Synaptic Plasticity, Michael R. Kreutz; Carlo Sala
Автор: Dennis J. Selkoe; Antoine Triller Название: Synaptic Plasticity and the Mechanism of Alzheimer`s Disease ISBN: 3642095194 ISBN-13(EAN): 9783642095191 Издательство: Springer Рейтинг: Цена: 213360.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: A biochemical hypothesis - that Alzheimer`s disease (AD) is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies.
Автор: Chalupa Leo M Название: Cerebral Plasticity ISBN: 0262015234 ISBN-13(EAN): 9780262015233 Издательство: Wiley Рейтинг: Цена: 8440.00 T Наличие на складе: Невозможна поставка. Описание:
A survey of the latest research, covering such topics as plasticity in the adult brain and the underlying mechanisms of plasticity.
The notion that neurons in the living brain can change in response to experience -- a phenomenon known as "plasticity" -- has become a major conceptual issue in neuroscience research as well as a practical focus for the fields of neural rehabilitation and neurodegenerative disease. Early work dealt with the plasticity of the developing brain and demonstrated the critical role played by sensory experience in normal development. Two broader themes have emerged in recent studies: the plasticity of the adult brain (one of the most rapidly developing areas of current research) and the search for the underlying mechanisms of plasticity -- explanations for the cellular, molecular, and epigenetic factors controlling plasticity. Many scientists believe that achieving a fundamental understanding of what underlies neuronal plasticity could help us treat neurological disorders and even improve the learning capabilities of the human brain.
This volume offers contributions from leaders in the field that cover all three approaches to the study of cerebral plasticity. Chapters treat normal development and the influences of environmental manipulations; cerebral plasticity in adulthood; and underlying mechanisms of plasticity. Other chapters deal with plastic changes in neurological conditions and with the enhancement of plasticity as a strategy for brain repair.
Автор: Trussell Название: Synaptic Mechanisms in the Auditory System ISBN: 1461429587 ISBN-13(EAN): 9781461429586 Издательство: Springer Рейтинг: Цена: 121890.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Here is a basic reference for students, clinicians and researchers on how synapses in the auditory system function to encode acoustic signals. The volume brings together classical cell physiology, modern tools for analysis and the problems of auditory coding.
Автор: Jacques Fantini Название: Brain Lipids in Synaptic Function and Neurological Disease ISBN: 0128001119 ISBN-13(EAN): 9780128001110 Издательство: Elsevier Science Рейтинг: Цена: 104410.00 T Наличие на складе: Невозможна поставка. Описание:
Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer's, Creutzfeldt-Jakob's and Parkinson's. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders.
Written to provide a "hands-on" approach for readers
Biochemical structures explained with molecular models, and molecular mechanisms explained with simple drawings
Step-by-step guide to memorize and draw lipid structures
Each chapter features a content summary, up-to-date references for additional study, and a key experiment with an explanation of the technique
Автор: Sala, Carlo Название: Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and ISBN: 0128001097 ISBN-13(EAN): 9780128001097 Издательство: Elsevier Science Рейтинг: Цена: 104410.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings.
In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders.
Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field.
The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms.
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