Автор: D`Andrea Michael R. Название: Bursting Neurons and Fading Memories ISBN: 0128019794 ISBN-13(EAN): 9780128019795 Издательство: Elsevier Science Рейтинг: Цена: 53890.00 T Наличие на складе: Невозможна поставка. Описание:
Advances in Alzheimer's disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field's best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development.
The clear, compelling, and unifying "Inside-Out" hypothesis of AD is brought to life through a string of scientific publications, synthesizing many known features of disease pathology
A high-level text on AD pathology, and suggestions for progress in a stagnating field
Point-by-point discussion on the issues surrounding the current amyloid cascade, and possible reasons why current clinical trials have failed
Contains high-quality photomicrographs in support of the "Inside-Out" hypothesis using single, double, and triple immunohistochemistry on human AD CNS tissues
Chapters address the need for a unifying plaque nomenclature, the importance of intracellular amyloid, the blood-brain barrier, inflammation, and autoimmunity
Автор: Fain Gordon L. Название: Molecular and Cellular Physiology of Neurons, Second Edition ISBN: 0674599217 ISBN-13(EAN): 9780674599215 Издательство: Wiley Рейтинг: Цена: 87590.00 T Наличие на складе: Поставка под заказ. Описание: Gordon Fain`s Molecular and Cellular Physiology of Neurons, Second Edition is intended for anyone who seeks to understand nerve cell function: undergraduate and graduate students in neuroscience, students of bioengineering and cognitive science, and practicing neuroscientists who want to deepen their knowledge of recent discoveries.
Название: Physiology of Neurons ISBN: 0367263750 ISBN-13(EAN): 9780367263751 Издательство: Taylor&Francis Рейтинг: Цена: 265410.00 T Наличие на складе: Нет в наличии. Описание: This book systematically explores the details of neuronal physiology, covering membrane biophysics, receptor physiology, sensory transduction and synaptic transmission with its selective pharmacology. Undergraduates will be fully equipped to understand the functions and possibilities of the key units of the brain`s parallel computations.
Автор: Hickok Gregory Название: The Myth of Mirror Neurons: The Real Neuroscience of Communication and Cognition ISBN: 0393089614 ISBN-13(EAN): 9780393089615 Издательство: Wiley Рейтинг: Цена: 39600.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: An essential reconsideration of one of the most far-reaching theories in modern neuroscience and psychology.
Автор: Bart De Strooper Название: Macro Roles for MicroRNAs in the Life and Death of Neurons ISBN: 364226204X ISBN-13(EAN): 9783642262043 Издательство: Springer Рейтинг: Цена: 130590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The discovery of microRNAs has revealed an additional level of fine tuning of the genome and how genes are used again and again in different combinations to generate the complexity that underlies for instance the brain. This book examines this field.
Автор: Graham Hoyle Название: Identified Neurons and Behavior of Arthropods ISBN: 146846969X ISBN-13(EAN): 9781468469691 Издательство: Springer Рейтинг: Цена: 113190.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Identified Neurons and Behavior of Arthropods presents for the larger audience the papers delivered at a symposium of the same title. But in this subject, the role of identified nerve cells in determining behavior, Wiersma stood virtually alone for 30 years.
Автор: Bart De Strooper Название: Macro Roles for MicroRNAs in the Life and Death of Neurons ISBN: 364204297X ISBN-13(EAN): 9783642042973 Издательство: Springer Рейтинг: Цена: 156720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The discovery of microRNAs has revealed an additional level of fine tuning of the genome and how genes are used again and again in different combinations to generate the complexity that underlies for instance the brain. This book examines this field.
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