The Neurons of the First Optic Ganglion of the Bee (Apis mellifera), W.A. Ribi
Автор: Fain Gordon L. Название: Molecular and Cellular Physiology of Neurons, Second Edition ISBN: 0674599217 ISBN-13(EAN): 9780674599215 Издательство: Wiley Рейтинг: Цена: 87590.00 T Наличие на складе: Поставка под заказ. Описание: Gordon Fain`s Molecular and Cellular Physiology of Neurons, Second Edition is intended for anyone who seeks to understand nerve cell function: undergraduate and graduate students in neuroscience, students of bioengineering and cognitive science, and practicing neuroscientists who want to deepen their knowledge of recent discoveries.
Автор: D`Andrea Michael R. Название: Bursting Neurons and Fading Memories ISBN: 0128019794 ISBN-13(EAN): 9780128019795 Издательство: Elsevier Science Рейтинг: Цена: 53890.00 T Наличие на складе: Невозможна поставка. Описание:
Advances in Alzheimer's disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field's best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development.
The clear, compelling, and unifying "Inside-Out" hypothesis of AD is brought to life through a string of scientific publications, synthesizing many known features of disease pathology
A high-level text on AD pathology, and suggestions for progress in a stagnating field
Point-by-point discussion on the issues surrounding the current amyloid cascade, and possible reasons why current clinical trials have failed
Contains high-quality photomicrographs in support of the "Inside-Out" hypothesis using single, double, and triple immunohistochemistry on human AD CNS tissues
Chapters address the need for a unifying plaque nomenclature, the importance of intracellular amyloid, the blood-brain barrier, inflammation, and autoimmunity
Автор: Jeroen Pasterkamp; Marten P. Smidt; J. Peter H. Bu Название: Development and Engineering of Dopamine Neurons ISBN: 1441903216 ISBN-13(EAN): 9781441903211 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections.
Автор: Jeroen Pasterkamp; Marten P. Smidt; J. Peter H. Bu Название: Development and Engineering of Dopamine Neurons ISBN: 1489981802 ISBN-13(EAN): 9781489981806 Издательство: Springer Рейтинг: Цена: 130590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The research directed towards unraveling the molecular programming of mdDA neurons continues to be highly exciting. This book provides an overview of the different stages that are distinguished during mdDA neuronal development.
Автор: Bart De Strooper Название: Macro Roles for MicroRNAs in the Life and Death of Neurons ISBN: 364226204X ISBN-13(EAN): 9783642262043 Издательство: Springer Рейтинг: Цена: 130590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The discovery of microRNAs has revealed an additional level of fine tuning of the genome and how genes are used again and again in different combinations to generate the complexity that underlies for instance the brain. This book examines this field.
Автор: Bart De Strooper Название: Macro Roles for MicroRNAs in the Life and Death of Neurons ISBN: 364204297X ISBN-13(EAN): 9783642042973 Издательство: Springer Рейтинг: Цена: 156720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The discovery of microRNAs has revealed an additional level of fine tuning of the genome and how genes are used again and again in different combinations to generate the complexity that underlies for instance the brain. This book examines this field.
Автор: Hickok Gregory Название: The Myth of Mirror Neurons: The Real Neuroscience of Communication and Cognition ISBN: 0393089614 ISBN-13(EAN): 9780393089615 Издательство: Wiley Рейтинг: Цена: 39600.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: An essential reconsideration of one of the most far-reaching theories in modern neuroscience and psychology.
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