: Hematopoietic Cells - Part a ISBN: 3030357228 ISBN-13(EAN): 9783030357221 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Revealing essential roles of the tumor microenvironment in cancer progression, this book focuses on the role of hematopoietic components of the tumor microenvironment.
Автор: Ursini-Siegel Название: The Tumor Microenvironment ISBN: 1493937995 ISBN-13(EAN): 9781493937998 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book covers core and emerging in vitro and in vivo protocols used to study how various components of the tumor microenvironment are established and subsequently interact with tumor cells to facilitate carcinogenesis. In addition, the book examines research topics including cellular and molecular biology approaches, in vivo genetic approaches, various “omics”-based strategies, therapeutic strategies to target the microenvironment, and, finally, advanced techniques in the fields of tissue engineering and nanotechnology. Written and validated in the laboratories of a number of trusted collaborating authors for the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Practical and authoritative, The Tumor Microenvironment: Methods and Protocols constitutes a compendium of techniques now available to a broad audience, including basic and clinician scientists, systems biologists, and biological engineers.
Автор: Constantinos Koumenis; Ester Hammond; Amato Giacci Название: Tumor Microenvironment and Cellular Stress ISBN: 1493947052 ISBN-13(EAN): 9781493947058 Издательство: Springer Рейтинг: Цена: 156720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012.
Автор: Yefenof Название: Innate and Adaptive Immunity in the Tumor Microenvironment ISBN: 9048177138 ISBN-13(EAN): 9789048177134 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host.
Автор: Lee Название: Tumor Microenvironment ISBN: 3030388611 ISBN-13(EAN): 9783030388614 Издательство: Springer Рейтинг: Цена: 74530.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types.
The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers.
Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.
Автор: Serpa Jacinta Название: Tumor Microenvironment: The Main Driver of Metabolic Adaptation ISBN: 3030340244 ISBN-13(EAN): 9783030340247 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Поставка под заказ. Описание: Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics.In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells.
Автор: Kalinski Название: Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy ISBN: 3319675753 ISBN-13(EAN): 9783319675756 Издательство: Springer Рейтинг: Цена: 167700.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.
1 The genomic complexity of osteosarcoma and its implication for preclinical and clinical targeted therapies
2 Genomics and the Immune Landscape of Osteosarcoma
3 RECQ DNA Helicases and Osteosarcoma
4 Targeting the Cancer Epigenome with Histone Deacetylase Inhibitors in Osteosarcoma
5 Oncolytic viruses and their potential as a therapeutic opportunity in Osteosarcoma
6 Applying Osteosarcoma Immunology to Understand Disease Progression and Assess immunotherapeutic Response
7 Targetable intercellular signaling pathways facilitate lung colonization in osteosarcoma
8 Wnt Signaling in Osteosarcoma
9 Receptor Tyrosine Kinases in Osteosarcoma: 2019 update
10 The Role of ALDH in the Metastatic Potential of Osteosarcoma Cells and Potential ALDH Targets
11 Autophagy in OS
12 Fas signaling as a potential target for the treatment of osteosarcoma metastasis in the lungs
13 Exosomes: Dynamic Mediators of Extracellular Communication in the Tumor Microenvironment
14 Comparative Immunology and Immunotherapy of Canine Osteosarcoma
Index
Автор: Aref Amir R., Barbie David Название: Ex Vivo Engineering of the Tumor Microenvironment ISBN: 3319832824 ISBN-13(EAN): 9783319832821 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume will outline how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo.
Автор: Birbrair Alexander Название: Tumor Microenvironment: The Role of Chemokines - Part a ISBN: 3030366669 ISBN-13(EAN): 9783030366667 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of chemokines in the tumor microenvironment.
Автор: Koumenis Constantinos, Coussens Lisa M., Giaccia Amato Название: Tumor Microenvironment: Study Protocols ISBN: 3319799932 ISBN-13(EAN): 9783319799933 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume covers the topics presented at the 3rd International Conference on Tumor Microenvironment and Cellular Stress by an international community of researchers.
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