Pharmacokinetic-Pharmacodynamic Modeling and Simulation, Peter L. Bonate

Автор: Alexander Vinks; Hartmut Derendorf; Johan Mouton (
Название: Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics
ISBN: 0387756124 ISBN-13(EAN): 9780387756127
Издательство: Springer
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Цена: 158380.00 T
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Описание: The reader will be introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, and the translation of in vitro and animal model data to basic research and clinical situations in humans.

Автор: David D`Argenio
Название: Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis
ISBN: 0306440288 ISBN-13(EAN): 9780306440281
Издательство: Springer
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Цена: 174130.00 T
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Описание: Proceedings of the 1990 Biomedical Simulations Resource Workshop, held in Marina del Rey, California, May 18-19, 1990

Автор: Andrew A. Udy; Jason A. Roberts; Jeffrey Lipman
Название: Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill
ISBN: 9811053359 ISBN-13(EAN): 9789811053351
Издательство: Springer
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Описание: This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill.

Автор: Burton
Название: Applied Pharmacokinetics and Pharmacodynamics
ISBN: 0781744318 ISBN-13(EAN): 9780781744317
Издательство: Lippincott Williams & Wilkins
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Цена: 51480.00 T
Наличие на складе: Невозможна поставка.
Описание: "The definitive advanced-level clinical pharmacokinetics text is now in its Fourth Edition, with new emphasis on the relationship between pharmacokinetics and pharmacodynamics. Written by 70 leading researchers and practitioners, this book is a rigorous yet practical text on the application of pharmacokinetic methods, pharmacodynamic principles, and pharmacotherapeutic data for optimal, individualized drug therapy.

Автор: Macheras Panos, Iliadis Athanassios
Название: Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics / Homogeneous and Heterogeneous Approaches
ISBN: 0387281789 ISBN-13(EAN): 9780387281780
Издательство: Springer
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Цена: 55850.00 T
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Описание: The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with empirical, compartmental, and stochastic pharmacokinetic models, and the fourth mainly with nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods. The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with empirical, compartmental, and stochastic pharmacokinetic models, and the fourth mainly with nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods. www.springeronline.com

Автор: Kimko Hui
Название: Simulation For Designing Clinical Trials: A Pharmacokinetic-Pharmacodynamic Modeling Perspective
ISBN: 0824708628 ISBN-13(EAN): 9780824708627
Издательство: Taylor&Francis
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Цена: 183750.00 T
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Описание: Providing more than just a comprehensive history, critical vocabulary, insightful compilation of motivations, and clear explanation of the state-of-the-art of modern clinical trial simulation, this book supplies a rigorous framework for employing simulation as an experiment, according to a predefined simulation plan, that reflects good simulation practices. The book discusses how to design clinical trials according to their probability for success, techniques to define distributions of virtual subjects' characteristics, methods to determine the sensitivity of the trial design, and the population relationship between dosing schedules and patient response.

Автор: Bonate
Название: Pharmacokinetic-Pharmacodynamic Modeling and Simulation
ISBN: 038727197X ISBN-13(EAN): 9780387271972
Издательство: Springer
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Цена: 62380.00 T
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Описание: A natural hierarchy exists in pharmacokinetic-pharmacodynamic modeling culminating in population pharmacokinetic models, which are a specific type of nonlinear mixed effects model. The purpose of this book is to present through theory and example how to develop pharmacokinetic models, both at an individual and population level. In order to do so, however, one must first understand linear models and then build to nonlinear models followed by linear mixed effects models and then ultimately nonlinear mixed effects models. This book develops in that manner – each chapter builds upon previous chapters by first presenting the theory and then illustrating the theory using published data sets and actual data sets that were used in the development of new chemical entities collected by the author during his years in industry. A key feature of the book is the process of modeling. Most books and manuscripts often present the final model never showing how the model evolved. In this book all examples are presented in an evolutionary manner.

Автор: David D`Argenio
Название: Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis
ISBN: 1475790236 ISBN-13(EAN): 9781475790238
Издательство: Springer
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Цена: 121890.00 T
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Описание: Proceedings of the 1990 Biomedical Simulations Resource Workshop, held in Marina del Rey, California, May 18-19, 1990

Автор: David D`Argenio
Название: Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis
ISBN: 0306450186 ISBN-13(EAN): 9780306450181
Издательство: Springer
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Цена: 174150.00 T
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Описание: Proceedings of the 1993 Biomedical Simulations Research Workshop, held in Los Angeles, California, May 21-22, 1993

Автор: David D`Argenio
Название: Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis
ISBN: 1475785623 ISBN-13(EAN): 9781475785623
Издательство: Springer
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Цена: 214280.00 T
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Описание: Advanced Methods of Pharmacokinetic and Pharmocodynamic Systems Analysis Volume 3 is vital to professionals and academicians working in drug development and bioengineering.

Автор: Tony K.L. Kiang; Kyle John Wilby; Mary H.H. Ensom
Название: Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials
ISBN: 3319381938 ISBN-13(EAN): 9783319381930
Издательство: Springer
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Цена: 55890.00 T
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Описание: Introduction.- Pharmacology of Recommended Antimalarial Agents.- Drug Interaction Potential of Antimalarial Drugs Based on Known Metabolic Properties of Antimalarials.- Pharmacokinetic Drug Interactions Affecting Antimalarials.- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Drugs.- Effects of Antimalarials on the Pharmacokinetics of Co-Administered Antimalarials.- Pharmacodynamic Interactions: Clinical Evidence for Combination Therapy, In Vitro Interactions, and In Vivo Interactions.- Limitations, Future Directions, and Conclusions.

Автор: Tony K.L. Kiang; Kyle John Wilby; Mary H.H. Ensom
Название: Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials
ISBN: 3319105264 ISBN-13(EAN): 9783319105260
Издательство: Springer
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Цена: 60550.00 T
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Описание: This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested.  In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (i.e. chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs.