Tumor Microenvironment: The Role of Interleukins - Part a, Birbrair Alexander
Автор: Domenico Ribatti Название: The Role of Microenvironment in the Control of Tumor Angiogenesis ISBN: 3319278185 ISBN-13(EAN): 9783319278186 Издательство: Springer Рейтинг: Цена: 121890.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Prelims
1. Tumor microenvironment
1.1. Metastatic cascade
1.2. Epithelial-mesenchymal transition
1.3. The extracellular matrix
2. Tumor blood vessels and tumor endothelial cells
2.1. Tumor basement membrane
2.2. Tumor pericytes
3. Tumor angiogenesis
3.1. Sprouting angiogenesis
3.2. Vascular co-option
3.3. Vasculogenic mimicry
3.4. Intussusceptive microvascular growth
4. Inflammatory cells in tumor microenvironment
4.1. Neutrophils
4.2. Eosinophils and dendritic cells
4.3. Lymphocytes and platelets
4.4. Mast cells
4.5. Macrophages
4.6. Tie-2 expressing monocytes (TEMs)
4.7. Fibroblasts
4.8. Osteoblasts and osteoclasts
4.9. Cancer stem cells (CSCs)
4.10.Circulating endothelial cells and endothelial precursor cells
5. Therapeutic strategies, the concept of "normalization" and the role of VEGF inhibition
Index
Автор: Constantinos Koumenis; Ester Hammond; Amato Giacci Название: Tumor Microenvironment and Cellular Stress ISBN: 1461459141 ISBN-13(EAN): 9781461459149 Издательство: Springer Рейтинг: Цена: 191560.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Constitutes proceeding that discusses different cellular and animal models of TME study and identifies common pathways that are candidates for therapeutic intervention, stimulate collaboration between groups that are focused on elucidation of biochemical aspects of stress biology and groups that study pathophysiological aspects of stress pathways.
Автор: Ursini-Siegel Название: The Tumor Microenvironment ISBN: 1493937995 ISBN-13(EAN): 9781493937998 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book covers core and emerging in vitro and in vivo protocols used to study how various components of the tumor microenvironment are established and subsequently interact with tumor cells to facilitate carcinogenesis. In addition, the book examines research topics including cellular and molecular biology approaches, in vivo genetic approaches, various “omics”-based strategies, therapeutic strategies to target the microenvironment, and, finally, advanced techniques in the fields of tissue engineering and nanotechnology. Written and validated in the laboratories of a number of trusted collaborating authors for the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Practical and authoritative, The Tumor Microenvironment: Methods and Protocols constitutes a compendium of techniques now available to a broad audience, including basic and clinician scientists, systems biologists, and biological engineers.
Автор: Birbrair Alexander Название: Tumor Microenvironment: The Role of Chemokines - Part a ISBN: 3030366669 ISBN-13(EAN): 9783030366667 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of chemokines in the tumor microenvironment.
Автор: Birbrair Alexander Название: Tumor Microenvironment: Extracellular Matrix Components - Part a ISBN: 3030401456 ISBN-13(EAN): 9783030401450 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor during cancer development.
Автор: Birbrair Alexander Название: Tumor Microenvironment: Extracellular Matrix Components - Part B ISBN: 3030484564 ISBN-13(EAN): 9783030484569 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor microenvironment during cancer development.
Автор: Birbrair Alexander Название: Tumor Microenvironment: Hematopoietic Cells - Part a ISBN: 3030357228 ISBN-13(EAN): 9783030357221 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Revealing essential roles of the tumor microenvironment in cancer progression, this book focuses on the role of hematopoietic components of the tumor microenvironment.
Автор: Ribatti Domenico Название: The Role of Microenvironment in the Control of Tumor Angiogenesis ISBN: 3319802224 ISBN-13(EAN): 9783319802220 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This work describes the importance of tumor microenvironment in favouring tumor progression and angiogenesis. Under physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the vascular microenvironment and requires the functional activities of a number of molecules, including angiogenic factors, extracellular matrix proteins, adhesion molecules and proteolytic enzymes. In normal tissues, vascular quiescence is maintained by the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli. Tumor angiogenesis is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic cells of specific growth factors for endothelial cells, that stimulate the growth of the blood vessels of the host or the down-regulation of natural angiogenesis inhibitors. In particular, the inflammatory infiltrate may contribute to tumor angiogenesis, and there are many reports of associations between tumor inflammatory infiltrate, vascularity and prognosis. New therapeutic approaches have been developed with the aim to control tumor angiogenesis through targeting of different components of tumor microenvironment.
Автор: Birbrair Alexander Название: Tumor Microenvironment: Signaling Pathways - Part a ISBN: 3030355810 ISBN-13(EAN): 9783030355814 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment.
Автор: Birbrair Alexander Название: Tumor Microenvironment: Molecular Players - Part a ISBN: 3030430928 ISBN-13(EAN): 9783030430924 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including Cathepsin D, galectins, iron, oxygen, Phospholipase D1, leptin, extracellular vesicles, and more.
Автор: Birbrair Alexander Название: Tumor Microenvironment: State of the Science ISBN: 3030445178 ISBN-13(EAN): 9783030445171 Издательство: Springer Рейтинг: Цена: 167700.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: A variety of topics are covered, including metabolism in the tumor microenvironment, stellate cells and endothelial progenitors in the tumor microenvironment, as well as the effects of HIV, viral hepatitis, and inflammation in the tumor microenvironment, and more.
Автор: Aref Название: Ex Vivo Engineering of the Tumor Microenvironment ISBN: 3319453955 ISBN-13(EAN): 9783319453958 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume will outline how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo. Much of what may be learned from this volume will aid in understanding many aspects of the enhanced study of tumor cell biology in a physiologic context, open new avenues for drug screening and biomarker development, and accelerate the preclinical evaluation of novel personalized medicine strategies for patients in real time.
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