Pharmacokinetic Principles of Dosing Adjustments, Schoenwald, Ronald D.
Автор: Randall J. Mrsny, Ann Daugherty Название: Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes ISBN: 1420078062 ISBN-13(EAN): 9781420078060 Издательство: Taylor&Francis Рейтинг: Цена: 128620.00 T Наличие на складе: Есть Описание: Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is an invaluable source for drug discovery and development scientists in the biopharmaceutical industry who frequently navigate the maze of protein and peptide pharmacokinetics, pharmacodynamics, and metabolism.
Key features include:
issues related to delivery of protein and peptide therapeutics in elderly populations and pharmacogenomics
lessons learned on the major marketed areas of proteins and peptides, including interleukins, interferons, growth factors, and peptide hormones
innovations for protein and peptide delivery such as needle-less delivery
strategies for delivery of these molecules to locations such as the eye and brain
Автор: Peter L. Bonate Название: Pharmacokinetic-Pharmacodynamic Modeling and Simulation ISBN: 1489973869 ISBN-13(EAN): 9781489973863 Издательство: Springer Рейтинг: Цена: 153720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation.
Автор: Strauss Название: Mathematical Modeling of Pharmacokinetic Data ISBN: 1566762049 ISBN-13(EAN): 9781566762045 Издательство: Taylor&Francis Рейтинг: Цена: 255200.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: A guide to mathematical modeling and analysis of pharmacokinetic data. It covers methods for maximizing the information obtained from given data. It presents an approach to using the mathematical software tools available so that the investigator may extract the maximum information from a given set of data.
Название: Handbook of Pharmacokinetic/Pharmacodynamic Correlation ISBN: 0367228033 ISBN-13(EAN): 9780367228033 Издательство: Taylor&Francis Рейтинг: Цена: 153120.00 T Наличие на складе: Поставка под заказ. Описание: This book provides a holistic representation of developments and patterns of mergers and acquisitions that have taken place in the Indian corporate sector especially in the post-liberalisation era. It also gives an overview of competitive strategies and performance of Indian industries under globalisation relating it with the specific characteristics of firms that engaged in overseas acquisitions.
Автор: David B. Jack Название: Handbook of Clinical Pharmacokinetic Data ISBN: 1349224979 ISBN-13(EAN): 9781349224975 Издательство: Springer Рейтинг: Цена: 78350.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This compendium of essential drug data helps when planning clinical research projects and choosing drugs with specific properties. As well as covering established drugs, data is presented on compounds about to be marketed or in the last stages of clinical development.
Автор: Bernard Testa Название: Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies ISBN: 3906390225 ISBN-13(EAN): 9783906390222 Издательство: Wiley Рейтинг: Цена: 153120.00 T Наличие на складе: Невозможна поставка. Описание: In this age of combinatorial chemistry and high-throughput technologies, bioactive compounds called hits are discovered by the thousands. However, the road that leads from hits to lead compounds and then to pharmacokinetically optimized clinical and drug candidates is very long indeed. As a result, the screening, design, and optimization of pharmacokinetic properties has become the bottleneck and a major challenge in drug research. To shorten the time-consuming develop-ment and high rate of attrition of active compounds ultimately doomed by hidden pharmacokinetic defects, drug researchers are coming to incorporate structure-permeation, structure-distribution, structure-metabolism, and structure-toxicity relations into drug-design strategies. To this end, powerful biological, physicochemical, and computational approaches are being developed whose objectives are to increase the clinical relevance of drug design, and to eliminate as soon as possible compounds with unfavorable physicochemical properties and pharmacokinetic profiles. Toxicological issues are also of utmost importance in this paradigm. There was, hence, an urgent need for a book covering this field in an authoritative, didactic, comprehensive, factual, and conceptual manner. In this work of unique breadth and depth, international authorities and practicing experts from academia and industry present the most modern biological, physicochemical, and computational strategies to optimize gastrointestinal absorption, protein binding and distribution, brain permeation, and metabolic profile. The biological strategies emphasized in the book include cell cultures and high-throughput screens. The physicochemical strategies focus on the determination and interpretation of solubility, lipophilicity, and related molecular properties as factors and predictors of pharmacokinetic bahavior. Particular attention is paid to the lipophilicity profiles of ionized compounds, to lipophicity measurements in anisotropic media (liposomes/water, IAM columns), and to permeability across artificial membranes. Computational strategies comprise virtual screening, molecular modelling, lipophilicity, and H-bonding fields and their importance for structure-disposition relations. This book is both about theoretical and technological breakthroughs. Thus, molecular properties are contemplated from a dual perspective, namely a) their interpretation in biological and/or physicochemical terms, and b) their value in screening, lead optimization, and drug-candidate selection. In addition to its 33 chapters, the book includes a CD-ROM containing the invited lectures, oral communications and posters (in full version) presented at the Second LogP Symposium, 'Lipophilicity in Drug Disposition -- Practical and Computational Approaches to Molecular Properties Related to Drug Permeation, Disposition and Metabolism', held at the University of Lausanne in March 2000.
Автор: David D`Argenio Название: Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis ISBN: 0306440288 ISBN-13(EAN): 9780306440281 Издательство: Springer Рейтинг: Цена: 174130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of the 1990 Biomedical Simulations Resource Workshop, held in Marina del Rey, California, May 18-19, 1990
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