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Collaborative Genomics Projects: A Comprehensive Guide, Jean C Zenklusen


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Автор: Jean C Zenklusen
Название:  Collaborative Genomics Projects: A Comprehensive Guide
ISBN: 9780128021439
Издательство: Elsevier Science
Классификация:


ISBN-10: 0128021438
Обложка/Формат: Paperback
Страницы: 400
Вес: 0.33 кг.
Дата издания: 18.02.2016
Язык: English
Размер: 237 x 191 x 11
Ссылка на Издательство: Link
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Поставляется из: Европейский союз
Описание:

Collaborative Genomics Projects: A Comprehensive Guide contains operational procedures, policy considerations, and the many lessons learned by The Cancer Genome Atlas Project. This book guides the reader through methods in patient sample acquisition, the establishment of data generation and analysis pipelines, data storage and dissemination, quality control, auditing, and reporting.

This book is essential for those looking to set up or collaborate within a large-scale genomics research project. All authors are contributors to The Cancer Genome Atlas (TCGA) Program, a NIH- funded effort to generate a comprehensive catalog of genomic alterations in more than 35 cancer types.

As the cost of genomic sequencing is decreasing, more and more researchers are leveraging genomic data to inform the biology of disease. The amount of genomic data generated is growing exponentially, and protocols need to be established for the long-term storage, dissemination, and regulation of this data for research. The books authors create a complete handbook on the management of research projects involving genomic data as learned through the evolution of the TCGA program, a project that was primarily carried out in the US, but whose impact and lessons learned can be applied to international audiences.
Establishes a framework for managing large-scale genomic research projects involving multiple collaboratorsDescribes lessons learned through TCGA to prepare for potential roadblocksEvaluates policy considerations that are needed to avoid pitfallsRecommends strategies to make project management more efficient


The Comprehensive Sourcebook of Bacterial Protein Toxins

Автор: Daniel Ladant
Название: The Comprehensive Sourcebook of Bacterial Protein Toxins
ISBN: 0128001887 ISBN-13(EAN): 9780128001882
Издательство: Elsevier Science
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Цена: 213350.00 T
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The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content.

  • Descriptions of relevant toxins as well as representative toxins of the main bacterial toxin families to allow for a better comparison between them
  • Focused chapters on toxin applications and common properties or general features of toxins


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