Molecular Recognition of DNA Double Helix, Abhijit Saha

Автор: Didenko Vladimir V.
Название: In Situ Detection of DNA Damage / Methods and Protocols
ISBN: 0896039528 ISBN-13(EAN): 9780896039520
Издательство: Springer
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Цена: 38730.00 T
Наличие на складе: Есть
Описание: In In Situ Detection of DNA Damage: Methods and Protocols, Vladimir Didenko and a panel of experts describe all the major in situ techniques for studying DNA damage and apoptosis, and how approaches originally designed to label apoptotic cells can be used for DNA damage analysis (and vice versa). The readily reproducible techniques presented here include all those designed to detect specific single- and double-stranded DNA breaks in tissue sections while using polymerases, ligases, nucleases, and kinases. There are also novel instrumental techniques that use ultrasound for in vivo and in situ detection of apoptotic DNA damage, and in situ applications of flow and laser-scanning cytometry for analysis of DNA strand breaks and apoptosis. State-of-the-art and highly practical, In Situ Detection of DNA Damage: Methods and Protocols presents for the first time a complete set of enzymatic methods for determining DNA breaks, and will greatly facilitate the work of all those studying the in situ detection of DNA damage and the labeling of apoptotic cells.

Автор: Andreas Hofmann
Название: Wilson and walker`s principles and techniques of biochemistry and molecular biology
ISBN: 1107162270 ISBN-13(EAN): 9781107162273
Издательство: Cambridge Academ
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Цена: 126720.00 T
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Описание: This best-selling undergraduate textbook introduces the key experimental techniques from across the biosciences. It uniquely integrates the theories and methods driving the fields of biology and medicine, comprehensively covering both the techniques that students will encounter in lab classes and those that underpin recent advances and discoveries.

Автор: W.E.G. M?ller; H.C. Schr?der
Название: Biological Response Modifiers — Interferons, Double-Stranded RNA and 2?,5?-Oligoadenylates
ISBN: 3642785514 ISBN-13(EAN): 9783642785511
Издательство: Springer
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Цена: 121110.00 T
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Описание: Biological response modifiers are increasingly used in viral and cancer therapy. Since alterations of the immune system are the primary symptoms of HIV infection, especially therapies directed towards the modulation of the immune response have been under intense evaluation.

Автор: Yogambigai Velmurugu
Название: Dynamics and Mechanism of DNA-Bending Proteins in Binding Site Recognition
ISBN: 3319451286 ISBN-13(EAN): 9783319451282
Издательство: Springer
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Цена: 111790.00 T
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Описание: Using a novel approach that combines high temporal resolution of the laser T-jump technique with unique sets of fluorescent probes, this study unveils previously unresolved DNA dynamics during search and recognition by an architectural DNA bending protein and two DNA damage recognition proteins. Many cellular processes involve special proteins that bind to specific DNA sites with high affinity. How these proteins recognize their sites while rapidly searching amidst ~3 billion nonspecific sites in genomic DNA remains an outstanding puzzle. Structural studies show that proteins severely deform DNA at specific sites and indicate that DNA deformability is a key factor in site-specific recognition. However, the dynamics of DNA deformations have been difficult to capture, thus obscuring our understanding of recognition mechanisms. The experiments presented in this thesis uncover, for the first time, rapid (~100-500 microseconds) DNA unwinding/bending attributed to nonspecific interrogation, prior to slower (~5-50 milliseconds) DNA kinking/bending/nucleotide-flipping during recognition. These results help illuminate how a searching protein interrogates DNA deformability and eventually “stumbles” upon its target site. Submillisecond interrogation may promote preferential stalling of the rapidly scanning protein at cognate sites, thus enabling site-recognition. Such multi-step search-interrogation-recognition processes through dynamic conformational changes may well be common to the recognition mechanisms for diverse DNA-binding proteins.

Автор: Siede, Wolfram
Название: DNA Damage Recognition
ISBN: 0824759613 ISBN-13(EAN): 9780824759612
Издательство: Taylor&Francis
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Цена: 275610.00 T
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Автор: Yu Zutao
Название: Artificial Assemblies with Cooperative DNA Recognition
ISBN: 9811544220 ISBN-13(EAN): 9789811544224
Издательство: Springer
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Цена: 93160.00 T
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Описание: This book presents three types of synthetically cooperative DNA recognizing assemblies, in order to advance the development of programmable DNA-binding pyrrole-imidazole polyamides (PIPs). PIPs are characterized by their small molecular size, high binding affinity, programmability, sequence selectivity, and moderate cell permeability.

Автор: Yu Zutao
Название: Artificial Assemblies with Cooperative DNA Recognition
ISBN: 9811544255 ISBN-13(EAN): 9789811544255
Издательство: Springer
Цена: 93160.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents three types of synthetically cooperative DNA recognizing assemblies, in order to advance the development of programmable DNA-binding pyrrole-imidazole polyamides (PIPs). PIPs are characterized by their small molecular size, high binding affinity, programmability, sequence selectivity, and moderate cell permeability.

Автор: Chatterji, Dipankar
Название: Basics of Molecular Recognition
ISBN: 1482219689 ISBN-13(EAN): 9781482219685
Издательство: Taylor&Francis
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Цена: 183750.00 T
Наличие на складе: Нет в наличии.

Автор: Ben-Naim Arieh
Название: Molecular Theory Of Water And Aqueous Solutions - Part Ii: The Role Of Water In Protein Folding, Self-Assembly And Molecular Recognition
ISBN: 9814350532 ISBN-13(EAN): 9789814350532
Издательство: World Scientific Publishing
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Цена: 158400.00 T
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Описание: Starts out by presenting the evidence for hydrophilic interactions in biochemical processes and then goes on to describe the applications of the hydrophilic interactions in these processes, specifically protein folding, protein association, self assembly and molecular recognition.

Автор: Ben-Naim Arieh
Название: Molecular Theory Of Water And Aqueous Solutions - Part Ii: The Role Of Water In Protein Folding, Self-Assembly And Molecular Recognition
ISBN: 9814350540 ISBN-13(EAN): 9789814350549
Издательство: World Scientific Publishing
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Цена: 28510.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Starts out by presenting the evidence for hydrophilic interactions in biochemical processes and then goes on to describe the applications of the hydrophilic interactions in these processes, specifically protein folding, protein association, self assembly and molecular recognition.

Автор: Volker A. Erdmann; Jan Barciszewski
Название: DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases
ISBN: 3642368522 ISBN-13(EAN): 9783642368523
Издательство: Springer
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Цена: 174150.00 T
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Описание: This book covers the design and synthesis of DNA and RNA nanostructures with the aim of using them for drug deliveries, for genetic immunization, for metabolite and nucleic acid detection, gene regulation, and siRNA delivery for cancer treatment.

Автор: Saha
Название: Molecular Recognition of DNA Double Helix
ISBN: 9811087458 ISBN-13(EAN): 9789811087455
Издательство: Springer
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Цена: 102480.00 T
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Описание: In this book, the molecular recognition of DNA using small molecules is discussed, with a study of the photochemistry of BrU-labeled DNA.