Proteomics of Peroxisomes, Luis A. del R?o; Michael Schrader

Автор: Luis A. del R?o; Michael Schrader
Название: Proteomics of Peroxisomes
ISBN: 9811347530 ISBN-13(EAN): 9789811347535
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Описание: This new edited volume in the Springer Subcellular Biochemistry Series presents a comprehensive, state-of-the-art overview of the proteomics of peroxisomes derived from mammalian, Drosophila, fungal, and plant origin, and contains contributions from leading experts in the field. The development of sensitive proteomics and mass spectrometry technologies, combined with bioinformatics approaches now allow the identification of low-abundance and transient peroxisomal proteins and permits to identify the complete proteome of peroxisomes, with the consequent increase of our knowledge of the metabolic and regulatory networks of these important cellular organelles. The book lines-up with these developments and is organized in four sections including: (i) mass spectrometry-based organelle proteomics; (ii) prediction of peroxisomal proteomes; (iii) analysis of peroxisome proteome interaction networks; and (iv) peroxisomes in relation to other subcellular compartments. The editor Luis A. del R?o is Professor ad honorem of the Spanish National Research Council (CSIC) in the Group of Antioxidants, Free Radicals and Nitric Oxide in Biotechnology, Food and Agriculture, Department of Biochemistry and Cell & Molecular Biology of Plants, at the Estaci?n Experimental del Zaid?n, Granada, Spain. Del R?o’s research group focuses on the metabolism of reactive oxygen species (ROS), reactive nitrogen species (RNS) and antioxidants in plant peroxisomes, and the ROS- and RNS-dependent role of peroxisomes in plant cell signalling. The editor Michael Schrader is Professor of Cell Biology & Cytopathology in the Department of Biosciences at the University of Exeter, UK. Using mammalian peroxisomes as model organelles, Prof. Schrader and his team aim to unravel the molecular machinery and signalling pathways that mediate and regulate the formation, dynamics and abundance of these medically relevant cellular compartments.

Автор: Michael Schrader
Название: Peroxisomes
ISBN: 1493969358 ISBN-13(EAN): 9781493969357
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Описание:

1. Isolation of Peroxisomes from Rat Liver and Cultured Hepatoma Cells by Density Gradient Centrifugation

Автор: Norbert Latruffe; Maurice Bugaut
Название: Peroxisomes
ISBN: 3642878091 ISBN-13(EAN): 9783642878091
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Автор: H. Dariush Fahimi; Helmut Sies
Название: Peroxisomes in Biology and Medicine
ISBN: 3642713270 ISBN-13(EAN): 9783642713279
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Описание: Peroxisomes (microbodies) have a long evolutionary lifespan, but in cell biology they are still young. It is gratifying to see that most recent advances in our knowledge of peroxisomes come from quite different disciplines, ranging from molecular biology and cell biology to clinical research. The identification in terms of cDNA sequences of enzymes, the localization in terms of immuno-electron microscopy, and the cell biological aspects of the organelle biogenesis have seen substantial progress very recently. Likewise, the phenomenon of peroxisome proliferation induced by a number of drugs, e. g. hypolipidemics and plasticizers, constitute an active area of research, where much is still to be learnt. The medical problem of inborn errors of metabolism seems to have gained a new realm for discovery. Here, the advances in knowledge within the last year have been particularly striking. Therefore, the "International Symposium on Peroxisomes in Biology and Medicine," held in Heidelberg from July 14-17,1986, was even more excit- ing than could have initially been anticipated. The present volume consists of papers from that conference. For sake of rapid publication, the camera- ready format, inspite of all its drawbacks (e. g. no proof reading by authors), was chosen. It is our pleasure to acknowledge support and help. The Symposium was supported by Deutsche Forschungsgemeinschaft, Bonn, by the Ministerium ftir Wissenschaft und Kunst Baden-Wtirttemberg, Stuttgart, as well as by a number of generous contributors from industry.

Автор: Schrader Michael
Название: Peroxisomes: Methods and Protocols
ISBN: 149398344X ISBN-13(EAN): 9781493983445
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Описание:

1. Isolation of Peroxisomes from Rat Liver and Cultured Hepatoma Cells by Density Gradient Centrifugation

Автор: A. Baker; I.A. Graham
Название: Plant Peroxisomes
ISBN: 9048160073 ISBN-13(EAN): 9789048160075
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Описание: In the two decades since the last comprehensive work on plant peroxisomes appeared, the scientific approaches employed in the study of plant biology have changed beyond all recognition.

Автор: Luis A. del R?o
Название: Peroxisomes and their Key Role in Cellular Signaling and Metabolism
ISBN: 9400768885 ISBN-13(EAN): 9789400768888
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Описание: Peroxisomes are a class of ubiquitous and dynamic single membrane-bounded cell organelles, devoid of DNA, with an essentially oxidative type of metabolism.

Автор: Luis A. del R?o
Название: Peroxisomes and their Key Role in Cellular Signaling and Metabolism
ISBN: 9401782903 ISBN-13(EAN): 9789401782906
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Описание: Peroxisomes are a class of ubiquitous and dynamic single membrane-bounded cell organelles, devoid of DNA, with an essentially oxidative type of metabolism.

Автор: Tsuneo Imanaka; Nobuyuki Shimozawa
Название: Peroxisomes: Biogenesis, Function, and Role in Human Disease
ISBN: 9811511683 ISBN-13(EAN): 9789811511684
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Описание: This book provides readers with a comprehensive overview of peroxisomes and their role in human diseases. It starts by describing the history of peroxisome research and then examines in detail the current understanding of the biogenesis and function of peroxisomes. It then focuses on peroxisomal disorders and the involvement of peroxisomes in cancer and age-related diseases, discussing in detail the use of model organisms to elucidate the pathogenesis of peroxisomal disorders and the physiological importance of peroxisomal proteins. Further, the book examines diagnostic and therapeutic strategies in peroxisomal disorders as well as significant recent advances. Lastly, it addresses various topics in peroxisome research, including the isolation of peroxisomes from mammalian tissues and cells, the structural biology of peroxisomal proteins, the lipidomics of peroxisomal disorders, the value of exome sequencing, and neuropsychological testing in X-linked adrenoleukodystrophy. Given its scope, the book is a valuable resource for postgraduate students and researchers in the life sciences and clinicians in the fields of internal medicine, pediatrics, and neurology.

Автор: R.J. Pollitt; A.H. van Gennip; C.J. de Groot; G.M.
Название: Inborn Errors of Cellular Organelles: Peroxisomes and Mitochondria
ISBN: 9401079277 ISBN-13(EAN): 9789401079273
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Описание: Proceedings of the 24th Annual Symposium of the SSIEM held in Amersfoort, the Netherlands, September 1986.

Автор: Rodrigo B. Valenzuela
Название: Peroxisome Profilerator-Activated Receptors (PPARs): Structure, Mechanisms of Action and Role in Health and Disease
ISBN: 1536147370 ISBN-13(EAN): 9781536147377
Издательство: Nova Science
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Цена: 215410.00 T
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Описание: Worldwide, the prevalence of chronic diseases, such as obesity, diabetes, cardiovascular diseases, cancer, non-alcoholic fatty liver disease, inflammatory (autoimmune) and neurodegenerative diseases, has shown a sharp increase. In the last 20 years, developing countries and the young population have presented the largest augment in the incidence of these diseases, which evidences that they are not only limited to developed countries nor the adult population. These pathologies have in common a complex interaction between genetic, metabolic and environmental factors. In this context, several basic and clinical researches have demonstrated the relevance of the expression and activity of the peroxisomal proliferator-activated receptors (PPARs) as fundamental elements in the prevention and treatment of chronic diseases. PPARs are a family of transcription factors that control many cellular metabolic processes. PPAR isoform expression and activity is regulated in different tissues according to physiological processes (growth, development, and aging) and to pathological conditions (cardiovascular diseases, inflammatory diseases, neurodegenerative diseases, hepatic diseases, among others). Also, different compounds such as drugs (fibrates), nutrients (long-chain polyunsaturated fatty acids), and several natural bioactive compounds (polyphenols) are molecular regulators of PPARs expression and activity. Recent research has established the importance of the regulation of PPARs activity and their role in cell and tissue protection against injury (i.e., oxidative stress, inflammation, endoplasmic reticulum stress). This book is dedicated to reviewing the state of the art regarding PPARs regulation with an emphasis on molecular aspects underlying their effect in health and disease. Specifically, the participation of PPARs is discussed in insulin resistance, inflammation, NAFLD, DM2, cardiovascular disease, hypertension, obesity, gastrointestinal disease, and neurological health and disease. Moreover, this book reviews how different molecules regulate the expression and activity of PPARs. Finally, the scientific information presented in this book pretends to contribute to a greater understanding of PPAR role in the prevention and treatment of different pathologies and metabolic alterations.

Автор: J.-C. Fruchart; Antonio M. Gotto Jr.; Rodolfo Paol
Название: Peroxisome Proliferator Activated Receptors: From Basic Science to Clinical Applications
ISBN: 140207199X ISBN-13(EAN): 9781402071997
Издательство: Springer
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Описание: Peroxisome Proliferator Activated Receptors (PPARs) attract great attention in light of the wide spectrum of genes of biological and medical relevance identified as under their control. This volume provides a view of the clinical and scientific developments within this area of study.