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Chirality, Rudolf Janoschek


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Автор: Rudolf Janoschek
Название:  Chirality
ISBN: 9783642765711
Издательство: Springer
Классификация:






ISBN-10: 3642765718
Обложка/Формат: Soft cover
Страницы: 246
Вес: 0.41 кг.
Дата издания: 23.12.2011
Язык: English
Издание: Softcover reprint of
Иллюстрации: 18 tables, black and white; 24 illustrations, black and white; xi, 246 p. 24 illus.
Размер: 234 x 156 x 14
Читательская аудитория: Professional & vocational
Основная тема: Organic Chemistry
Подзаголовок: From Weak Bosons to the ?-Helix
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Les hypotheses, nen deplaise a mon contradicteur, sont lame des progres de la science. Louis Pasteur The concept of chirality, established 100 years ago, plays an im- portant role in almost all domains and dimensions of our recent scientific view of life. Chiral properties can be found in fundamen- tal nuclear particles, in molecules, and in the macroscopic world of living nature (plants and animals) and inanimate nature (crystals). In particular, chirality, or more precisely chiral excess, is evident in human beings. For example, the expected symmetry of the hands turns out to be functionally non-existent. Consequently chirality occurs in the technical sphere, where screws are the best-known examples, since most of them are made for right-handed people. Chirality is not confined to static objects but influences processes such as chemical reactions. The occurrence of chiral objects on different dimensional scales has been treated in the past in mutually independent frameworks. There were, however, two remarkable events from which the conclu- sion can be drawn that the appearance of chirality in various fields has a common cause. On the one hand, physicists found evidence that the well-known biomolecular homochirality can be traced back to the chirality of weak bosons. At the same time, on the other hand, the so-called thalidomide tragedy occurred when thalido- mide molecules of a certain chirality, taken by pregnant women, caused deformed children.

Chirality in Drug Design and Development

Автор: Indra K. Reddy, Reza Mehvar
Название: Chirality in Drug Design and Development
ISBN: 0824750624 ISBN-13(EAN): 9780824750626
Издательство: Taylor&Francis
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Цена: 265410.00 T
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Описание:

Covering every essential element in the development of chiral products, this reference provides a solid overview of the formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals. It supports researchers as they evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds and addresses in one convenient reference all the major challenges pertaining to drug chirality that have been neglected in the literature. Chirality in Drug Design and Development collects the latest studies from an interdisciplinary team of experts on chiral drug design.



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