The Role of Beta Receptor Agonist Therapy in Asthma Mortality, Beasley, Richard , Pearce, Neil E.
Автор: George Poste; Stanley T. Crooke Название: Dopamine Receptor Agonists ISBN: 1475703120 ISBN-13(EAN): 9781475703122 Издательство: Springer Рейтинг: Цена: 113190.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Dopamine, in addition to its importance as a precursor of norepinephrine, is now known to be an important neurotransmitter in regulating functional activities in a number of major organ systems, including the central ner- vous system.
Автор: John P. Perkins Название: The Beta-Adrenergic Receptors ISBN: 1461267722 ISBN-13(EAN): 9781461267720 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Prior to 1974, the adrenergic receptors were known only in- directly as entities that responded to drugs in a selective manner to mediate a variety of physiologically important responses. During the intervening years, our view of adrenergic receptors has changed dramatically. The availability of high affinity 125I-labeled radioligands selective for these receptors presaged an explosion of experimenta- tion utilizing direct binding assays to establish the biochemical properties of the receptor protein. In the opening chapter, Stadel and Lefkowitz describe this development and its impact on our under- standing of the molecular basis of adrenergic receptor function. The availability of well-characterized receptor ligands, coupled with the development of efficient methods for detergent solubilization, formed the basis of receptor purification using affinity chromatography. The related technique of photoaffinity labeling provided a means to estimate the molecular mass of these receptors. The availability of substantial amounts of purified 2-adrenergic receptor allowed determination of segments of its amino acid se- quence. This information led to the production of polynucleotide probes and eventually to cloning of the receptor gene and determi- nation of the complete primary sequence of the receptor protein. Caron and Lefkowitz review the investigations leading to this major development and discuss the methods involved. They analyze our current perception of the relation of receptor function to its structure and discuss the general features of the G protein-interacting receptor family, of which the -adrenergic receptors are prototypes.
Автор: Friedrich Kummer Название: Treatment of Asthma: The long-acting beta-2-agonists ISBN: 321183124X ISBN-13(EAN): 9783211831243 Издательство: Springer Рейтинг: Цена: 81050.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This work constitutes the proceedings of the 6th Vienna Asthma Forum, which discussed the role of three compounds (bambuterol, formoterol and salmeterol) in the treatment of asthma. The contributors seek to provide an insight into the physiology of the beta-2 and glucocorticoid receptor.
Автор: Bernd Nilius; Veit Flockerzi Название: Mammalian Transient Receptor Potential (TRP) Cation Channels ISBN: 3662512238 ISBN-13(EAN): 9783662512234 Издательство: Springer Рейтинг: Цена: 330870.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book offers up-to-date information on the molecular and functional properties and pharmacology of mammalian Transient Receptor Potential channels, from close-up views of single protein/channels to broader principles of function and important pathologies.
Автор: A. Cato; H. Schaecke; K. Asadullah Название: Recent Advances in Glucocorticoid Receptor Action ISBN: 3662046628 ISBN-13(EAN): 9783662046623 Издательство: Springer Рейтинг: Цена: 174150.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Bowery Norman G Название: Allosteric Receptor Modulation In Drug Targeting ISBN: 0824727916 ISBN-13(EAN): 9780824727918 Издательство: Taylor&Francis Рейтинг: Цена: 193950.00 T Наличие на складе: Невозможна поставка. Описание: Allosteric Receptor Modulation in Drug Targeting
Автор: Emily M. Jutkiewicz Название: Delta Opioid Receptor Pharmacology and Therapeutic Applications ISBN: 303006980X ISBN-13(EAN): 9783030069803 Издательство: Springer Рейтинг: Цена: 107130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume describes our current understanding of the biological role of the delta-opioid receptor (DOR) system, focusing on its unique mechanisms of receptor trafficking and signaling in disease states. Part 1 covers the endogenous ligands that regulate the DOR system as well as novel compounds and therapies used to modulate the DOR system. Part 2 describes new insights into the localization and trafficking of the DOR and how ligand-directed signaling alters the fate of the receptor. Part 3 concentrates on the potential role of the DOR system in disease states, such as pain, mood, addiction, and Parkinson’s disease. Throughout the book, the DOR system as a target for drug development will be discussed.
Автор: Martins Sofia Aires M., Prazeres Duarte Miguel F. Название: G Protein-Coupled Receptor Screening Assays: Methods and Protocols ISBN: 1071612204 ISBN-13(EAN): 9781071612200 Издательство: Springer Цена: 111790.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume in the Encyclopedia of Sustainability Science and Technology, Second Edition, describes the breadth of science and engineering knowledge critical to advancing sustainable built environments, from architecture and design, mechanical engineering, lighting, and materials to water and energy, public policy, and economics.
Автор: Mario Tiberi Название: G Protein-Coupled Receptor Signaling ISBN: 1493991205 ISBN-13(EAN): 9781493991204 Издательство: Springer Рейтинг: Цена: 167700.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This detailed volume assembles comprehensive protocols to assist with the study of structural, molecular, cell biological, and in vivo facets of GPCRs, and to enable the development of experimental tools for screening novel GPCR drugs. Sections explore the tweaking of ligands, bioluminescence and FRET approaches, specific GPCR signaling properties, as well as visualization of subcellular compartmentalization. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, G Protein-Coupled Receptor Signaling: Methods and Protocols serves as an ideal reference for life scientists working in a variety of research fields including molecular pharmacology, cell and developmental biology, brain behavior and physiology, drug development and screening.
Chapter 4 is available open access under a CC BY 4.0 license via link.springer.com.
Автор: Foreman J. Название: Textbook of Receptor Pharmacology ISBN: 0849310296 ISBN-13(EAN): 9780849310294 Издательство: Taylor&Francis Рейтинг: Цена: 87790.00 T Наличие на складе: Нет в наличии. Описание: The bestselling first edition of Textbook of Receptor Pharmacology originated from a renowned course in receptor pharmacology taught at the University College of London for the past three decades. Its innovative format united four major approaches to the study of receptors: molecular biology, quantitative functional studies of agonists and antagonists, ligand binding, and signal transduction systems. The second edition builds on this foundation.This edition streamlines the material and focuses on cell membrane receptors along with their immediate signal transducers. The section on the molecular structure of receptors reflects the advances in this area. This edition also includes two restructured new chapters, one on G-proteins and one on tyrosine kinases, as signal transductors. Several chapters also contain problems for students to solve as well as worked-out solutions.The book contains over one hundred useful diagrams and tables to aid illustration of concepts and a helpful appendix explaining the simple mathematics used in the text. A time-saving resource and comprehensive textbook, Textbook of Receptor Pharmacology, Second Edition provides in-depth, up-to-date coverage of this
Автор: T. Kenakin; J. A. Angus Название: The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems ISBN: 3642630286 ISBN-13(EAN): 9783642630286 Издательство: Springer Рейтинг: Цена: 121890.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: With contributions by numerous experts
Автор: Craig W. Stevens Название: G Protein-Coupled Receptor Genetics ISBN: 1493963325 ISBN-13(EAN): 9781493963324 Издательство: Springer Рейтинг: Цена: 111790.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: G Protein-Coupled Receptor Genetics: Research and Methods in the Post-Genomic Era features practical techniques inspired by the fast moving GPCR field.
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