Pharmacokinetics for the Pharmaceutical Scientist, Wagner, John G.
Автор: Wagner Название: Pharmacokinetics for the Pharmaceutical Scientist ISBN: 1566760321 ISBN-13(EAN): 9781566760324 Издательство: Taylor&Francis Рейтинг: Цена: 265410.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: A major presentation of pharmacokinetics by a leading international expert, this is a complete book on modeling the pharmacokinetics of drugs.
Автор: Thorsteinn Loftsson Название: Essential Pharmacokinetics ISBN: 0128014113 ISBN-13(EAN): 9780128014110 Издательство: Elsevier Science Рейтинг: Цена: 59890.00 T Наличие на складе: Поставка под заказ. Описание: Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences. This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource. Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more. Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients.
Автор: Derendorf Название: Rowland and Tozer`s Clinical Pharmacokinetics and Pharmacodynamics: ISBN: 1496385047 ISBN-13(EAN): 9781496385048 Издательство: Lippincott Williams & Wilkins Рейтинг: Цена: 97240.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Updated with the latest clinical advances, Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition, explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.
Key updates reflect advances in PK/PD as related to clinical decision making and drug research and development.
An emphasis on the clinical relevance of drugs makes the book especially applicable to pharmacy students preparing for a career in clinical practice.
Hundreds of graphs and tables provide visual representations of key pharmacokinetic/pharmacodynamic principles and effects.
More than 200 carefully written study questions, with answers and in-depth explanations, help readers enhance their conceptual understanding and learn and retain key information.
New and updated examples connect chapter content to real-world settings.
Interactive online simulations give students practice using different pharmacokinetic/pharmacodynamic models and parameters.
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Автор: Hedaya Mohsen A. Название: Basic Pharmacokinetics, Second Edition ISBN: 1439850739 ISBN-13(EAN): 9781439850732 Издательство: Taylor&Francis Рейтинг: Цена: 102070.00 T Наличие на складе: Нет в наличии. Описание: Knowledge of pharmacokinetics is critical to understanding the absorption, distribution, metabolism, and excretion of drugs. Accessible to a wide variety of readers, this volume demonstrates the quantitative pharmacokinetic relations and the interplay between pharmacokinetic parameters. Accompanying the book are downloadable resources with self-
Автор: Bauer Название: Applied Clinical Pharmacokinetics ISBN: 0071794581 ISBN-13(EAN): 9780071794589 Издательство: McGraw-Hill Рейтинг: Цена: 84650.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Helps you learn the clinical application of pharmacokinetics. This book delivers clear and clinically relevant coverage of drug dosing and drug monitoring that no other text can match. It offers the standardized techniques and approaches to patient-specific dosing, and information on pharmacokinetically monitored drugs.
Название: Drug Metabolism, Pharmacokinetics and Bioanalysis ISBN: 3038979163 ISBN-13(EAN): 9783038979166 Издательство: Неизвестно Рейтинг: Цена: 62730.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug-drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.
Автор: Andrea Angelini Название: Voriconazole: Pharmacokinetics, Role in Therapeutic Drug Monitoring & Clinical Outcomes ISBN: 163463313X ISBN-13(EAN): 9781634633130 Издательство: Nova Science Рейтинг: Цена: 224920.00 T Наличие на складе: Невозможна поставка. Описание: In the last twenty years, the incidence of invasive fungal infections (IFI) has risen dramatically due to the prolongation of survival of patients with multiple risk factors for fungal infections and due to the increase of infection associated with travel. Moreover IFI in infants admitted to the neonatal intensive care unit are common and often fatal. Amphotericin B was for more than 40 years the gold standard for almost all IFI, but toxicity and resistance, especially of new and emerging pathogens remained important issues. Fluconazole and itraconazole have also the same disadvantage of resistance. After a long period of relative inactivity in the introduction of new antifungals, more recently a few new drugs of already existing classes have been introduced as important agents in the treatment and prevention of IFI. These represent small or large advantages and differences compared with existing available alternative therapy for deep and systemic mycoses. Voriconazole is a second-generation triazole antifungal drug, often prescribed as first-line therapy for candidemia, in non-neutropenic hosts, for invasive pulmonary aspergillosis and as prophylaxis of many systemic mycoses. In-vitro and in-vivo studies showed that voriconazole has broad-spectrum activity against most Candida species, Aspergillus species, fusariosis or scedosporiosis. Voriconazole has non-linear pharmacokinetics and, as substrate and inhibitor of cytochrome P450, it undergoes extensive hepatic metabolism that depends on age, genetic factors, and interactions with other drugs, which may lead to enhanced toxicity of the concomitant medication(s) or ineffective antifungal treatment. This book presents an update on voriconazole research, particularly its pharmacology, microbiology, toxicology, and clinical outcomes in order to optimize its use in daily clinical practice.
Автор: T. Teorell Название: Pharmacology and Pharmacokinetics ISBN: 1468420577 ISBN-13(EAN): 9781468420579 Издательство: Springer Рейтинг: Цена: 113190.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: As one of the founders of pharmacokinetics, Professor Teorell has made many contributions to the field since he first presented a formal multicompartment model for the analysis of drug action and drug metabolism in 1937 (Teorell, 1937).
Автор: Rescigno Aldo Название: Foundations of Pharmacokinetics ISBN: 0306477041 ISBN-13(EAN): 9780306477041 Издательство: Springer Рейтинг: Цена: 174150.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book is divided into two parts; in the first part the principles and the methods of pharmacokinetics are described in detail, while in the second the main pharmacokinetic parameters are described, giving for each of them the definition, the principal properties, and the methods of determination. An appendix contains the important mathematical instruments used in the main part of the book, namely the operational calculus and the convolution integral. In the second part there is a careful distinction among pharmacokinetic parameters, i.e., parameters that represent a true pharmacokinetic property, model parameters, i.e., parameters that represent a property of a specific model, and incidental parameters, i.e., parameters that represent only the result of a particular experiment. Special care is taken to distinguish between the definition of a parameter, and the properties that derive from that definition; a considerable emphasis is also given to the fact that each method for the determination of a parameter is dependent on the specific model it is based on.
Автор: Riviere E Jim, Wang J Paul, Sackner-Bernstein Jona Название: Comparative Pharmacokinetics ISBN: 081382138X ISBN-13(EAN): 9780813821382 Издательство: Wiley Рейтинг: Цена: 42230.00 T Наличие на складе: Невозможна поставка. Описание: Presents an overview of pharmacokinetics. This work explains the scientific data and mathematical models of the discipline within the context of biological reality. It explains and assesses both mechanistic, compartmental models, and the empirical noncompartmental models, considering strengths and weaknesses of each.
Автор: A. Pecile Название: Pharmacokinetics ISBN: 146845465X ISBN-13(EAN): 9781468454659 Издательство: Springer Рейтинг: Цена: 113190.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This unique feature of the Course is also the unique characteristic of this book which is therefore mainly directed to people interested not just in acquiring a working knowledge of the methods but in developing new methods.
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