Protein Misfolding and Cellular Stress in Disease and Aging, Peter Bross; Niels Gregersen
Автор: Judit Ov?di; Ferenc Orosz Название: Protein folding and misfolding: neurodegenerative diseases ISBN: 9048181275 ISBN-13(EAN): 9789048181278 Издательство: Springer Рейтинг: Цена: 156720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Offering all the latest in the study of neurodegenerative diseases, this book reviews the molecular events initiated by unfolded or misfolded proteins leading to conformational human diseases, especially those found in Parkinson`s and Alzheimer`s diseases.
Автор: Martin Beckerman Название: Fundamentals of Neurodegeneration and Protein Misfolding Disorders ISBN: 3319342843 ISBN-13(EAN): 9783319342849 Издательство: Springer Рейтинг: Цена: 104480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer`s disease and Parkinson`s disease to Huntington`s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Автор: Beckerman, Martin Название: Fundamentals of neurodegeneration and protein misfolding disorders ISBN: 3319221167 ISBN-13(EAN): 9783319221168 Издательство: Springer Рейтинг: Цена: 111790.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer’s disease and Parkinson’s disease to Huntington’s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today’s forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.
Автор: Andrew F. Hill; Kevin J. Barnham; Stephen P. Botto Название: Protein Folding, Misfolding, and Disease ISBN: 1493956892 ISBN-13(EAN): 9781493956890 Издательство: Springer Рейтинг: Цена: 83850.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Protein misfolding is a key feature of many disorders in humans, given that over twenty proteins are known to misfold and cause disease. In Protein Folding, Misfolding, and Disease: Methods and Protocols, experts in the field present a collection of current methods for studying the analysis of protein folding and misfolding, featuring strategies for expressing and refolding recombinant proteins which can then be utilized in subsequent experiments. This detailed volume also covers methods for analyzing the formation of amyloid, protocols for determining the size and structure of native and misfolded proteins, as well as specific examples of where misfolded proteins can be examined using state-of –the-art technologies. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Up to date and authoritative, Protein Folding, Misfolding, and Disease: Methods and Protocols offers researchers the tools necessary to move ahead in this vital field.
Автор: Peter Bross; Niels Gregersen Название: Protein Misfolding and Disease ISBN: 161737332X ISBN-13(EAN): 9781617373329 Издательство: Springer Рейтинг: Цена: 135090.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In addition, deficiencies of proteins that are engaged in assisting and supervising protein folding (protein quality control) may impair the folding of many other proteins, resulting in pathological phenotypes.
Автор: Heinz Fabian; Dieter Naumann Название: Protein Folding and Misfolding ISBN: 3642270573 ISBN-13(EAN): 9783642270574 Издательство: Springer Рейтинг: Цена: 104480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book explores biophysical methods for probing conformational changes with high kinetic and structural resolution, and the strengths and limitations of infrared spectroscopy for examining folding events over time scales ranging from picoseconds to minutes.
This book reviews current research on the important processes involved in neurodegenerative diseases (e.g. Alzheimer's disease) and the peptides and proteins involved in the amyloidogenic processes. It covers the design and developments of anti-amyloid inhibitors, and gives readers a fundamental understanding of the underlying oligomerization and aggregation processes of these diseases from both computational and experimental points of view.
Автор: Sandal, Massimo Название: Early Stage Protein Misfolding and Amyloid Aggregation ISBN: 012812251X ISBN-13(EAN): 9780128122518 Издательство: Elsevier Science Рейтинг: Цена: 196510.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Early Stage Protein Misfolding and Amyloid Aggregation, Volume 329, the latest in the International Review of Cell and Molecular Biology series presents comprehensive reviews and current advances in cell and molecular biology, including articles that address the structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth.
The series has a worldwide readership and maintains a high standard by publishing invited articles on important and timely topics as authored by prominent cell and molecular biologists.
Автор: Olga Gursky Название: Lipids in Protein Misfolding ISBN: 331917343X ISBN-13(EAN): 9783319173436 Издательство: Springer Рейтинг: Цена: 148020.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Protein misfolding can also involve errors in the topology of the folded proteins and their assembly in lipid membranes.
Автор: Uversky Vladimir N., Fink Anthony L. Название: Protein Misfolding, Aggregation and Conformational Diseases / Part A: Protein Aggregation and Conformational Diseases ISBN: 038725918X ISBN-13(EAN): 9780387259185 Издательство: Springer Рейтинг: Цена: 200260.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume fills the gap in protein review and protocal literature while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. It is devoted to the general questions of conformational disorders and includes discussion of involvement of such common factors as molecular chaperones, oxidative damage, proteasome, glycosoaminoglycans, serum amyloid protein P and several others in the development of different disorders. Some experimental techniques applicable for the visualization of protein deposition in vivo and in vitro are also present.
Автор: Uversky Vladimir N., Fink Anthony Название: Protein Misfolding, Aggregation and Conformational Diseases / Part B: Molecular Mechanisms of Conformational Diseases ISBN: 038736529X ISBN-13(EAN): 9780387365299 Издательство: Springer Рейтинг: Цена: 243800.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The second volume continues to fill the gap in protein review and protocal literature while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorders.
Автор: Vladimir N. Uversky; Anthony Fink Название: Protein Misfolding, Aggregation and Conformational Diseases ISBN: 1441938516 ISBN-13(EAN): 9781441938510 Издательство: Springer Рейтинг: Цена: 191550.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Research indicates that most neurodegenerative diseases, systemic amyloidoses and many others, arise from the misfolding and aggregation of an underlying protein. The authors summarize recent progress in the understanding of the relationships between protein misfolding, aggregation and development of protein deposition disorders.
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