Автор: Kaur, Harleen Название: Monoclonal Antibodies ISBN: 0128223189 ISBN-13(EAN): 9780128223185 Издательство: Elsevier Science Рейтинг: Цена: 153830.00 T Наличие на складе: Невозможна поставка. Описание:
Monoclonal antibodies (mAbs) are naturally occurring complex biomolecules. New engineering methods have turned mAbs into a leading therapeutic modality for addressing immunotherapeutic challenges and led to the rise of mAbs as the dominant class of protein therapeutics. mAbs have already demonstrated a great potential in developing safe and reliable treatments for complex diseases and creating more affordable healthcare alternatives. Developing mAbs into well-characterized antibody therapeutics that meet regulatory expectations, however, is extremely challenging. Obstacles to overcome include the determination and development of physiochemical characteristics such as aggregation, fragmentation, charge variants, identity, carbohydrate structure, and higher-order structure (HOS).
This book dives deep into mAbs structure and the array of physiochemical testing and characterization methods that need to be developed and validated to establish a mAb as a therapeutic molecule. The main focus of this book is on physiochemical aspects, including the importance of establishing quality attributes such as glycosylation, primary sequence, purity, and HOS and elucidating the structure of new antibody formats by mass spectrometry. Each of the aforementioned quality attributes has been discussed in detail; this will help scientists in researching and developing biopharmaceuticals and biosimilars to find practical solutions to physicochemical testing and characterization.
Автор: James W. Larrick; C. Borrebaeck Название: Therapeutic Monoclonal Antibodies ISBN: 1349118966 ISBN-13(EAN): 9781349118960 Издательство: Springer Рейтинг: Цена: 104480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: A review of therapeutic antibodies which have commercial potential. It discusses PCR cloning of Igs, immortalization by gene transfer, scale up production, infectious diseases, viruses, bacteria, parisites, inflammation/immunology, blood grouping, cells, cytokines, tumours and MDR.
Автор: Martin Rosenberg; R. Balint; Gordon P. Moore; C.F. Название: The Pharmacology of Monoclonal Antibodies ISBN: 3642784348 ISBN-13(EAN): 9783642784347 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This rapidly-evolving field has witnessed the PCR combinatorial cloning of vast immunological diversity, in vitro mutagenesis of MAbs, MAbs created by transgenic animals, novel expression systems in plants, animals and lower systems, as well as a rich variety of genetically modified MAbs as potential therapeutic agents.
Автор: John Landon; Tim Chard Название: Therapeutic Antibodies ISBN: 1447119398 ISBN-13(EAN): 9781447119395 Издательство: Springer Рейтинг: Цена: 95770.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Several aspects of clinical medicine are poised on the edge of a new era with the introduction of therapeutic antibodies. This volume is aimed at all clinicians involved with this form of treatment, especially accident and emergency physicians, clinical immunologists, and pharmacologists.
Автор: G. Subramanian Название: Antibodies ISBN: 0306483157 ISBN-13(EAN): 9780306483158 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Brings to the forefront the advances in novel technologies for the manufacturing of monoclonal antibodies and also their clinical importance. This volume focusses on: technologies in the manufacture of monoclonal antibodies, the application of antibodies in cancer therapy and functional genomic therapy, and the importance of antibodies.
Автор: G. Subramanian Название: Antibodies ISBN: 1461347025 ISBN-13(EAN): 9781461347026 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Both the nature of monoclonal antibody therapies and the relatively large size of the monoclonal antibody dictate the production requirements, for many ofthese therapeutics the monoclonal antibody product will be 100 kilogrammes or more per year.
Автор: Chernajovsky Название: Therapeutic Antibodies ISBN: 3540732586 ISBN-13(EAN): 9783540732587 Издательство: Springer Рейтинг: Цена: 330870.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: With contributions by numerous experts
Автор: R?diger Schade; Ingrid Behn; Michael Erhard; Andre Название: Chicken Egg Yolk Antibodies, Production and Application ISBN: 3662044900 ISBN-13(EAN): 9783662044902 Издательство: Springer Рейтинг: Цена: 87070.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Polyclonal antibodies, widely used in research and diagnostics, are conventionally isolated from the blood of immunised mammals. The fact that antibodies can also be detected in the yolk of eggs laid by immunised hens, led to the development of the yolk antibody technology as an alternative method less stressful to animals.
Автор: Antonino Cattaneo; Silvia Biocca Название: Intracellular Antibodies ISBN: 3662079941 ISBN-13(EAN): 9783662079942 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Recent advances in the field of recombinant antibodies have permitted the manipulation of genes encoding specific antibodies, thus allowing their ectopic expression in a wide variety of non-lymphoid cells.
Автор: Bob Kiss; Uwe Gottschalk; Michael Pohlscheidt Название: New Bioprocessing Strategies: Development and Manufacturing of Recombinant Antibodies and Proteins ISBN: 3319971085 ISBN-13(EAN): 9783319971087 Издательство: Springer Рейтинг: Цена: 326090.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science.Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification.In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.
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