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Monoclonal Antibodies, Kaur, Harleen


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Автор: Kaur, Harleen
Название:  Monoclonal Antibodies
ISBN: 9780128223185
Издательство: Elsevier Science
Классификация:
ISBN-10: 0128223189
Обложка/Формат: Paperback
Страницы: 225
Вес: 0.45 кг.
Дата издания: 01.08.2021
Язык: English
Размер: 152 x 224 x 18
Читательская аудитория: Professional & vocational
Подзаголовок: Physicochemical analysis
Ссылка на Издательство: Link
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Поставляется из: Европейский союз
Описание:

Monoclonal antibodies (mAbs) are naturally occurring complex biomolecules. New engineering methods have turned mAbs into a leading therapeutic modality for addressing immunotherapeutic challenges and led to the rise of mAbs as the dominant class of protein therapeutics. mAbs have already demonstrated a great potential in developing safe and reliable treatments for complex diseases and creating more affordable healthcare alternatives. Developing mAbs into well-characterized antibody therapeutics that meet regulatory expectations, however, is extremely challenging. Obstacles to overcome include the determination and development of physiochemical characteristics such as aggregation, fragmentation, charge variants, identity, carbohydrate structure, and higher-order structure (HOS).

This book dives deep into mAbs structure and the array of physiochemical testing and characterization methods that need to be developed and validated to establish a mAb as a therapeutic molecule. The main focus of this book is on physiochemical aspects, including the importance of establishing quality attributes such as glycosylation, primary sequence, purity, and HOS and elucidating the structure of new antibody formats by mass spectrometry. Each of the aforementioned quality attributes has been discussed in detail; this will help scientists in researching and developing biopharmaceuticals and biosimilars to find practical solutions to physicochemical testing and characterization.



Therapeutic Monoclonal Antibodies

Автор: James W. Larrick; C. Borrebaeck
Название: Therapeutic Monoclonal Antibodies
ISBN: 1349118966 ISBN-13(EAN): 9781349118960
Издательство: Springer
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Цена: 104480.00 T
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Описание: A review of therapeutic antibodies which have commercial potential. It discusses PCR cloning of Igs, immortalization by gene transfer, scale up production, infectious diseases, viruses, bacteria, parisites, inflammation/immunology, blood grouping, cells, cytokines, tumours and MDR.

The Pharmacology of Monoclonal Antibodies

Автор: Martin Rosenberg; R. Balint; Gordon P. Moore; C.F.
Название: The Pharmacology of Monoclonal Antibodies
ISBN: 3642784348 ISBN-13(EAN): 9783642784347
Издательство: Springer
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Цена: 121110.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This rapidly-evolving field has witnessed the PCR combinatorial cloning of vast immunological diversity, in vitro mutagenesis of MAbs, MAbs created by transgenic animals, novel expression systems in plants, animals and lower systems, as well as a rich variety of genetically modified MAbs as potential therapeutic agents.

Monoclonal Antibodies & T Cell Products

Название: Monoclonal Antibodies & T Cell Products
ISBN: 0367228351 ISBN-13(EAN): 9780367228354
Издательство: Taylor&Francis
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Цена: 153120.00 T
Наличие на складе: Нет в наличии.
Описание: "ANOTHER galaxy, another time." This was the opening line for Star Wars: From the Adventures of Luke Skywalker, first published in December 1976, six months before the movie release of Star Wars: A New Hope. This novelization was ghostwritten by Alan Dean Foster but credited to George Lucas. The book title would later be republished under the title Star Wars: A New Hope. This double-sided tee has the first edition cover art by artist Ralph McQuarrie on the front and the book description on the back. Product Details: 100% Cotton fitted tee, Distressed, softened print, colour: black. Size: Medium, Length: 28 1/2 inches, Chest: 39 1/2 inches. Each purchase helps to fund literacy programs and book donations to communities in need.

Therapeutic Antibodies

Автор: John Landon; Tim Chard
Название: Therapeutic Antibodies
ISBN: 1447119398 ISBN-13(EAN): 9781447119395
Издательство: Springer
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Цена: 95770.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Several aspects of clinical medicine are poised on the edge of a new era with the introduction of therapeutic antibodies. This volume is aimed at all clinicians involved with this form of treatment, especially accident and emergency physicians, clinical immunologists, and pharmacologists.

Antibodies

Автор: G. Subramanian
Название: Antibodies
ISBN: 1461347017 ISBN-13(EAN): 9781461347019
Издательство: Springer
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Цена: 139750.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:

If the antibody industry is to achieve its full potential in the next decade, the individual technical potentials must be exploited, the limitations must be addressed, and lessons learned must be applied both to current purification methods and to the new technologies that continue to emerge. This book presents an overview of the current advances applied in the manufacture of monoclonal antibody including:
-concepts in development of manufacturing strategies,
-importance of antibody fragments,
-application of chromatography method development,
-quality control,
-effect of expression on antibody properties,
-virus removal and safety,
-pharmacokinetics,
-regulatory aspects.

Antibodies Volume 1: Production and Purification together with Volume 2: Novel Technologies and Therapeutic Use will be of great value to all of those who are actively working in the field of antibodies.
Volume 2: Novel Technologies and Therapeutic Use brings to the forefront current advances in novel technologies for the manufacturing of monoclonal antibodies and also their extensive clinical importance. Following on from Antibodies Volume 1: Production and Purification, this volume concentrates on:
-new technologies in the manufacture of monoclonal antibodies,
-the application of antibodies in cancer therapy and functional genomic therapy,
-the importance of antibodies and prospects of antibody engineering for the future.


Antibodies

Автор: G. Subramanian
Название: Antibodies
ISBN: 1461347025 ISBN-13(EAN): 9781461347026
Издательство: Springer
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Цена: 130430.00 T
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Описание: Both the nature of monoclonal antibody therapies and the relatively large size of the monoclonal antibody dictate the production requirements, for many ofthese therapeutics the monoclonal antibody product will be 100 kilogrammes or more per year.

Antibodies

Автор: G. Subramanian
Название: Antibodies
ISBN: 0306483157 ISBN-13(EAN): 9780306483158
Издательство: Springer
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Цена: 139750.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Brings to the forefront the advances in novel technologies for the manufacturing of monoclonal antibodies and also their clinical importance. This volume focusses on: technologies in the manufacture of monoclonal antibodies, the application of antibodies in cancer therapy and functional genomic therapy, and the importance of antibodies.

Process Scale Purification of Antibodies, Second E dition

Автор: Gottschalk
Название: Process Scale Purification of Antibodies, Second E dition
ISBN: 1119126916 ISBN-13(EAN): 9781119126911
Издательство: Wiley
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Цена: 197420.00 T
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Описание: Promoting a continued and much-needed renaissance in biopharmaceutical manufacturing, this book covers the different strategies and assembles top-tier technology experts to address the challenges of antibody purification.

Current Trends in Monoclonal Antibody Development and Manufacturing

Автор: Steven J. Shire; Wayne Gombotz; Karoline Bechtold-
Название: Current Trends in Monoclonal Antibody Development and Manufacturing
ISBN: 1461424917 ISBN-13(EAN): 9781461424918
Издательство: Springer
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Цена: 191550.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides an understanding of the development, manufacturing techniques, and requirements of monoclonal antibodies. Covering one of the fastest growing areas of drug development, readers will find an informative text that describes the parameters for a successful regulatory submission.

Therapeutic Antibodies

Автор: Antony S. Dimitrov (Ed.)
Название: Therapeutic Antibodies
ISBN: 1934115924 ISBN-13(EAN): 9781934115923
Издательство: Springer
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Цена: 204970.00 T
Наличие на складе: Нет в наличии.
Описание: Presents a set of protocols for the discovery and development of therapeutic antibodies, featuring sections focusing on recombinant antigens, antibody libraries, antibody discovery, antibody engineering and antibody preclinical development. This work is suitable for those investigating and participating in this therapeutic market segment.


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