Genome Editing: A Comprehensive Treatise, Gurbachan S. Miglani
Автор: Holmqvist, Kenneth; Nystrom, Marcus; Andersson, Ri Название: Eye Tracking: A comprehensive guide to methods and measures ISBN: 0198738595 ISBN-13(EAN): 9780198738596 Издательство: Oxford Academ Рейтинг: Цена: 60190.00 T Наличие на складе: Поставка под заказ. Описание: For centuries private bankers owned and managed their banks, usually with unlimited liability.In the mid-19th century they faced increasing competition. This book traces the rise and decline of this original form of banking, and its revival in the late 20th century as a response to the development of a new market - the management of personal wealth
Автор: Byrne, John H. Название: Learning and Memory: A Comprehensive Reference ISBN: 0128051590 ISBN-13(EAN): 9780128051597 Издательство: Elsevier Science Рейтинг: Цена: 1667480.00 T Наличие на складе: Поставка под заказ. Описание:
Learning and Memory: A Comprehensive Reference, Second Edition, Four Volume Set is the authoritative resource for scientists and students interested in all facets of learning and memory. This updated edition includes chapters that reflect the state-of-the-art of research in this area. Coverage of sleep and memory has been significantly expanded, while neuromodulators in memory processing, neurogenesis and epigenetics are also covered in greater detail. New chapters have been included to reflect the massive increase in research into working memory and the educational relevance of memory research. No other reference work covers so wide a territory and in so much depth.
Автор: Takashi Yamamoto Название: Targeted Genome Editing Using Site-Specific Nucleases ISBN: 4431562354 ISBN-13(EAN): 9784431562351 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Поставка под заказ. Описание: This book serves as an introduction to targeted genome editing, beginning with the background of this rapidly developing field and methods for generation of engineered nucleases. Applications of genome editing tools are then described in detail, in iPS cells and diverse organisms such as mice, rats, marine invertebrates, fish, frogs, and plants. Tools that are mentioned include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9, all of which have received much attention in recent years as breakthrough technologies. Genome editing with engineered nucleases allows us to precisely change the target genome of living cells and is a powerful way to control functional genes. It is feasible in almost all organisms ranging from bacteria to plants and animals, as well as in cultured cells such as ES and iPS cells. Various genome modifications have proven successful, including gene knockout and knock-in experiments with targeting vectors and chromosomal editing. Genome editing technologies hold great promise for the future, for example in biomedical research, clinical medicine, and generation of crops and livestock with desirable traits. A wide range of readers will find this book interesting, and with its focus on applications in a variety of organisms and cells, the book will be valuable for life scientists in all fields.
Автор: Turksen Название: Genome Editing ISBN: 3319341464 ISBN-13(EAN): 9783319341460 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
This timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text contextualizes these methods in treatment of cardiovascular disease, diabetes mellitus, retinitis pigmentosa, and others. The final chapters round out the book with a discussion of controversies and future directions.
Genome Editing is an essential, of-the-moment contribution to this rapidly growing field. Drawing from a wealth of international perspectives, it presents novel techniques and applications for the engineering of the human genome. This book is essential reading for all clinicians and researchers in stem cells, regenerative medicine, genomics, biochemical and biomedical engineering- especially those interested in learning more about genome editing and applying it in a targeted, specific way.
Автор: Jean C Zenklusen Название: Collaborative Genomics Projects: A Comprehensive Guide ISBN: 0128021438 ISBN-13(EAN): 9780128021439 Издательство: Elsevier Science Рейтинг: Цена: 69610.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: "
Collaborative Genomics Projects: A Comprehensive Guide" contains operational procedures, policy considerations, and the many lessons learned by The Cancer Genome Atlas Project. This book guides the reader through methods in patient sample acquisition, the establishment of data generation and analysis pipelines, data storage and dissemination, quality control, auditing, and reporting.
This book is essential for those looking to set up or collaborate within a large-scale genomics research project. All authors are contributors to The Cancer Genome Atlas (TCGA) Program, a NIH- funded effort to generate a comprehensive catalog of genomic alterations in more than 35 cancer types.
As the cost of genomic sequencing is decreasing, more and more researchers are leveraging genomic data to inform the biology of disease. The amount of genomic data generated is growing exponentially, and protocols need to be established for the long-term storage, dissemination, and regulation of this data for research. The book's authors create a complete handbook on the management of research projects involving genomic data as learned through the evolution of the TCGA program, a project that was primarily carried out in the US, but whose impact and lessons learned can be applied to international audiences. Establishes a framework for managing large-scale genomic research projects involving multiple collaboratorsDescribes lessons learned through TCGA to prepare for potential roadblocksEvaluates policy considerations that are needed to avoid pitfallsRecommends strategies to make project management more efficient
Автор: Daniel Ladant Название: The Comprehensive Sourcebook of Bacterial Protein Toxins ISBN: 0128001887 ISBN-13(EAN): 9780128001882 Издательство: Elsevier Science Рейтинг: Цена: 213350.00 T Наличие на складе: Невозможна поставка. Описание:
The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content.
Descriptions of relevant toxins as well as representative toxins of the main bacterial toxin families to allow for a better comparison between them
Focused chapters on toxin applications and common properties or general features of toxins
Автор: G?nther Witzany Название: Biocommunication and Natural Genome Editing ISBN: 9048133181 ISBN-13(EAN): 9789048133185 Издательство: Springer Рейтинг: Цена: 156720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book provides a uniform description of all key levels of communication in the organismic kingdoms of plants, fungi, animals, bacteria and additionally the natural genome editing competences of viruses based on the most recent empirical data.
Автор: Toni Cathomen; Matthew Hirsch; Matthew Porteus Название: Genome Editing ISBN: 1493935070 ISBN-13(EAN): 9781493935079 Издательство: Springer Рейтинг: Цена: 130610.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: "American Society of Gene & Cell Therapy"--Cover.
Автор: McQueen, Charlene Название: Comprehensive Toxicology ISBN: 0081006012 ISBN-13(EAN): 9780081006016 Издательство: Elsevier Science Рейтинг: Цена: 0.00 T Наличие на складе: Поставка под заказ. Описание: Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology.
Автор: Rudolf Jaenisch; Feng Zhang; Fred Gage Название: Genome Editing in Neurosciences ISBN: 3319601911 ISBN-13(EAN): 9783319601915 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book is open access under a CC BY 4.0 license.
CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease.
This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.
Автор: G?nther Witzany Название: Biocommunication and Natural Genome Editing ISBN: 9400791143 ISBN-13(EAN): 9789400791145 Издательство: Springer Рейтинг: Цена: 156720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book provides a uniform description of all key levels of communication in the organismic kingdoms of plants, fungi, animals, bacteria and additionally the natural genome editing competences of viruses based on the most recent empirical data.
Автор: Heinz Fraenkel-Conrat Название: Comprehensive Virology ISBN: 1468435655 ISBN-13(EAN): 9781468435658 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This comprehensive series, which will comprise some 6000 pages in a total of about 18 volumes, represents a commitment by a large group of active investigators to analyze, digest, and expostulate on the great mass of data relating to viruses, much of which is now amorphous and disjointed, and scattered throughout a wide literature.
Казахстан, 010000 г. Астана, проспект Туран 43/5, НП2 (офис 2) ТОО "Логобук" Тел:+7 707 857-29-98 ,+7(7172) 65-23-70 www.logobook.kz
