Автор: Didenko Vladimir V. Название: In Situ Detection of DNA Damage / Methods and Protocols ISBN: 0896039528 ISBN-13(EAN): 9780896039520 Издательство: Springer Рейтинг: Цена: 38730.00 T Наличие на складе: Есть Описание: In In Situ Detection of DNA Damage: Methods and Protocols, Vladimir Didenko and a panel of experts describe all the major in situ techniques for studying DNA damage and apoptosis, and how approaches originally designed to label apoptotic cells can be used for DNA damage analysis (and vice versa). The readily reproducible techniques presented here include all those designed to detect specific single- and double-stranded DNA breaks in tissue sections while using polymerases, ligases, nucleases, and kinases. There are also novel instrumental techniques that use ultrasound for in vivo and in situ detection of apoptotic DNA damage, and in situ applications of flow and laser-scanning cytometry for analysis of DNA strand breaks and apoptosis. State-of-the-art and highly practical, In Situ Detection of DNA Damage: Methods and Protocols presents for the first time a complete set of enzymatic methods for determining DNA breaks, and will greatly facilitate the work of all those studying the in situ detection of DNA damage and the labeling of apoptotic cells.
Автор: D. R. Garrod Название: Specificity of Embryological Interactions ISBN: 0412144204 ISBN-13(EAN): 9780412144202 Издательство: Springer Рейтинг: Цена: 81050.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Zhen Cui; Jinshan Pan; Shanshan Zhang; Liang Xiao; Название: Intelligence Science and Big Data Engineering. Visual Data Engineering ISBN: 3030361888 ISBN-13(EAN): 9783030361884 Издательство: Springer Рейтинг: Цена: 76390.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The two volumes LNCS 11935 and 11936 constitute the proceedings of the 9th International Conference on Intelligence Science and Big Data Engineering, IScIDE 2019, held in Nanjing, China, in October 2019.The 84 full papers presented were carefully reviewed and selected from 252 submissions.The papers are organized in two parts: visual data engineering; and big data and machine learning. They cover a large range of topics including information theoretic and Bayesian approaches, probabilistic graphical models, big data analysis, neural networks and neuro-informatics, bioinformatics, computational biology and brain-computer interfaces, as well as advances in fundamental pattern recognition techniques relevant to image processing, computer vision and machine learning.
Автор: Paul R. Crocker Название: Mammalian Carbohydrate Recognition Systems ISBN: 3642536700 ISBN-13(EAN): 9783642536700 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In the last decade there has been a great expansion in our knowledge of the existence, nature and functions of mammalian carbohydrate binding proteins.
Автор: K. Longberg-Holm Название: Virus Receptors ISBN: 9401180245 ISBN-13(EAN): 9789401180245 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: It is hardly necessary to define the concept of receptors to readers of this series, but it should be borne in mind that in several instances receptors are undefined entities, whose molecular details remain to be established.
Автор: Ronald S.S. Fraser Название: Recognition and Response in Plant-Virus Interactions ISBN: 3642741665 ISBN-13(EAN): 9783642741661 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of the NATO Advanced Research Workshop on Recognition and Response in Plant-Virus Interactions, held at Chichester, West Sussex, U.K., April 12-16, 1989
Автор: Vladimir V. Didenko Название: In Situ Detection of DNA Damage ISBN: 1617372722 ISBN-13(EAN): 9781617372728 Издательство: Springer Рейтинг: Цена: 135090.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Detection and analysis of DNA damage is of critical importance in a variety of biological disciplines studying apoptosis, cell cycle and cell di- sion, carcinogenesis, tumor growth, embryogenesis and aging, neu- degenerative and heart diseases, anticancer drug development, environmental and radiobiological research, and others. Individual cells within the same tissue or in cell culture may vary in the extent of their DNA damage and, consequently, can display different re- tions to it. These differences between individual cells in the same cell popu- tion are detected using in situ approaches. In situ is a Latin term meaning "on site" or "in place." It is used to denote the processes occurring or detected in their place of origin. In mole- lar and cell biology this usually refers to undisrupted mounted cells or tissue sections. In that meaning "in situ" is used as part of the terms "in situ PCR," "in situ transcription," "in situ hybridization," "in situ end labeling," and "in situ ligation." Sometimes the "in situ" term is applied at the subcellular level to cells disrupted in the process of analysis, for example, in the detection of specific sequences in chromosomes using fluorescent in situ hybridization (FISH). Historically, the term was used primarily in methods dealing with nucleic acids.
Автор: Clemens Sonntag Название: Free-Radical-Induced DNA Damage and Its Repair ISBN: 3642065546 ISBN-13(EAN): 9783642065545 Издательство: Springer Рейтинг: Цена: 304750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon.
Автор: Huidong Zhang Название: DNA Replication - Damage from Environmental Carcinogens ISBN: 9401772118 ISBN-13(EAN): 9789401772112 Издательство: Springer Рейтинг: Цена: 51230.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book reviews the main concepts concerning DNA damage due to environmental carcinogens, the effects of DNA damage on DNA replication using a single DNA polymerase or DNA replisome, and the effects of carcinogens on various cell activities. It also introduces the detailed protocols for bypassing DNA damage. As we know, various environmental carcinogens are produced as a result of industry, agriculture, chemical engineering and vehicle exhaust in our daily life. It has been reported that the environmental carcinogens can be connected to tumors and cancer, directly threatening human health. In this regard, DNA replication is highly susceptible to damage. This book provides graduate students and researchers with an overview of the effects of environmental carcinogens on DNA replication and biological activities in cells. It offers important information for research in the areas of biochemistry, cell biology, medicine, toxicology and public health.
Автор: Jac A. Nickoloff; Merl F. Hoekstra Название: DNA Damage and Repair ISBN: 1475750153 ISBN-13(EAN): 9781475750157 Издательство: Springer Рейтинг: Цена: 174150.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention.
Автор: Jac A. Nickoloff; Merl F. Hoekstra Название: DNA Damage and Repair ISBN: 1468496352 ISBN-13(EAN): 9781468496352 Издательство: Springer Рейтинг: Цена: 139310.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The reviews cover a wide range of topics from viruses and prokaryotes to higher eukaryotes, and include several new topics, among them the role of recombination in replication of damaged DNA, X-ray crystallographic analysis of DNA repair protein structures, DNA repair proteins and teleomere function, and the roles of BRCA1 and BRCA2 in DNA repair.
Автор: Shrestha Ghosh Название: SIRT6 Activities in DNA Damage Repair and Premature Aging ISBN: 9813292660 ISBN-13(EAN): 9789813292666 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
This book illustrates the activities of mammalian sirtuin SIRT6 in connection with DNA damage repair and premature aging. It mainly presents research on the nuclear lamin A, notably the upregulation of p53 and acetylation etc. Taken together, these studies reveal the various regulatory roles of SIRT6, which are of substantial biological relevance in DNA damage repair, aging and longevity, and can have significant implications in devising therapeutic strategies to combat age-associated pathologies. Given its scope, the book offers a valuable resource for students and researchers in the fields of genetics, cell biology, molecular biology etc.
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