High Content Screening, D. Lansing Taylor

Автор: Duarte Miguel F. Prazeres; Sofia Aires M. Martins
Название: G Protein-Coupled Receptor Screening Assays
ISBN: 1493923358 ISBN-13(EAN): 9781493923359
Издательство: Springer
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Цена: 130430.00 T
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Описание: This volume explores the considerable efforts that have been directed towards the development of G Protein-Coupled Receptors (GPCR) screening assays in order to disclose GPCR acting compounds, elucidate signaling mechanisms or evaluate compound`s efficacy.

Автор: Paul A. Johnston; Oscar Joseph Trask
Название: High Content Screening
ISBN: 149397355X ISBN-13(EAN): 9781493973552
Издательство: Springer
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Цена: 130430.00 T
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Описание: This second edition details some of the recent trends in HCS/HCA/HCI.  New and updated chapters guide readers through methods that utilize reagents and kits that have been developed to measure cells and subpopulation classifications, control measures, overviews of the data handling issues associated with HCS/HCA/HCI, and methods to implement more complex phenotypic models.  Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, High Content Screening and Analysis-The Ideal Format for Phenotypic Screening: A Powerful Approach to Systems Cell Biology and Drug Discovery, Second Edition aims to ensure successful results in the further study of this vital field.

Автор: G.M. Addison; R. Angus Harkness; D.M Isherwood; R.
Название: Practical Developments in Inherited Metabolic Disease: DNA Analysis, Phenylketonuria and Screening for Congenital Adrenal Hyperplasia
ISBN: 9401083320 ISBN-13(EAN): 9789401083324
Издательство: Springer
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Цена: 81050.00 T
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Описание: The five case studies from Belize, Mauritania, Samoa, Philippines and Japan were prepared as part of a set of 16 studies gathering national experiences from around the world. The studies are intended to ground the FAO `Technical Guidelines on Marine Protected Areas (MPAs)` and `Fisheries` in practical experience and to inform the use of MPAs globally.

Автор: Philip E. Vercoe; Harinder P.S. Makkar; Anthony C.
Название: In vitro screening of plant resources for extra-nutritional attributes in ruminants: nuclear and related methodologies
ISBN: 9400791852 ISBN-13(EAN): 9789400791855
Издательство: Springer
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Цена: 158380.00 T
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Описание: The aim of this manual is to provide a comprehensive guide to the methods involved in collecting, preparing and screening plants for bioactive properties for manipulating key ruminal fermentation pathways and against gastrointestinal pathogens. The manual will better equip the reader with methodological approaches to initiate screening programmes to test for bioactivity in native plants and find ‘natural’ alternatives to chemicals for manipulating ruminal fermentation and gut health. The manual provides isotopic and non-isotopic techniques to efficiently screen plants or plant parts for a range of potential bioactives for livestock production. Each chapter has been contributed by experts in the field and methods have been presented in a format that is easily reproducible in the laboratory. It is hoped that this manual will be of great value to students, researchers and those involved in developing efficient and environmentally friendly livestock production systems.

Автор: E Scott Sills
Название: Screening the Single Euploid Embryo
ISBN: 3319357670 ISBN-13(EAN): 9783319357676
Издательство: Springer
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Цена: 139750.00 T
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Описание: Intended for readers with a background in fertility medicine as well as those less familiar with IVF, this comprehensive work presents an update on preimplantation genetic testing to enable single embryo transfer (SET).

Автор: Hicham Zegzouti; Said A. Goueli
Название: Kinase Screening and Profiling
ISBN: 1493949233 ISBN-13(EAN): 9781493949236
Издательство: Springer
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Цена: 88500.00 T
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Описание:

1. HTRF Kinase Assay Development and Methods in Inhibitor Characterization
Yong Jia, Mari Manuia, and Jose Juarez

2. Application of Eukaryotic Elongation Factor-2 Kinase (eEF-2K) for Cancer Therapy: Expression, Purification, and High-Throughput Inhibitor Screening
Clint D. J. Tavares, Ashwini K. Devkota, Kevin N. Dalby, and Eun Jeong Cho

3. Recombinant Kinase Production and Fragment Screening by NMR Spectroscopy
Byeonggu Han and Hee-Chul Ahn

4. Bioluminescence Methods for Assaying Kinases in Quantitative High-Throughput Screening (qHTS) Format Applied to Yes1 Tyrosine Kinase, Glucokinase and PI5P4Kα Lipid Kinase
Mindy I. Davis, Douglas S. Auld, and James Inglese

5. Using Bioluminescent Kinase Profiling Strips to Identify Kinase Inhibitor Selectivity and Promiscuity
Hicham Zegzouti, Jacquelyn Hennek, and Said A. Goueli

6. Measuring Activity of Phosphoinositide Lipid Kinases Using a Bioluminescent ADP-Detecting Assay
Andrew W. Tai and Jolanta Vidugiriene

7. A High-Throughput Radiometric Kinase Assay
Krisna C. Duong-Ly and Jeffrey R. Peterson

8. A High Content Assay to Screen for Modulators of EGFR Function
Christophe Antczak and Hakim Djaballah
9. Monitoring Protein Kinase Expression and Phosphorylation in Cell Lysates with Antibody Microarrays
Hong Zhang, Xiaoqing Shi, and Steven Pelech

10. From Enzyme to Whole Blood: Sequential Screening Procedure for Identification and Evaluation of p38 MAPK Inhibitors
Silke M. Bauer, Jakub M. Kubiak, Ulrich Rothbauer, and Stefan Laufer

11. Genetically Encoded Fluorescent Indicators to Visualize Protein Phosphorylation in Living Cells
Moritoshi Sato and Yoshio Umezawa

12. Characterization of an Engineered Src Kinase to Study Src Signaling and Biology
Leanna R. Gentry, Andrei V. Karginov, Klaus M. Hahn, and Channing J. Der

13. Screening One-Bead-One-Compound Peptide Libraries for Optimal Kinase Substrates
Thi B. Trinh and Dehua Pei

14. Determination of the Substrate Specificity of Protein Kinases with Peptide Micro- and Macroarrays
Shenshen Lai, Dirk F.H. Winkler, Hong Zhang, and Steven Pelech

15. Rapid Identification of Protein Kinase Phosphorylation Site Motifs Using Combinatorial Peptide Libraries
Chad J. Miller and Benjamin E. Turk

Автор: Taro Noguchi
Название: Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products
ISBN: 9811066221 ISBN-13(EAN): 9789811066221
Издательство: Springer
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Цена: 102480.00 T
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Описание: This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products. It demonstrates how, by using mirror-image proteins for the screening of available natural products, unavailable mirror-image isomers of natural products can be screened in a mirror process.

Автор: R.C. Bird; Bruce F. Smith
Название: Genetic Library Construction and Screening
ISBN: 364247733X ISBN-13(EAN): 9783642477331
Издательство: Springer
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Цена: 46570.00 T
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Описание: These include cDNA cloning and transcript mapping, mutagenesis as well as the cloning of very long transcripts and protocols using limiting amounts of total RNA. Further chapters describe approaches to subtractive cloning technologies as well as novel specialized expression cloning and library screening strategies.