Handbook of Clinical Pharmacokinetic Data, David B. Jack

Автор: Bauer
Название: Handbook of clinical pharmacokinetics
ISBN: 007142542X ISBN-13(EAN): 9780071425421
Издательство: McGraw-Hill
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Цена: 42310.00 T
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Описание: Designed for pharmacists and clinicians responsible for adjusting drug dosages based on the patient blood serum concentrations and other parameters, this indispensable, portable reference offers a variety of ways to perform pharmacokinetic calculations. It also features calculation methods, algorithms for choosing the best calculation method, and case studies.

Автор: Alexander Vinks; Hartmut Derendorf; Johan Mouton (
Название: Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics
ISBN: 0387756124 ISBN-13(EAN): 9780387756127
Издательство: Springer
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Цена: 158380.00 T
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Описание: The reader will be introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, and the translation of in vitro and animal model data to basic research and clinical situations in humans.

Автор: Kimko Hui
Название: Simulation For Designing Clinical Trials: A Pharmacokinetic-Pharmacodynamic Modeling Perspective
ISBN: 0824708628 ISBN-13(EAN): 9780824708627
Издательство: Taylor&Francis
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Цена: 183750.00 T
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Описание: Providing more than just a comprehensive history, critical vocabulary, insightful compilation of motivations, and clear explanation of the state-of-the-art of modern clinical trial simulation, this book supplies a rigorous framework for employing simulation as an experiment, according to a predefined simulation plan, that reflects good simulation practices. The book discusses how to design clinical trials according to their probability for success, techniques to define distributions of virtual subjects' characteristics, methods to determine the sensitivity of the trial design, and the population relationship between dosing schedules and patient response.

Автор: Tony K.L. Kiang; Kyle John Wilby; Mary H.H. Ensom
Название: Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials
ISBN: 3319381938 ISBN-13(EAN): 9783319381930
Издательство: Springer
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Цена: 55890.00 T
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Описание: Introduction.- Pharmacology of Recommended Antimalarial Agents.- Drug Interaction Potential of Antimalarial Drugs Based on Known Metabolic Properties of Antimalarials.- Pharmacokinetic Drug Interactions Affecting Antimalarials.- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Drugs.- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Antimalarials.- Pharmacodynamic Interactions: Clinical Evidence for Combination Therapy, In Vitro Interactions, and In Vivo Interactions.- Limitations, Future Directions, and Conclusions.

Автор: Tony K.L. Kiang; Kyle John Wilby; Mary H.H. Ensom
Название: Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials
ISBN: 3319105264 ISBN-13(EAN): 9783319105260
Издательство: Springer
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Цена: 60550.00 T
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Описание: This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested.  In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (i.e. chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs.

Автор: David D`Argenio
Название: Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis
ISBN: 1475790236 ISBN-13(EAN): 9781475790238
Издательство: Springer
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Цена: 121890.00 T
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Описание: Proceedings of the 1990 Biomedical Simulations Resource Workshop, held in Marina del Rey, California, May 18-19, 1990

Автор: O. Pelkonen; A. Baumann; A. Reichel
Название: Pharmacokinetic Challenges in Drug Discovery
ISBN: 3662043858 ISBN-13(EAN): 9783662043851
Издательство: Springer
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Цена: 158380.00 T
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Описание: The Pharmaceutical industry is therefore focussing on ways to reduce attrition by addressing frequent reasons for clinical drug failures very early in the drug discovery process.

Автор: David D`Argenio
Название: Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis
ISBN: 0306440288 ISBN-13(EAN): 9780306440281
Издательство: Springer
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Цена: 174130.00 T
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Описание: Proceedings of the 1990 Biomedical Simulations Resource Workshop, held in Marina del Rey, California, May 18-19, 1990

Автор: Bernard Testa
Название: Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies
ISBN: 3906390357 ISBN-13(EAN): 9783906390352
Издательство: Wiley
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Цена: 239660.00 T
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Описание: Informatics and robotics are the workhorses of a technological revolution in drug research. On them are based combinatorial chemistry, which yields compounds by the many thousands, and high-throughput bioassays, which screen them for activity. The results are avalanches of `hits`, which invade the databases like swarms of locusts.

Автор: Peter L. Bonate
Название: Pharmacokinetic-Pharmacodynamic Modeling and Simulation
ISBN: 1489973869 ISBN-13(EAN): 9781489973863
Издательство: Springer
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Цена: 153720.00 T
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Описание: The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation.

Автор: David D`Argenio
Название: Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis
ISBN: 0306450186 ISBN-13(EAN): 9780306450181
Издательство: Springer
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Цена: 174150.00 T
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Описание: Proceedings of the 1993 Biomedical Simulations Research Workshop, held in Los Angeles, California, May 21-22, 1993

Автор: Andrew A. Udy; Jason A. Roberts; Jeffrey Lipman
Название: Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill
ISBN: 9811053359 ISBN-13(EAN): 9789811053351
Издательство: Springer
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Цена: 111790.00 T
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Описание: This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill.