Models of Neurons and Perceptrons: Selected Problems and Challenges, Bielecki
Автор: D`Andrea Michael R. Название: Bursting Neurons and Fading Memories ISBN: 0128019794 ISBN-13(EAN): 9780128019795 Издательство: Elsevier Science Рейтинг: Цена: 53890.00 T Наличие на складе: Невозможна поставка. Описание:
Advances in Alzheimer's disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field's best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development.
The clear, compelling, and unifying "Inside-Out" hypothesis of AD is brought to life through a string of scientific publications, synthesizing many known features of disease pathology
A high-level text on AD pathology, and suggestions for progress in a stagnating field
Point-by-point discussion on the issues surrounding the current amyloid cascade, and possible reasons why current clinical trials have failed
Contains high-quality photomicrographs in support of the "Inside-Out" hypothesis using single, double, and triple immunohistochemistry on human AD CNS tissues
Chapters address the need for a unifying plaque nomenclature, the importance of intracellular amyloid, the blood-brain barrier, inflammation, and autoimmunity
This book describes models of the neuron and multilayer neural structures, with a particular focus on mathematical models. It also discusses electronic circuits used as models of the neuron and the synapse, and analyses the relations between the circuits and mathematical models in detail.
The first part describes the biological foundations and provides a comprehensive overview of the artificial neural networks. The second part then presents mathematical foundations, reviewing elementary topics, as well as lesser-known problems such as topological conjugacy of dynamical systems and the shadowing property. The final two parts describe the models of the neuron, and the mathematical analysis of the properties of artificial multilayer neural networks.
Combining biological, mathematical and electronic approaches, this multidisciplinary book it useful for the mathematicians interested in artificial neural networks and models of the neuron, for computer scientists interested in formal foundations of artificial neural networks, and for the biologists interested in mathematical and electronic models of neural structures and processes.
Название: Physiology of Neurons ISBN: 081534600X ISBN-13(EAN): 9780815346005 Издательство: Taylor&Francis Рейтинг: Цена: 117390.00 T Наличие на складе: Нет в наличии. Описание: This book systematically explores the details of neuronal physiology, covering membrane biophysics, receptor physiology, sensory transduction and synaptic transmission with its selective pharmacology. Undergraduates will be fully equipped to understand the functions and possibilities of the key units of the brain`s parallel computations.
Автор: Christine Heym Название: Histochemistry and Cell Biology of Autonomic Neurons and Paraganglia ISBN: 3642727514 ISBN-13(EAN): 9783642727511 Издательство: Springer Рейтинг: Цена: 81050.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: With the discovery of an ever increasing number of biogenetic polypeptides in the autonomic nervous system, it is evident that nervous transmission is controlled and modified not only by a series of classical transmitters but also by a variety of co-transmitters and modulators. Purifi- cation, characterization and synthesis of neuropeptides and peptide families allows the application of specific anti- bodies for radioimmunological, immunohistochemical and immunocytochemical localization. Transmitter interactions and phenotypic neuronal plasticity can be analyzed by pharmacological or surgical manipulations. Biochemical and autoradiographic determination of specific membrane receptors enables the recognition of peptide target struc- tures. In addition, neurophysiological techniques in combi- nation with histochemical methods result in functional interpretations. With regard to somatic manifestations of autonomic nervous disturbances these studies will offer fundamental insights for clinical medicine. This volume contains the refereed proceedings of recent investigations on histochemistry and cell biology of auton- omic neurons and paraganglia which were presented at an international colloquium on nervous transmission in Heidelberg in September 1986. The colloquium was origi- nally planned to be held under the presidency of Olavi Eranko but was continued by the editor after his death. It was sponsored by the German Research Foundation and took place on the occasion of the 600th anniversary of the Heidelberg University "Ruperto Carola" as part of the pro- gram in the international "Wissenschaftsforum". Hopefully, the information provided in this book will stimu- late new ideas and research strategies in the field of neu roscience.
Автор: W.A. Ribi Название: The Neurons of the First Optic Ganglion of the Bee (Apis mellifera) ISBN: 3540070966 ISBN-13(EAN): 9783540070962 Издательство: Springer Рейтинг: Цена: 81050.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The visual system of insects has attracted histologists for a long time. We have detailed histological studies of the visual systems of Diptera, Hymenoptera and Odonata dating from the last century: Leydig's (1864) study on optical ganglia of insects, Ciaccio's (1876) on the fine structure of the first ganglion in the mosquitos and Hickson's (1885) giving for the first time an exact description of the three optical ganglia of Musca. From 1896 several papers appeared using neuro- histological methods, mainly Golgi techniques and methylene blue staining. In 1896 Kenyon published his work on the bee-brain and in 1897 described the relationships of neurons in the optic ganglia with a modified Golgi method. Another work, by Jonescu (1909), should be mentioned: "Vergleichende Unter- suchungen am Gehirn der Honigbiene." In the same year Cajal's findings on the optic ganglia of the fly were published; then in 1915 Cajal and Sanchez wrote a definitive monograph on the neural elements and their connections in the same animal that remained the main reference in this field for decades. In both works Golgi techniques were used. Since then there have been only a few new publications on the subject: (Gribakin, 1967; Perrelet and Baumann, 1969 a, b; Perrelet, 1970; Varela and Porter, 1969; Skrzipek and Skrzipek, 1971, 1973; Grundler, 1972: Snyder, Menzel and Laughlin, 1973). They deal mainly with the receptors of the retina.
Автор: Alain Dabdoub; Bernd Fritzsch; Arthur N. Popper; R Название: The Primary Auditory Neurons of the Mammalian Cochlea ISBN: 1493947303 ISBN-13(EAN): 9781493947300 Издательство: Springer Рейтинг: Цена: 102480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: A comprehensive review about the spiral ganglion neurons is important for researchers not only in the inner ear field but also in development, neuroscience, biophysics as well as neural networks researchers.
Автор: Hickok Gregory Название: The Myth of Mirror Neurons: The Real Neuroscience of Communication and Cognition ISBN: 0393089614 ISBN-13(EAN): 9780393089615 Издательство: Wiley Рейтинг: Цена: 39600.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: An essential reconsideration of one of the most far-reaching theories in modern neuroscience and psychology.
Название: Physiology of Neurons ISBN: 0367263750 ISBN-13(EAN): 9780367263751 Издательство: Taylor&Francis Рейтинг: Цена: 265410.00 T Наличие на складе: Нет в наличии. Описание: This book systematically explores the details of neuronal physiology, covering membrane biophysics, receptor physiology, sensory transduction and synaptic transmission with its selective pharmacology. Undergraduates will be fully equipped to understand the functions and possibilities of the key units of the brain`s parallel computations.
Автор: Geoffrey Burnstock and Marcello Costa Название: Adrenergic Neurons ISBN: 0412140608 ISBN-13(EAN): 9780412140600 Издательство: Springer Рейтинг: Цена: 81050.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Bart De Strooper Название: Macro Roles for MicroRNAs in the Life and Death of Neurons ISBN: 364226204X ISBN-13(EAN): 9783642262043 Издательство: Springer Рейтинг: Цена: 130590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The discovery of microRNAs has revealed an additional level of fine tuning of the genome and how genes are used again and again in different combinations to generate the complexity that underlies for instance the brain. This book examines this field.
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